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We evaluate the shared genetic regulation of mRNA molecules, proteins and metabolites derived from whole blood from 3029 human donors. We find abundant allelic heterogeneity, where multiple variants regulate a particular molecular phenotype, and pleiotropy, where a single variant associates with multiple molecular phenotypes over multiple genomic regions. The highest proportion of share genetic re

The experience of heritage sites through digital technology is an increasingly important topic for researchers and practitioners. Drawing upon telepresence theory, this study explores how a visitor’s destination image is formed and its impact on satisfaction in a virtual heritage site experience. The survey results show that telepresence, cognitive image, affective image, and satisfaction are posi

Both plasma tau phosphorylated at threonine-181 (pTau181) and tau PET show potential for detecting Alzheimer’s disease (AD) pathology and predicting clinical progression. In this study, we performed a head-to-head comparison between plasma pTau181 and tau PET along the AD continuum. Methods: We included participants from the Amsterdam Dementia Cohort who underwent 18F-flortaucipir (tau) PET and ha

BackgroundDiabetes and prediabetes are well-recognized risk factors for cardiovascular disease (CVD) and are marked by vascular endothelial dysfunction (ED). However, there is a scarcity of thorough population-based studies examining ED in individuals with diabetes/prediabetes free from manifest CVD. Here, we examined the association between ED assessed by reactive hyperaemia index (RHI) in the fi

Introduction: Educational attainment, widely used in epidemiologic studies as a surrogate for socioeconomic status, is a predictor of cardiovascular health outcomes. Methods: A two-stage genome-wide meta-analysis of low-density lipoprotein cholesterol (LDL), high-density lipoprotein cholesterol (HDL), and triglyceride (TG) levels was performed while accounting for gene-educational attainment inter

Observational studies have revealed that ischemic heart disease (IHD) has a unique manifestation on electrocardiographic (ECG). However, the genetic relationships between IHD and ECG remain unclear. We took 12-lead ECG as phenotypes to conduct genome-wide association studies (GWAS) for 41,960 samples from UK-Biobank (UKB). By leveraging large-scale GWAS summary of ECG and IHD (downloaded from Finn

The annual epidemics of seasonal influenza is partly attributed to the continued virus evolution. It is challenging to evaluate the effect of influenza virus mutations on evading population immunity. In this study, we introduce a novel statistical and computational approach to measure the dynamic molecular determinants underlying epidemics using effective mutations (EMs), and account for the time

Research centers represent a specific organizational format for linking the traditional university organization with external actors, goals, and processes in time-limited, concentrated efforts of research and collaboration. Yet, the center format contains large variations, and centers act as interfaces between university organizations, societal actors, and research funders in multifaceted ways. In

The impact of preoperative electrophysiology on outcome of surgical treatment in ulnar nerve entrapment at the elbow (UNE) is not clarified. Our aim was to evaluate influence of preoperative electrophysiologic grading on outcome and analyse how age, sex, and in particular diabetes affect such grading. Electrophysiologic protocols for 406 UNE cases, surgically treated at two hand surgery units repo

Studies that consider the position of women in the Australian labour market have consistently demonstrated evidence of unequal outcomes between men and women. A number of structural and behavioural explanations have been advanced for the continued existence of this gender inequality. This article contributes to the supply-side debate with a study of the labour market expectations of women. Questio

Mesenchymal stromal cells (MSCs) and MSC-derived extracellular vesicles (EVs) have emerged as innovative therapeutic agents for the treatment of sepsis and acute respiratory distress syndrome (ARDS). Although their potential remains undisputed in pre-clinical models, this has yet to be translated to the clinic. In this review, we focused on the role of microRNAs contained in MSC-derived EVs, the E

Sex-limited polymorphism is an interesting evolutionary phenomenon, which is widespread across organisms. Studying ultimate mechanisms that result in the evolution of sex-limited polymorphism can provide a window into how natural and/or sexual selection can result in the evolution of complex phenotypes. Here, I use butterflies from the tribe Polyommatini to study the evolutionary mode and tempo of

The emission reductions of the European steel industry which account for 5 of CO2 emissions within the European Union (EU), have thus far been limited in part due to the free allocation under the Emissions Trading System (ETS). Legislation has been introduced, aimed at increasing the effectiveness of the ETS by phasing out the free allocation while simultaneously protecting the European steel indu

This study explores the engagement of bisexual individuals with the Netflix series Heartstopper in the context of media representations of bisexuality. It delves into the intersections of media engagement, representation, and identity through a social constructionist lens. This thesis lends its voice to twelve individuals who experience attraction to multiple genders and identify as bisexual, pans

The main goal of this study is to provide insights and knowledge into the matters of queer representation in entertainment media, with a particular focus on the depiction of queerness in association with crime on-screen, from the perspective of the LGBTQIA+ community itself. More specifically, the investigation is grounded on four main theories relating to queer studies, intersectionality, social

The severe decline in olive oil production recorded in the last years is having an economic impact on many Mediterranean countries. The aim of this MSc thesis is to predict the olive yield by means of satellite vegetation indices and meteorological data mostly retrieved by satellite remote sensors. Estimating olive yield production using remote sensing data is reasonably new as few scientific pape

In Oslo, small-scale private landlords dominate the private rental sector (PRS). The characteristic ownership structure has given way to intermediary actors, such as letting agents and online platforms, operating between landlords and tenants. The findings of this thesis show that intermediaries in the Oslo PRS do not play the role as neutral middlemen, but on the contrary represent the market int

This master’s thesis examines the challenges and changes faced by voluntary local sections of the German Federal Agency for Technical Relief (THW). The study aims to identify key factors influencing volunteer recruitment, training, and retention within these sections, particularly focusing on the impact of societal changes, workload, training limitations, and administrative burdens on the voluntee