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Introduction: Synaptic dysfunction and degeneration are central events in Alzheimer's disease (AD) pathophysiology that are thought to occur early in disease progression. Synaptic pathology may be studied by examining protein biomarkers specific for different synaptic elements. We recently showed that the dendritic protein neurogranin (Ng), including the endogenous Ng peptide 48 to 76 (Ng(48-76)),
Background: We used a computational method to quantitatively investigate the relationship between personality and written narratives of life events. Agentic (i.e., self- directedness), communal (i.e., cooperativeness), and spiritual (self-transcendence) traits were of special interest because they represent individual differences in intentional val- ues and goals, in contrast to temperament traits
Background: Mild to moderate cognitive impairment is common amongst long-term survivors of cardiac arrest. In the Target Temperature Management trial (TTM-trial) comatose survivors were randomized to 33 degrees C or 36 degrees C temperature control for 24 hours after cardiac arrest and the effects on survival and neurological outcome assessed. This protocol describes a sub-study of the TTM-trial i
Predation is a major cause of breeding failure in bird species with open nests. Although many studies have investigated nest predation rates, direct identification of nest predators is sporadic, especially in (semi-)natural habitats. We quantified nest success and identified nest predators in a population of Skylarks Alauda arvensis and Woodlarks Lullula arborea breeding in a protected semi-natura
Popular Abstract in Swedish Kroppens immunförsvar brukar delas in i det medfödda och det adaptiva immunförsvaret. Det medfödda immunförsvaret reagerar snabbt på yttre hot såsom bakterier. Olika sorters vita blodkroppar är väldigt viktiga för detta snabba svar på infektion och i min avhandling har jag koncentrerat mig på en av dessa; neutrofilen. Neutrofilen är den vita blodkropp som först koNeutrophil elastase (NE) has important roles in innate immunity, killing pathogens and controlling the immune response; but how NE is targeted to developing granules is not understood. Therefore, the aim of this thesis was to investigate the sorting of NE. Transfection experiments in a leukemic cell line, which were confirmed in normal hematopoietic cells, showed that a population of proNE was ta
The objective of the study was to assess sense of coherence (SOC) many years after traumatic brain injury (TBI) and explore the relationship between SOC and self-rated life satisfaction (LS) as well as measures of functioning and disability, sex, age at injury, injury severity and time post-injury. Sixty-six individuals (aged 18-65 years) who were 6-15 years post-injury were interviewed. Data on S
Popular Abstract in Swedish Närmare 30.000 svenskar drabbas årligen av stroke (slaganfall). I ungefär 85 % av fallen är orsaken en blodpropp i ett av hjärnans kärl s.k. hjärninfarkt. En avstängning av blodflödet orsakar en snabbt insättande förlust av funktionen i det drabbade området, t.ex. halvsidig förlamning, bortfall av delar av synfältet liksom störning av olika högre hjärnfunktioner såsom mAbstract Stroke is the third leading cause of death in the western world, and the number one cause of disability. 85% of all strokes are ischemic. Most stroke survivors will experience recovery of function. The mechanisms behind this improvement are partly unknown, but may involve elements of both compensation and restoration. Exposure to an enriched environment (EE) that stimulates social interac
Popular Abstract in Swedish Tjugo patienter som deltog i psykiatrisk öppenvård baserad på arbetsterapi undersöktes beträffande behandlingsresultat, uppfattningen om vårdklimatet och upplevelsen av behandlingsrelationen med arbetsterapeuten. Psykiatriska symtom, global mental hälsa, livskvalitet och fungerandet i dagligt liv studerades vid inskrivning i behandlingen, vid utskrivning, samt vid en etThe outcomes of 20 patients participating in occupational group therapy at a psychiatric outpatient unit were explored and related to perceptions of the ward atmosphere and the treatment process. The outcome variables - psychiatric symptoms, global mental health, quality of life, and occupational functioning - were measured at admission, at discharge, and 1 year after discharge. The ward atmospher
We report on charged hadron production in deuteron-gold reactions at roots(NN) = 200 GeV. Our measurements in the deuteron direction cover 1.4
Abstract in UndeterminedA new phantom has been designed that can provide simultaneously different target to background activity ratios with a linearly changing diameter of lesions. The purpose of the study was to describe and perform initial measurements with the phantom aimed to characterize different nuclear medicine tomographic systems and reconstruction algorithms in their performance and beha
Objective: To design an economic model describing the costs and outcomes for patients treated with tumour necrosis factor alpha ( TNF alpha) inhibitors for rheumatoid arthritis ( RA) in current clinical practice in Sweden, to be used as a tool to estimate cost- effectiveness of the next generation of treatments. Methods: The model was constructed as a discrete event simulation ( DES) model analyse
In recent decades, the dominant planning discourse has undergone a great change from a previous top-down approach towards collaborative and communicative planning. Instead of merely planning for the people in a technocratic and positivist approach, planners are increasingly expected to pay attention to the voices of the citizens. However, within this new participatory approach there is a growing p
We investigated the effects of a single course of antenatal betamethasone on cognition- and anxiety-related behavior and synaptophysin and microtubule-associated protein 2 (MAP2) immunoreactivity in the adult rat hippocampus. On d 20 of gestation, pregnant rats were injected with either 1) 170 mu g/kg body weight of betamethasone ("clinically equivalent dose," equivalent to 12 mg twice, 24 h apart
