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A computational method is described and tested for prediction of ligand-binding poses between the human farnesoid X receptor and a set of 36 potential agonists, provided by the D3R Grand Challenge 2016. Using tools such as Molecular Docking, Molecular Dynamics, Reconnaissance metadynamics and cluster analysis, the method is an attempt to predict the binding pose without being biased by experimenta
With population that exceeds 90 million inhabitants, Egypt is one of the large Arab developing countries where the government policies headed towards constructing new urban communities to absorb the vast increase in population. Although the physical planning of the new urban settlements took into consideration the existence of outdoor recreational services and facilities, the quality and adequacy
Both within the EU and within other regions/countries, there is a need to measure and monitor the well-being/Quality of Life (QoL) of people, in order to identify, anticipate, and address potential social or economic problems, at national and regional levels. This study presents a model to quantitatively estimate the spatial well-being (QoL) distribution across the EU-28 member states down to the
This study examines the effects of progressive and regressive abortion reforms on women’s educational and labour market outcomes in Mexico. First trimester abortions became legal in Mexico City in 2007. Following the progressive legislative reform, 18 other Mexican states implemented more restrictive legislation on abortions. By using quarterly survey data and a difference-in-differences approach,
This thesis investigates if the recent decisions by the Commission on State aid in direct tax law are intruding on the EU Member States’ fiscal sovereignty. The author concludes that the Commission’s basic legal arguments of the reference system, being the corporate income tax system of the relevant Member States, as well as the arm’s length principle as a tool to assess selectivity in article 107
This thesis is about queer youth in total institutions, and the meaning those institutions might have on the identity formation process. The thesis itself consists of two smaller sub-studies, a literature review of some of the existing research on queer youth in total institutions, and a discourse analysis of the identity aspect using texts written by queer youth who has spent time in a total inst
Asthma exacerbation is among the leading causes of mortality and morbidity. Bronchial epithelial cells (BECs) are of interest because they represent not only a physical barrier against infections, but also a biological barrier between the inhaled agents, such as allergens, and the immune system. As known, systemic inflammation of the lungs, or dietary factors could have effects on lung disease wor
The purpose of this thesis was to investigate how extracellular vesicles extracted from cows milk interacts with the surfaces hydrophilic surface, DOPC bilayer surface, 95% DOPC and 5% DOTAP mixture bilayer surface and 1:1 ratio of DOPC and DOTAP mixture bilayer surface, and colloidally characterize EVs by determining the hydrodynamic radius and zeta potential. To determine the size and zeta poten
Inför en digitaliserad, global ekonomi, vari nära hälften av multinationella företagsvinster går obeskattade, står vi på randen till en ny ordning för gränsöverskridande företagsbeskattning. Med sin tvåpelarlösning söker OECD lägga de första byggstenarna. En internationell minimiskatt, att krävas ut från stora multinationella gruppers slutliga föräldrar, föreslås att mota baseroderande skatteplaneFacing a digitalized global economy, where almost half of multinational corporate profits go untaxed, we find ourselves on the verge of tax revolution. With its two-pillar solution, the OECD seeks to lay the first building blocks of a new system for cross-border corporate income taxation. To counter avoidance, states are presented with an international top up minimum tax, to be charged at multinat
The search for doubly charged Higgs bosons (H±±) aims at resolving the mass generation mechanism of neutrinos in the Standard Model. The current search by the ATLAS Same-Sign Dilepton group uses the decay product of H±± to a pair of same-sign hadronic τ-leptons, which is an extension of their previous search using same-sign dielectrons and dimuons. This thesis focuses on the study of one of the ba
All words in Swedish have a particular melody. There are two tonal patterns that are observed in different prosodic and morphological contexts – accent 1 and accent 2. The tone of accent 1 is the default melody in Swedish and is said to be of intonational nature. The melody of accent 2, on the other hand, only occurs in presence of certain suffixes in the word, hence, accent 2 is claimed to be a p
This thesis draws attention to China’s information management of its Arctic policy, and the way in which China has left out information in official English-language publications that could be deemed sensitive by Western actors. This thesis examines how the news media of Iceland has reported on China’s Arctic policy over two different periods, dating from 2012 - 2013 and 2018 - 2019, in order to me
National identity is used as a representation of what a country wants to transmit as its own impression of ‘self’, and usually it is formed around the concept of an ‘other’. Nonetheless, if two national identities are contradictory; it can hinder the development of desirable bilateral relations, which is the case of Japan and South Korea. Taking the Takeshima/Dokdo territorial dispute as a referen
The purpose of this work was to contribute to the creation of a prototype of a new type of robot called Agile Parallel Kinematic Manipulator or AgilePKM for short. Designing, building and controlling a new type of robot is a task which goes beyond the scope of any master thesis project, but there are subtasks which are more suitable to handle within the available time frame. A principle design wil
This thesis draws on eleven semi-structured interviews with Duterte supporters. It analyses how the president is perceived by Filipinos, more specifically by those who support him and live in Sweden and the Philippines, in order to provide an in-depth understanding of the appeal of Duterte to his supporters. The thesis focuses on the main reasons for Duterte’s popularity, the war against drugs and
This thesis is a study of the Swedish culture politics, in particular the area of cultural heritage. My ambition was to look into the cooperation between the municipalities in Scania (Skånes kommuner) and County Administrative Board in Scania (Länsstyrelsen i Skåne) to try and find out if that is the reason for the absence of useful information about our prehistoric cultural heritage on the web p
Mervärdesskatt och Transfer Pricing är två av de stora områdena inom internationell skatterätt, då det förra är en indirekt skatt och baseras på det subjektiva priset och det senare området tillhör direkt beskattning och använder ett objektivt, fiktivt pris för beräkning kan de vid första anblick sakna anknytning. Det finns dock en risk att justeringar av det pris som använts för Transfer Pricing-Value added tax and Transfer Pricing are two of the major areas of international tax law, as the former one uses a subjective price for the calculation of taxation and the latter one uses an objective price the two regimes seemingly lack interaction. There is however a possibility that an adjustment of the price used for Transfer Pricing purposes might have an effect on the VAT due. VAT is a har
The objective of this qualitative study was to explore how six South African HIV-diagnosed persons experience the social and emotional consequences of being infected and how the support structure provided by the non-governmental organization Keiskamma affect their everyday lives. The qualitative approach consisted of semi-structured interviews with six of Keiskamma’s patients and observations of
This master thesis examines if the policy of school choice, which was implemented in the early 1990s, may trigger segregation of different social groups in independent schools in the city of Malmö. The major actors for school choice are the parents, due to their responsibility to choose schools for their children. For the purpose of my research, the major focus lays on the factors that parents con
