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Background: Women who deliver pre-term have been reported to have increased future risks of cardiometabolic disorders. However, their long-term risks of ischemic heart disease (IHD) and whether such risks are due to shared familial factors are unclear. A better understanding of these risks may help improve long-term clinical follow-up and interventions to prevent IHD in women. Objectives: The purp

In this paper, the execution and results of an evacuation experiment that was conducted in a road tunnel in Stockholm in 2014 is presented. The primary objective of the experiment was to evaluate the effectiveness of different emergency exit portal designs, and other technical installations/aids in the tunnel, during a fire evacuation in smoke. Based on the results, it is concluded that the emerge

Increased incidence of narcolepsy type 1 (NT1) was observed following Pandemrix®‐vaccination, initiated as a preventive measure against the 2009 Influenza pandemic. Here, single cell analysis was conducted to suggest a lower number of CD8+CD27+ T cells among these patients. These findings provide understanding into the autoimmune pathogenesis of NT1.

Background: More women in reproductive ages are entering occupations where exposure to whole body vibrations (WBV) is common (e.g. in transportation and construction). Previous studies based on self-assessed exposure suggest increased risks of adverse birth outcomes, but it is unclear at what exposure levels and if the current exposure guidelines are appropriate during pregnancy. Objectives: To in

Clinical trial results have recently demonstrated that inhibiting inflammation by targeting the interleukin-1β pathway can offer a significant reduction in lung cancer incidence and mortality, highlighting a pressing and unmet need to understand the benefits of inflammation-focused lung cancer therapies at the genetic level. While numerous genome-wide association studies (GWAS) have explored the g

Non-ownership models, where firms rather than consumers remain product owners, are advocated as a way for firms to prolong product lifetimes and contribute to a more Circular Economy. However, it has been suggested that such models could actually encourage ‘faster cycling’, meaning earlier product replacement and shorter product lifetimes. Within recent policy discussions, product durability to pr

To update the European League Against Rheumatism (EULAR) recommendations for vaccination in adult patients with autoimmune inflammatory rheumatic diseases (AIIRD) published in 2011. Four systematic literature reviews were performed regarding the incidence/prevalence of vaccine-preventable infections among patients with AIIRD; efficacy, immunogenicity and safety of vaccines; effect of anti-rheumati

Strengthening of masonry walls is a means to improve the energy performance of modern external masonry walls without further increasing their total thickness. The present paper evaluates the feasibility - here refer-ring to ease-of-application and structural performance - of several techniques aimed at strengthening mason-ry walls subjected to eccentric axial loading. Four full scale walls made of

During the last years, numerous research projects focussed on re-examination of past excavations, giving birth to re-evaluation of their documentation and material or to new discoveries. The aim of this paper is to present an ongoing research on the digital re-assessment of the Ayia Irini sanctuary’s stratigraphy using 3D GIS, by corroborating published material with data extracted from the origin

Quantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six cancer types based on a total of 296,215 cases and 301,319 controls of European ancestry, here we estimate the pair-wise genetic correlations between breast, colorectal, head/neck, lung, ovary and prostate

Civil society is often understood as a normative vehicle for the promotion of human rights and democracy, as it plays a central role in ensuring gender equality and advocating for local ownership in the decision-making processes of states. Civil society agents and organizations have been instrumental in promoting and advancing the Women, Peace, and Security (WPS) agenda. In this chapter, we examin

Insect genitalia are important for species identification and taxonomy and are key traits for the evolution of reproductive isolation through their 'lock-And-key mechanism'. Nevertheless, few studies have evaluated intraspecific variation and the impact of seasonal environmental variation on genital morphology. We used geometric morphometric analysis to quantify male genital morphology within and

We use a carbon-cycle data assimilation system to estimate the terrestrial biospheric CO2 flux until 2090. The terrestrial sink increases rapidly and the increase is stronger in the presence of climate change. Using a linearized model, we calculate the uncertainty in the flux owing to uncertainty in model parameters. The uncertainty is large and is dominated by the impact of soil moisture on heter

This paper presents stability theory of adaptive systems using an extension of the Yakubovich-Kalman-Popov (YKP) lemma. Such stability analysis is relevant for observer-based adaptive feedback control systems. Relaxation of the controllability and observability conditions imposed in the YKP lemma can be made for a class of adaptive systems described by a linear time-invariant (LTI) system with ada

Activity-based financing (ABF) and global budgeting are two common reimbursement models in hospital care that embody different incentives for cost containment and quality. The purpose of this study was to explore and describe perceptions from the provider perspective about how and why replacing variable ABF by global budgets affects daily operations and provided services. The study setting is a la

AIMS/HYPOTHESIS: Finding new treatment alternatives for individuals with diabetes with severe insulin resistance is highly desired. To identify novel mechanisms that improve glucose uptake in skeletal muscle, independently from insulin levels and signalling, we have explored the therapeutic potential of a short peptide sequence, RG54, derived from apolipoprotein A-I (ApoA-I).METHODS: INS-1E rat cl