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Recombinant adeno-associated virus (rAAV) is a mammalian virus that has been altered to be used as a gene delivery vehicle. Several changes to the viral genome have made them replication deficient so that this aspect of the viral infection cycle is under full control of the experimenter, while maintaining gene expression machinery. Over the last decades, rAAVs have become the gold standard for stu
BACKGROUND & AIMS: Although colorectal cancer (CRC) screening guidelines acknowledge the need for earlier screening for high-risk individuals, such as those with family history of CRC, there is limited information on how many years earlier these high-risk individuals should be screened; current practice is based on weak evidence. We aimed to provide risk-adapted recommendations on the starting
Background: Although effective return-to-work (RTW) interventions are not widely available for individuals with common mental disorders on sick leave, there is potential for transforming such interventions into a digital solution in an effort to make them more widely available. However, little is currently known about the viewpoints of different stakeholder groups, which are critical for successfu
To figure out the abnormal flow characteristics and thermal performance of supercritical fluids, some detailed information of supercritical pressure n-decane flowing in a horizontally round pipe is studied in terms of secondary flow induced by the huge density change or buoyancy force. According to an evaluation of turbulence models, the shear stress transport k-ω is suitable to execute the case o
Background Coronavirus disease 2019 (COVID-19) is a rapidly spreading disease that has caused extensive burden to individuals, families, countries, and the world. Effective treatments of COVID-19 are urgently needed. Methods and findings This is the first edition of a living systematic review of randomized clinical trials comparing the effects of all treatment interventions for participants in all
OBJECTIVES: Low or high sympatho-adrenal-medullary axis (SAM) and hypothalamic-pituitary-adrenal axis (HPA) dysregulation reflect chronic stress. Retinal vessel dynamics may relate to SAM, HPA activity and stroke risk. Our objectives were therefore to assess the relationships between retinal vessel, SAM and HPA responses, and to determine stroke risk.METHODS: A prospective bi-ethnic gender cohort
This paper presents a search for new heavy particles decaying into a pair of top quarks using 139 fb−1 of proton-proton collision data recorded at a centre-of-mass energy of s = 13 TeV with the ATLAS detector at the Large Hadron Collider. The search is performed using events consistent with pair production of high-transverse-momentum top quarks and their subsequent decays into the fully hadronic f
Objective: To evaluate mid-term survival in patients undergoing elective fenestrated endovascular aneurysm repair and standard endovascular aneurysm repair for abdominal aortic aneurysm. Methods: Consecutive patients treated from 2007 to 2011 with elective fenestrated endovascular aneurysm repair (n = 81) and endovascular aneurysm repair (n = 201) were evaluated concerning age, cardiovascular medi
In the present work Optimal Power Flow (OPF) with minimum net work losses for Iraqi National Super Grid (400kv) INSG which consist of 19 load buses and 6 generating buses was studied. The losses were calculated and compared with that in case of ordinary load flow which is equal to 37592 MW according to data of generation and load on 2/1/2003.Mathematical model using Lagrange method programmed in M
Purpose: To investigate case mix in relation to capsule complication, possible associations between case mix and operation volume, and change in case mix over time. Design: Register-based study. Participants: Swedish patients who underwent cataract surgery between 2007 and 2016. Methods: Demographics and data on ocular comorbidity, intraoperative difficulties, and capsule complications were regist
The societal costs of disasters around the world are continuing to increase and Pacific Island countries are considered some of the most vulnerable. This is primarily due to a combination of high hazard exposure coupled with a range of social, economic, physical, and political vulnerabilities. This article contributes to the growing body of work that aims to understand the causal factors of disast
This chapter examines the role that legal actors can play in promoting accountability for, and thereby potentially contributing to the reduction in the incidence of sexual assault in situations of disaster displacement, particularly in evacuation centres and temporary shelters. It argues that justice-sector actors can contribute to accountability for and a reduction in sexual assault in evacuation
This article provides a rationale for inner transformation as a key and hitherto underresearched dimension of sustainability transformations. Inner transformation relates to various aspects of human existence and interactions such as consciousness, mindsets, values, worldviews, beliefs, spirituality and human–nature connectedness. The article draws on Meadows’ leverage points approach, as places t
This paper reports on Monte Carlo simulation results for future measurements of the moduli of time-like proton electromagnetic form factors, | GE| and | GM| , using the p¯ p→ μ+μ- reaction at P ¯ ANDA (FAIR). The electromagnetic form factors are fundamental quantities parameterizing the electric and magnetic structure of hadrons. This work estimates the statistical and total accuracy with which th
The main goal of this article is to evaluate the relationship between the spatial distribution of the population of the city of Belo Horizonte, one of the largest cities in South America, and its public transport network, seeking to ascertain whether the current bus network is able to meet the needs of the population. The methodology was based on data processing and vector information from differe
A search for a Higgs boson produced via vector-boson fusion and decaying into invisible particles is presented, using 20.3 fb−1of proton-proton collision data at a centre-of-mass energy of 8 TeV recorded by the ATLAS detector at the LHC. For a Higgs boson with a mass of 125 GeV, assuming the Standard Model production cross section, an upper bound of 0.28 is set on the branching fraction of H → inv
Background: Recent analyses in Greenlandic Inuit identified six genetic polymorphisms (rs74771917, rs3168072, rs12577276, rs7115739, rs174602 and rs174570) in the fatty acid desaturase gene cluster (FADS1-FADS2-FADS3) that are associated with multiple metabolic and anthropometric traits. Our objectives were to systematically assess whether dietary polyunsaturated fatty acid (PUFA) intake modifies
In the process of object-based change detection (OBCD), scale is a significant factor related to extraction and analyses of subsequent change data. To address this problem, this paper describes an object-based approach to urban area change detection (CD) using rotation forest (RoF) and coarse-to-fine uncertainty analyses of multi-temporal high-resolution remote sensing images. First, highly homoge
