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In the 1990s it was discovered that the enzyme dipeptidyl peptidase-4 (DPP-4) inactivates the incretin hormones glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). DPP-4 inhibition results in raised levels of the two incretin hormones which in turn result in lowering of circulating glucose through stimulation of insulin secretion and inhibition of glucagon secre
Objectives: Pregnancy can influence immune control of Mycobacterium tuberculosis infection (MtbI). We recently reported an association between MtbI and pregnancy complications, particularly severe preeclampsia, in a registry-based cohort of women originating in tuberculosis-endemic countries screened for MtbI in Swedish antenatal care, implying a potential role of MtbI for the development of preec
It is unclear if the results of randomised controlled trials (RCTs) of behaviour therapy (BT) for Tourette syndrome (TS) and chronic tic disorder (CTD) can be generalised to naturalistic clinical settings and are durable long-term. In this naturalistic study, 74 young people with TS/CTD received BT at a specialist clinic. Data were collected at baseline, post-treatment, and at 3-, 6-, and 12-month
This chapter focuses on the dominantly gendered house-help in India: the cooks, cleaners, and maids during the pandemic-triggered lockdowns in Delhi and its metropolitan areas. Even if we are scared to enter people's homes, we have to come out to work to sustain our lives. The case studies of these three women point to the precarity and 'unrepresentability' which turn the previously invisible figu
ESSnuSB is a design study for an experiment to measure the CP violation in the leptonic sector at the second neutrino oscillation maximum using a neutrino beam driven by the uniquely powerful ESS linear accelerator. The reduced impact of systematic errors on sensitivity at the second maximum allows for a very precise measurement of the CP violating parameter. This review describes the fundamental
The aim of this paper is to provide an explanation to why the degree of informal employment may vary substantially between different regions within a country. In Brazil, 45% of workers in the urban labor force are employed informally. The degree of informal employment, however, varies substantially across regions, with some cities having 20% and others having 80% or more of their labor force in th
Mutations are not identified in ~5% of hemophilia A and 10-35% of type 1 VWD patients. The bleeding tendency also varies among patients carrying the same causative mutation, potentially indicating variants in additional genes modifying the phenotype that cannot be identified by routine single-gene analysis. The F8, F9 and VWF genes were analyzed in parallel using an AmpliSeq strategy and Ion Torre
This study assesses the effect of some extended Enterprise Resource Planning (ERP) capabilities (Collaboration, Analytics, Web-portals, Add-ons) and ERP use on ERP value. The research conducted, followed a mixed-methods approach using an exploratory study (Delphi) and the resource-based view of the firm to understand the ERP capabilities and develop three competing models surrounding these capabil
To ensure that listeners pay attention and do not habituate, emotionally intense vocalizations may be under evolutionary pressure to exploit processing biases in the auditory system by maximising their bottom-up salience. This “salience code” hypothesis was tested using 128 human nonverbal vocalizations representing eight emotions: amusement, anger, disgust, effort, fear, pain, pleasure, and sadne
Language is a powerful tool in the creation of social identities. This work analyses the security policy discourses of two major actors in world politics: the European Union and the United States. The material is composed of security documents of both actors ranging from the time before the 9/11 terrorist attacks to present day. Discourse analysis, especially its Foucauldian strand emphasising the
Prior to the end of the Cold War, China's foreign policy was in large shaped by a confrontational, power-based discourse. However, since the early 1990s, China's foreign policy in general and its regional policy in particular has undergone significant change. Today, China operates in large with, and within major international and regional institutions and regimes. This is also notable conc
