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RelA/SpoT Homologue (RSH) proteins, named for their sequence similarity to the RelA and SpoT enzymes of Escherichia coli, comprise a superfamily of enzymes that synthesize and/or hydrolyze the alarmone ppGpp, activator of the "stringent" response and regulator of cellular metabolism. The classical "long" RSHs Rel, RelA and SpoT with the ppGpp hydrolase, synthetase, TGS and ACT domain architecture
This study shows the distribution patterns of apoptotic cells and biomarkers of cellular senescence during the ontogeny of the retina in the zebra finch (T. guttata). Neurogenesis in this altricial bird species is intense in the retina at perinatal and post-hatching stages, as opposed to precocial bird species in which retinogenesis occurs entirely during the embryonic period. Various phases of pr
Low-power wearable technologies offer a promising solution to pervasive epilepsy monitoring by removing the constraints concerning time and location, on one hand, and fulfilling long-term tracking, on the other hand. In the case of epileptic seizures, as the attacks infrequently occur, using an anomaly detection approach reduces the need to record long hours of data for each patient before detecti
In this study, Zr-pillared montmorillonite clays (Zr-PILCs) were synthesized using two different precursor materials: raw montmorillonite (CM) and sodium ion-saturated montmorillonite (Na-CM) at different Zr/clay ratios (2.5, 5 and 10 mmol/g). To study the effect of Zr concentration and clay pre-treatment with NaCl on pillaring, the modified clay samples were characterized in detail using X-ray di
Algorithms used for the reconstruction and identification of electrons in the central region of the ATLAS detector at the Large Hadron Collider (LHC) are presented in this paper; these algorithms are used in ATLAS physics analyses that involve electrons in the final state and which are based on the 2015 and 2016 proton–proton collision data produced by the LHC at s = 13 TeV. The performance of the
Legitimacy is necessary for resilience and trust helps to legitimize health systems. Providing services during Covid has relied on both the private and public sectors but there is little information on differences in trust between these sectors during shocks like Covid and how it may impact the health system’s legitimacy. The purpose of this study was to explore community trust in the public and p
Background: The ongoing Pan-European Real Life (PEARL) phase 4 study is evaluating fremanezumab effectiveness and safety for the prevention of episodic and chronic migraine. This interim analysis reports primary, secondary and exploratory endpoints from when 500 participants completed at least six months of treatment. Methods: Adults with episodic migraine or chronic migraine maintaining daily hea
In 20 CE, Aemilia Lepida was tried before the senatorial court. When the court recessed for a holiday, she rallied support by referring to her Pompeian ancestry, choosing as her venue the theatre built by her great-grandfather Pompey himself. Accompanied by a group of fellow elite women (clarae feminae), Lepida entered the theatre and invoked the imagines of her great ancestor with tearful lamenta
In spite of the similar structural and genomic organization of human immunodeficiency viruses type 1 and 2 (HIV-1 and HIV-2), striking differences exist between them in terms of replication dynamics and clinical manifestation of infection. Although the pathomechanism of HIV-1 infection is well characterized, relatively few data are available regarding HIV-2 viral replication and its interaction wi
Studies on patients with bladder outflow obstruction who have undergone surgery for benign prostatic hyperplasia, successfully relieving the obstruction, have revealed a persistence of storage symptoms associated with detrusor overactivity (DO) in 20% to 40% of patients. To study the underlying mechanisms, we have used a common rat model of obstruction/de-obstruction, assuming that non-voiding con
Background: Remote symptom monitoring (RSM) is an evidence-based strategy shown to mitigate postoperative morbidity; however, platform engagement is required to benefit from RSM. Patients who report current smoking are at high risk for postoperative complications, but it is unknown whether smoking status influences engagement with RSM, symptom severity, or unanticipated acute care visits. Methods:
Objective: Following the favorable outcomes demonstrated by the Early MiNimally-invasive Removal of IntraCerebral Hemorrhage (ENRICH) trial in supratentorial intracerebral hemorrhage (ICH) patients treated with minimally invasive surgery (MIS), and considering the increasing interest in MIS, we aimed to assess the potential eligibility rate for ICH patients in Sweden. Methods: All patients with sp
A search for the production of three Higgs bosons ((Formula presented)) in the (Formula presented) final state is presented. The search uses (Formula presented) of proton-proton collision data at (Formula presented) collected with the ATLAS detector at the Large Hadron Collider. The analysis targets both nonresonant and resonant production of (Formula presented). The resonant interpretations prima
Influenced by climate warming and sea-level rise, seacoasts in many parts of the world are undergoing regime shifts, including increased coastal erosion in the southeastern Baltic Sea. The aim of this study is to reconstruct the depositional and erosional history of the Järve coastal scarp using sediment stratigraphy, new luminescence and radiocarbon dates, ground-penetrating radar, and LiDAR data
A set of measurements for the production of a W-boson in association with high-transverse-momentum jets is presented using 140 fb-1 of proton–proton collision data at a centre-of-mass energy of s=13 TeV collected by the ATLAS detector at the LHC. The measurements are performed in final states in which the W-boson decays into an electron or muon plus a neutrino and is produced in association with j
