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Severe appetite and weight loss define the eating disorder anorexia nervosa, and can also accompany the progression of some neurodegenerative disorders such as amyotrophic lateral sclerosis (ALS). Although acute loss of hypothalamic neurons that produce appetite-stimulating neuropeptide Y (Npy) and agouti-related peptide (Agrp) in adult mice or in mice homozygous for the anorexia (anx) mutation ca
The thiol activity of pancreatic islets was spectrophotometrically assayed as the formation of 6-mercaptonicotinic acid from the organic disulfide, 6, 6’-dithiodinicotinic acid. Islets containing more than 90% β-cells were microdissected from non-inbred oblob-mice. Comparisons of intact with homogenized islets indicated that the organic disulfide penetrates relatively slowly into the β-cells. When
Bacterial ice-nucleating particles (INP) are present in the atmosphere and efficient in heterogeneous ice-nucleation at temperatures up to -2 °C in mixed-phase clouds. However, due to their low emission rates, their climatic impact was considered insignificant in previous modeling studies. In view of uncertainties about the actual atmospheric emission rates and concentrations of bacterial INP, it
Prospective observational studies have shown previously that study participants have lower morbidity and mortality than non-participants. The aim of the current study was to determine whether participants in a prospective cohort study on melanoma have a different incidence and mortality of melanoma compared with non-participants and the background population. Information was collected from Swedish
Background: IRL752 is a novel small-molecule compound that acts to regioselectively enhance norepinephrine, dopamine, and acetylcholine neurotransmission in the cerebral cortex. Objective: The primary objective of the trial was to investigate the safety and tolerability of IRL752 in patients with Parkinson's disease and dementia. Methods: Patients with Parkinson's disease and dementia were randomi
The rooms in Intensive Care Units are considered as high-tech environments and believed to affect recovery process and wellbeing of patients. Moreover, the design and interiors affect the interplay between the patient and the next of kin. Objective: The aim of this study was to describe and interpret the meanings of the intensive care patient room as experienced by next of kin. Design: Next of kin
High sound levels related to medical equipment and high activity day and night, is a wellknown phenomenon in intensive care units (ICUs). This may result in poor sleep and prolonged recovery for the patients but may also be a precipitating factor for intensive care delirium (ICU delirium).The aim of this pilot study was to describe patients' responses to the sound environment in an ICU and to iden
The immune cell population is essential for understanding the immune system’s reaction against the tumor. This study identified T cells and myeloid cells in human papillomavirus positive and negative tonsillar cancer biopsies via extracellular markers to investigate the biopsies’ composition, cellular neighborhood, and interactions. A detection method for tertiary lymphoid structure was developed.
Climate change and socio-economic developments are projected to intensify land use pressures in northern latitudes, potentially driving agricultural expansion into Arctic and boreal ecosystems. This thesis examines the consequences of future climate and land use change on ecosystem services in the European Arctic, focusing on vegetation dynamics, carbon storage, crop productivity, and biophysical
Hållbarhet har under de senaste åren fått en allt större betydelse, då den globala uppvärmningen utgör en av vår tids största utmaningar. Fastighets- och byggsektorn står totalt för 40% av den totala energikonsumtionen i Europa. EU arbetar aktivt för att minska energiförbrukningen i byggnader genom direktivet om byggnaders energiprestanda (EPBD). Det långsiktiga målet med direktivet är att unionenSustainability has become increasingly important in recent years as global warming continues to be the most serious threat to our environment. The real estate sector accounts for 40 percent of the total energy consumption in Europe. To address this issue, the European Union initiated the Energy Performance of Buildings Directive (EPBD), which aims to reduce energy consumption and achieve a fully d
This thesis explored how large Swedish organizations leverage continuous learning to enhance organizational agility in response to the challenges of operating in a VUCA (Volatile, Uncertain, Complex, and Ambiguous) world. The aim was to examine how learning initiatives are enhancing and sustaining organizational agility in two case companies, one in entertainment technology and one in industrial t
The Palestinian refugee question is one of the most protracted and politically charged refugee crises of modern times and in modern history. Palestinian refugees in Lebanon have endured generations of statelessness, constrained by exclusionary legal frameworks. This study examines the condition of statelessness among Palestinian refugee youth in Lebanon and the formation of political agency and ev
This study examines how small states construct and perform diplomatic roles in the United Nations Security Council (UNSC), focusing on the 2023 tenures of Albania, Malta, and Switzerland. Using a theory-driven content analysis informed by constructivism, role theory, and the concept of niche diplomacy, the study explores how these states advanced national interests and projected identity within a
This thesis examines how offensive realism can explain China’s violations of international law in the South China Sea (SCS). Drawing on John Mearsheimer’s five bedrock assumptions: anarchy, offensive capability, uncertainty of intentions, survival as a primary goal, and rationality, the study uses the congruence method within a qualitative case study framework. It assesses whether China’s violatio
As Sweden expands and modernizes its railway network, the design of durable and cost- efficient railway bridges becomes increasingly important. A central technical challenge in this context is track-bridge interaction (TBI), the mechanical interplay between the rail and bridge structure. This interaction affects how forces from traffic loads, temperature variations and braking are transferred with
Även om det internationella straffrättssystemet vilar på ett grundläggande uppdrag att sätta stopp för straffriheten för de allvarligaste brotten, är det rättsliga ramverket för den Internationella brottsmålsdomstolen (ICC) fortfarande strikt begränsat till åtal mot fysiska personer enligt artikel 25. Samtidigt har multinationella företag i allt högre grad blivit föremål för nationella åtal för siWhile the international criminal justice system is anchored in a foundational mandate to end impunity for the most serious crimes, the statutory framework of the International Criminal Court (ICC) remains strictly limited to the prosecution of natural persons under Article 25. At the same time, multinational corporations have increasingly been subject to domestic prosecutions for their role in int
Despite increased scholarly attention on civilian victimisation in recent years, this research often categorises all civilians into one homogeneous group, thus obscuring the differentiation within, particularly that of children. This study addresses this gap by examining the underlying logic of targeting children in war. The study examines the case of Russian deportations of Ukrainian children and
