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Background: Markov models are models used to describe movement of individuals between states. In medicine, Markov models are used to describe, for example, disease progression and the effects of interventions on such progression. The models can further be used to identify medical risk groups and aid clinicians in clinical decision making. Although accurate individual predictions are crucial for ut
The non-collective and collective high-spin configurations in selected A ∼ 90 (Z = 42-45, N = 46-49) nuclei are analysed within the configuration-dependent shell-correction approach using the cranked Nilsson potential. With this method, various high-spin features, such as shape coexistence, shape changes, band termination and superdeformation are studied along the yrast line. We concentrate on the
The Velika Vrbica loess-palaeosol sequence, situated on the south-western bank of the Danube River in northeastern Serbia, represents one of the key Quaternary records in the lower Danube basin, covering the MIS 5-MIS 1 period. Previous investigations of the upper 500 cm established a high-resolution chronology and revealed unexpected patterns of dust accumulation during interstadial phases. In th
Covariate modeling provides individual predictions of outcomes by disease progression models. Current methodology for mapping covariates onto model parameters is limited by predefined parametric functions which can result in inadequate covariate selection and biased predictions by the final model. Furthermore, present methodology scales poorly to high-dimensional data due to combinatorial limitati
Time-interleaved ADCs are a key building block in mm-wave receivers, where the use of multi-GHz signal bandwidths requires high-performance wide-band data conversion. It is therefore necessary to explore the beamforming receiver system impact of different time-interleaved ADC parameters and limitations, such as number of interleaved channels, mismatches between channels, non-idealities of the subA
Aims Endotypes integrate individual clinical and molecular data and can be used to formulate molecular subclassifications of diseases. We previously derived four endotypes of subclinical carotid atherosclerosis in a large European cohort, c-IMT and c-IMT Progression as Predictors of Vascular Events in a High-Risk European Population (IMPROVE), identifying individuals with a specific cardiovascular
This article presents a theoretical framework for deriving simple analytical expressions for spurs resulting from second and third order nonlinearities in fractional-N phase locked loops (PLL). Furthermore, a previously proposed linearization technique where several sigma-delta modulators (SDMs) operate in parallel with relative time offsets between them, is further analyzed using the periodic non
Background: In patients resuscitated after cardiac arrest, a higher mean arterial pressure (MAP) may increase cerebral perfusion and attenuate hypoxic brain injury. Here we present the protocol of the mean arterial pressure after cardiac arrest and resuscitation (MAP-CARE) trial aiming to investigate the influence of MAP targets on patient outcomes. Methods: MAP-CARE is one component of the Sedati
In this paper, we consider near-field localization and sensing with an extremely large aperture array under partial blockage of array antennas, where spherical wavefront and spatial non-stationarity are accounted for. We propose an Ising model to characterize the clustered sparsity feature of the blockage pattern, develop an algorithm based on alternating optimization for joint channel parameter e
The 2021 edition of Lund Architecture Symposium (LAS21) will address the emergence of transformatory practices in architecture.The pressing contemporary challenges in global discourse require architects to dissolve – even obliterate – the conventional boundaries between design and implementation. These transformatory practices combine multiple skills from various industries to advance the conjavas
Background: Mammography screening programmes have been widely implemented across European countries over the past 40 years with the main aim to detect breast cancer earlier and thereby reduce breast cancer mortality. This study aimed to analyse and compare changes over time in breast cancer incidence, by stage at diagnosis, and breast cancer mortality across countries in relation to the timing of
In 1994, the Agreement on Trade-Related Aspects of Intellectual Property Rights (TRIPS) was adopted as part of the Agreement Establishing the World Trade Organization (WTO). Pursuant to the TRIPS Agreement copyright protection of computer programs for the first time had received explicit recognition on the international level. Despite obligating all WTO Members to protect computer programs as lite
Introduction: It remains unclear whether offering psychiatric patients their preferred treatment influences outcomes at the symptom level. Objective: To assess whether offering patients with Panic Disorder with/without Agoraphobia (PD/A) a choice between two psychotherapies yields superior outcomes to random assignment. Methods: In a doubly randomised, controlled preference trial (DRCPT), 221 adul
The present study argues that political communication on social media is mediated by a platform’s digital architecture—the technical protocols that enable, constrain, and shape user behavior in a virtual space. A framework for understanding digital architectures is introduced, and four platforms (Facebook, Twitter, Instagram, and Snapchat) are compared along the typology. Using the 2016 U.S. elect
