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Granulocyte colony-stimulating factor (G-CSF; AX200; Filgrastim) is a stroke drug candidate with excellent preclinical evidence for efficacy. A previous phase IIa dose-escalation study suggested potential efficacy in humans. The present large phase IIb trial was powered to detect clinical efficacy in acute ischemic stroke patients.
This paper presents a new strategy to combine the power of antibody based capturing of target species in complex samples with the benefits of microfluidic reverse phase sample preparation on an integrated sample enrichment target (RP-ISET) and the analysis speed of MALDI MS. The immunoaffinity step is performed on an in-house developed 3D-structured high surface area porous silicon (PSi) matrix, w
Socioeconomic status could potentially impact on which type of rheumatic diagnosis a patient receives. We determined whether different socioeconomic status is a risk factor for being diagnosed with spondyloarthritis (SpA) or chronic pain. In a nested case-control study, we identified two sets of adult cases diagnosed with (i) SpA (n = 1,194) and (ii) chronic pain (n = 3,730) during 2010-2012 in Sk
Purpose: To evaluate waiting times for first-eye cataract surgery in Sweden following widespread adoption of the Nationell Indikationsmodell for Kataraktextraktion (NIKE) tool for prioritizing patients for cataract surgery. Methods: Waiting times for all first-eye cataract surgeries in Sweden in 2009-2011 were identified from the Swedish National Cataract Register. Waiting times were compared acco
Strain-stress relationships for physical properties are of interest for heteroepitaxial material systems, where strain and stress are inherent due to thermal expansion and lattice mismatch. We report linear perturbation theory strain and stress relationships for optical phonon modes in monoclinic crystals for strain and stress situations which maintain the monoclinic symmetry of the crystal. By us
Li-rich nickel cobalt manganese oxides (LNCM) cathode with full gradient compounds is prepared by using an ethanol assisted co-precipitation method. The rationally designed procedure involves gradient distributions of transition-metal ions, in which the Ni content increases continuously, Mn content decreases gradually and Co keeps at a low level. The employing ethanol during the synthesis adjusts
Large amounts of dendrochronological data sets exported from the SEAD databasehave in this study been used to analyze timber trade and provenance from thethree Scandinavian towns of Copenhagen, Stockholm and Nya Lödöse/Gothenburgduring the medieval and early modern era. In total, 964 dendrochronologicalsamples with a dating and provenance description were compiled in this studyand compared with wrLarge amounts of dendrochronological data sets exported from the SEAD database have in this study been used to analyze timber trade and provenance from the three Scandinavian towns of Copenhagen, Stockholm and Nya Lödöse/Gothenburg during the medieval and early modern era. In total, 964 dendrochronological samples with a dating and provenance description were compiled in this study and compared wi
Jorunn Joiner and Mari Komnæs also employ digital tools, albeit other ones, to shed light on the interaction between narratives of exceptionalism, travel, and place. In ‘Mapping Nordic Exceptionalism with GIS: The Odin Migration Theory and the Search for a Northern Heritage’, they use digital mapping tools to visualise the journeys of two travellers from different centuries in their search for a N
Modeling of real-world fuels and fuel mixtures in combustion engines, using computational fluid dynamics (CFD), calls for the development of compact and computationally efficient chemical kinetic mechanisms. To improve the modeling capabilities of multicomponent fuels it is necessary to transition from the single-component descriptions of fuels and move toward more complex, accurate multicomponent
SGEM13 Schedule D e p a r t m e n t o f H u m a n G e o g r a p h y H u m a n E c o l o g y D i v i s i o n SGEM25 Fieldmethods & GIS DRAFT (19.03.2018) – Schedule (25.04.2018-03.06.2018) Week Date Time Topic Lecturer Room 17 Thur 25/4 10-12 Introduction ALH/MB/VR Världen Fri Indiv. Group Meetings 18 Mon 30/4 10-15 Seminar 1 Groups 1-6 ALH/MB Rio Wed 2/5 10-13 Groups 7-12 Lecture: Methodologies I
https://www.keg.lu.se/sites/keg.lu.se/files/sgem25_schedule_2018_draft_19-03-2018.pdf - 2026-07-13
An inclusive search for anomalous production of two prompt, isolated leptons with the same electric charge is presented. The search is performed in a data sample corresponding to 4.7 fb(-1) of integrated luminosity collected in 2011 at root s = 7TeV with the ATLAS detector at the LHC. Pairs of leptons (e(+/-)e(+/-), e(+/-)mu(+/-), and mu(+/-)mu(+/-)) with large transverse momentum are selected, an
We report a search for first generation scalar leptoquarks using 1.03 fb(-1) of proton-proton collisions data produced by the Large Hadron Collider at root s = 7 TeV and recorded by the ATLAS experiment. Leptoquarks are sought via their decay into an electron or neutrino and a quark, producing events with two oppositely charged electrons and at least two jets, or events with an electron, missing t
Aim: This thesis serves two purposes. First, it informs specialists in global public health to consider a broader spectrum of pediatric disease. Second, it informs specialists in pediatric hospital care of how the feasibility of their clinical practice depends on a functioning health care system. Methods: The papers contextualize pediatric disease entities that so far have received relatively sp
Spatial Data Infrastructures (SDIs) have been identified essential for environmental management and development activities around the world. Meanwhile, development of frameworks to monitor and evaluate SDIs is currently an important research area. This study proposes Balanced Scorecard (BSC) as a framework for evaluation and monitoring the implementation of SDIs. The concept and advantages of BSC
Popular Abstract in Swedish Stroke, eller slaganfall, är en sammanfattande benämning på sjukdomar som drabbar blodförsörjningen i hjärnan. Varje år insjuknar cirka 30000 personer i Sverige i stroke, av dessa drabbas cirka 15% av blödningar medan resterande 85% får infarkter, dvs blodpropp i hjärnan. Stroke upptar fler vårddagar i slutenvården än någon annan somatisk sjukdom. Medianåldern för insjuBackground Stroke is a serious vascular disorder that comprises intracerebral hemorrhages, subarachnoid hemorrhages and ischemic stroke (IS). The etiology of stroke, including hereditary components induced by cellular mechanisms, is therefore a research field of vital importance. The aim of this thesis was to assess possible genetic impact on stroke risk. We thus evaluated family history of strok
In cerebral palsy (CP) there is an increased risk of scoliosis. It is important to identify a progressive scoliosis early-on because the results of surgery depend on the magnitude of the curve. The Swedish follow-up program for cerebral palsy (CPUP) includes clinical examinations of the spine. The reliability and validity of the assessment method have not been studied. In this study we evaluate th
A well-founded decision needs to take into account as much information from a sample as possible. In gamma spectrometry, the number of photons and their energy are the two quantities readily accessible to the physicist and both should be used in order to increase the power of a statistical test. While the problem of counts of pulses has been much studied the problem of spectral distribution of pul
Recent experiments on flapping flight in animals have shown that a variety of unrelated species shed a wake behind left and right wings consisting of both tip and root vortices. Here we present an investigation using Particle Image Velocimetry (PIV) of the behaviour and interaction of trailing vortices shed by paired, fixed wings that simplify and mimic the wake of a flying animal with a non-lifti
