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In Huntington's disease (HD), the mutant huntingtin protein is ubiquitously expressed. The disease was considered to be limited to the basal ganglia, but recent studies have suggested a more widespread pathology involving hypothalamic dysfunction. Here we tested the hypothesis that expression of mutant huntingtin in the hypothalamus causes metabolic abnormalities. First, we showed that bacterial a
Background: It is known that, in vitro, human skin bacteria are able to split disperse azo dyes into the corresponding aromatic amines, some of which are sensitizers in the local lymph node assay. We hypothesize that the molecules of disperse dyes migrate onto the skin while garments are worn, and are metabolized and degraded by commensal skin bacteria. These molecules penetrate the skin and induc
Huntington's disease (HD) is a fatal neurodegenerative disorder caused by an expanded CAG repeat in the huntingtin (htt) gene. Neuropathology is most severe in the striatum and cerebral cortex. As mutant htt is ubiquitously expressed, it has not been possible to establish clear structure-to-function relationships for the clinical aspects. In the present study, we have injected recombinant adeno-as
The effect of selenium supplementation of feed on the Se content in bovine milk, whey and plasma, and on the distribution of Se, Zn and Cu in whey and plasma was investigated. In a cross-over study two groups of cows were given a basal feed with 0.16 ppm selenite (approx. 3 mg Se/d) with or without 25 mg yeast Se/d for 2 weeks. In the supplemented group the Se content increased 10-fold in milk, 10
Huntington disease (HD) is a fatal neurodegenerative disorder caused by expansion of a CAG repeat in the HD gene. Degeneration concentrating in the basal ganglia has been thought to account for the characteristic psychiatric symptoms, cognitive decline and motor dysfunction. However, the homeostatic control of emotions and metabolism are disturbed early in HD, and focused studies have identified a
Dopamine replacement for Parkinson's disease (PD) have seen three major iterations of improvements since the introduction of l-3,4-dihydroxyphenylalanine (l-DOPA) pharmacotherapy: dopamine receptor agonists, ex vivo gene transfer for cell transplantation and most recently in vivo gene therapy. In this chapter, we describe the principles behind viral vector-mediated enzyme replacement in PD. We foc
In this paper, we study the trade-off between complexity and performance in massive MIMO systems with neural-network based digital pre-distortion (NN-DPD) blocks at the base station. In particular, we consider a multi-user massive MIMO system with per-antenna NN-DPDs, each with an adjustable NN architecture in terms of the size and the number of NN hidden layers. We first analyze the system perfor
The semiconductor technology development con- stantly enables integrated circuits (ICs) with more, faster and smaller transistors. While there are many advantages, there are also many and new challenges, for example tighter margins, wear- outs and process variations. To address these challenges, the traditional approach with external test instruments used at man- ufacturing test must be complement
Governments are increasingly utilising research and innovation (R&I) policy to foster economic and societal change. Yet, the empirical correlation between these policies and socio-technical transformations remains under-explored. The report investigates this relationship by comparing the Recovery and Resilience Plans (RRPs) of Austria, Finland and Sweden, initiated under the NextGenerationEU f
Advanced cellular communication systems provide increased potential for opportunistic high-accuracy positioning. In this paper, long-term evolution (LTE) downlink signals from two commercial base stations (BS) are received by a massive antenna array mounted on a passenger vehicle. Multipath component (MPC) parameters, like delays and angle-of-arrival (AOA) are extracted from the received signals o
Projektet redovisas med en beskrivning och analys av arbetet med att leda ett lärarlag som här definieras som ett community of practice (Etienne Wenger 1988) med målet att genom ett sådant kollegiearbete gemensamt utveckla ett ändamålsenligt campus ethos för våra masterstudenter (Adrianna Kezar 2007). Mina erfarenheter och reflektioner kring arbetet med att leda och skapa möjligheter för samarbete
Conflicting evidence exists regarding the association between saturated fatty acids (SFAs) and type 2 diabetes. In this longitudinal case-cohort study, we aimed to investigate the prospective associations between objectively measured individual plasma phospholipid SFAs and incident type 2 diabetes in EPIC-InterAct participants.
The catechol-O-methyltransferase (COMT) gene occurs as two polymorphic alleles, which code for a high activity thermostable and low activity thermolabile form of the enzyme. We devised a fast solid-phase minisequencing assay for genotyping the COMT gene at nucleotide position 544 encoding amino acid residue 158. The method was applied to correlate the genotype of the COMT gene with the biological
Background: Existing working heart models for ex vivo functional evaluation of donor hearts often use cardiac afterloads made up of discrete resistive and compliant elements. This approach limits the practicality of independently controlling systolic and diastolic aortic pressure to safely test the heart under multiple loading conditions. We present and investigate a novel afterload concept design
Recent years have seen growing interest in leveraging deep learning models for monitoring epilepsy patients based on electroencephalographic (EEG) signals. However, these approaches often exhibit poor generalization when applied outside of the setting in which training data was collected. Furthermore, manual labeling of EEG signals is a time-consuming process requiring expert analysis,
BACKGROUND: The risk of venous thromboembolism is high after total hip arthroplasty and could persist after hospital discharge. Our aim was to compare the use of rivaroxaban for extended thromboprophylaxis with short-term thromboprophylaxis with enoxaparin.METHODS: 2509 patients scheduled to undergo elective total hip arthroplasty were randomly assigned, stratified according to centre, with a comp
The state-of-the-art machine learning techniques come with limited, if at all any, formal correctness guarantees. This has been demonstrated by adversarial examples in the deep learning domain. To address this challenge, here, we propose a scalable robustness verification framework for Deep Neural Networks (DNNs). The framework relies on Linear Programming (LP) engines and builds on decades of adv
