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Popular Abstract in Swedish I hjärnan finns många olika typer av nervceller. De använder sig av olika signalsubstanser, kallade neurotransmittorer, för att kommunicera med andra nervceller. En viss typ av nervceller använder neurotransmittorn dopamin. Dopaminceller finns på många ställen i hjärnan men de flesta ligger i mellanhjärnan i ett par olika cellgrupper som var och en skickar signaler tillParkinsons disease (PD) is a neurodegenerative disorder where dopaminergic neurons of the substantia nigra (SNc) in the mesencephalon are progressively eliminated. The ensuing loss of dopaminergic innervation of the basal ganglia manifests itself as severe motor deficits in PD patients. Clinical trials have shown that cell replacement therapy, where dopaminergic neuroblasts derived from fetal vent

Background and Purpose-To enable self-reporting of functional outcome in quality registers, the corresponding questions have to be easy to interpret. In scientific research, the modified Rankin Scale (mRS) is a standard assessment method. Such methods, with an outsider observer, are not feasible to use in quality registers. For several aspects, eg, comparisons between outcome in clinical studies a

Phononic and magnetic Raman scattering are studied in La2-x-yNdySrxCuO4 with three doping concentrations: x1/8, y = 0; x1/8, y = 0.4; and x = 0.01, y = 0. We observe strong disorder in the tilt pattern of the CuO6 octahedra in both the orthorhombic and tetragonal phases that persist down to 10 K and are coupled to bond disorder in the cation layers around 1/8 doping independent of Nd concentration

The parental questionnaire FTF (Five to Fifteen) was given to parents of 76 children (mean age 11 years) diagnosed with ADHD. About half of the children had at least once been referred to a speech- and language pathologist. Most of them had not received any intervention or follow-up. A factor analysis identified six problem areas, which explain close to 75% of the total variation: Cognitive Skills

Popular Abstract in Swedish Efter den senaste istiden har klimatet varit dynamiskt med både stora och snabba klimatförändringar, om än inte av samma storlek som under istiden. Hur utbredda och vilka effekter dessa klimatförändringar har haft är dock inte helt kartlagt. Målet med denna avhandling är att i detalj rekonstruera de klimat- och miljöförändringar som har påverkat ögruppen Tristan da CunhIt has been shown that the present interglacial has been climatically dynamic with both rapid and severe climatic fluctuations. The spatial and temporal differences of these changes are however not fully resolved. The aim of this thesis is to present a detail high resolution record of past climate changes from the central South Atlantic. Peat and lacustrine sediment sequences were retrieved from

Trisomy 8 as the sole abnormality is the most common karyotypic finding in acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS), occurring in approximately 5% and 10% of the cytogenetically abnormal cases, respectively. However, despite the high frequency of +8, much remains to be elucidated as regards its epidemiology, etiology, clinical impact, association with other chromosomal abno

The Galactic Bulge has long been assumed to be a largely old stellar population. However, some recent studies based on observations with the HST WF/PC-1 and WFPC2 of stars in the Galactic Bulge have concluded that the old population may not make up more then 30% of the total. Other studies using HST/WFPC2 differential studies of `Bulge' globular clusters and field stars have found the bulge to be

Bone mineral density (BMD) measurements are widely used to estimate the risk of osteoporotic fractures. In addition, many other risk factors have been identified, sonic of which are known to add to the risk independently of BMD measurements. The combination of BMD with such risk factors increases the gradient of risk/standard deviation (SD) than that achieved by BMD alone. In this paper, we report

Background. Although myocardial infarction (MI) is strongly related to smoking, few have studied why some smokers are more vulnerable than others. This study explored how the risk of MI in current and former smokers is modified by other cardiovascular risk factors. Methods. Incidence of MI (fatal and nonfatal) amongst 10619 women, 48.3 ± 8.2 years old, were studied in relation to smoking, hyperte

Serine protease inhibitors (Serpins) are involved in the pathogenesis of neurodegenerative dementia, including the two most common types, Alzheimer’s disease (AD) and dementia with Lewy bodies (DLB). The pathological characteristics of AD include senile plaques, mainly composed of aggregated amyloid-beta peptide (Abeta1-42), but also serpins, and neurofibrillary tangles of hyperphosphorylated tau

Here we present the results of a study of the electronic structure using the resonant inelastic scattering process at the F 1s photoabsorption edge in LiF and O 1s edge of MgO crystals. In case of excitations in the sub-threshold region, the Raman-type linear dispersion of X-ray fluorescence peak was observed for the studied compounds. In LiF, the narrowing of the X-ray fluorescence peak is observ

We report on the viscoelastic properties of dough and gluten (prepared by ultracentrifugation) after the flour lipids had been removed by solvents differing in polarity (chloroform, ethanol and diethylether). The extracted lipids were fractionated by thin layer chromatography. The flours differed in lipid composition after the extraction. Ethanol removed more polar lipids than the other solvents.

Sexual dimorphism is widespread in lizards, with the most consistently dimorphic traits being head size (males have larger heads) and trunk length (the distance between the front and hind legs is greater in females). These dimorphisms have generally been interpreted as follows: (1) large heads in males evolve through male-male rivalry (sexual selection); and (2) larger interlimb lengths in females

Pharyngeal function was studied in 31 patients with rheumatoid arthritis. Eighteen of these patients had dysphagia. Cervical spine abnormalities were present in 14. Destruction of the capitulum and/or ramus of the mandible was registered in 9. Pharyngeal dysfunction was revealed in 20. Patients with a vertical dislocation of the C1-C2 in relation to the occipital bone and patients with destruction

Background: The performance of creatinine-based glomerular filtration rate (GFR) estimating equations may vary in subgroups defined by GFR, age and body mass index (BMI). This study compares the performance of the Modification of Diet in Renal Disease (MDRD) study and Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations with the revised Lund-Malmo equation (LM Revised), a new equa

While the theoretical description of population transfer subsequent to electronic excitation in combination with a line shape function description of vibrational dynamics in the context of 2D-spectroscopy is well-developed under the assumption of different timescales of population transfer and fluctuation dynamics, the treatment of the interplay between both kinds of processes lacks a comprehensiv

The thorough experimental characterization of a dowel-type connection under various combinations of bending moments and normal forces is presented in this study. Double-shear steel-to-timber connections with 12 and 20 mm steel dowels were tested in a 4-point bending test set-up. The load, between the connected steel and wood beams, was transferred by the dowels themselves and also via an additiona

A major bottleneck in high-throughput protein production is the validation step, which is why parallel and automated sample processing methods are highly desirable. Also, a miniaturized sample preparation format is preferred, as the reduction of reagent volumes significantly decreases the analysis cost per sample. We have developed an automated and miniaturized protein sequence verification protoc