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Rational, autonomous agents that are able to achieve their goals in dynamic, partially observable environments are the ultimate dream of Artificial Intelligence research since its beginning. The goal of this PhD thesis is to propose, develop and evaluate a framework well suited for creating intelligent agents that would be able to learn from experience, thus becoming more efficient at solving thei

A capillary filling microfluidic proteomic sample processing system has been realized in an automated set-up. Chip-integrated solid-phase extraction is performed in a 96-array format followed by sequential capillary action elution into a piezoelectric microdispenser and subsequent transfer to MALDI targets. Samples are eluted and deposited in volumes of 200–300 nl. The robotic system offers calibr

Study commissioned by BIL Sweden for the Committee for Producer Responsibility Review (M 2000:01) på uppdrag av BIL Sweden

Many problems concerning resource management in modern communication systems can be simplified to queueing models under Markovian assumptions. The computation of the optimal policy is however often hindered by the curse of dimensionality especially for models that support multiple traffic or job classes. The research focus naturally turns to computationally efficient bounds and high performance he

Objective: To evaluate long-term oncological outcome and surgical quality of robotic radical hysterectomy for cervical cancer. Methods: Consecutive women with stage IA2 to IIA operated between March 2006 and May 2012 with a robotic radical hysterectomy and pelvic lymphadenectomy were prospectively followed up until five years after surgery or until death. Details regarding clinical results, recurr

A general mixed initial-boundary value problem for a non-local hyperbolic equation, relevant for the study of the propagation of transient electro-magnetic waves in flat slabs, consisting of dispersive stratified complex media, and excited by incident plane waves, is treated. Theorems regarding unique solvability and causality are presented and proved by a time domain method similar to the one use

Traditional linear time-invariant (LTI) control design assumes that measurements are taken at regular time intervals and have independent additive noise. A common practical case that violates this assumption is the use of encoders that give quantized position measurements; when the quantization is appreciable the measurement noise is far from LTI. This paper develops a simple event-based controlle

Phenotypic modulation of smooth muscle cells (SMCs) plays a key role in vascular disease, including atherosclerosis. Several transcription factors have been suggested to regulate phenotypic modulation of SMCs but the decisive mechanisms remain unknown. Recent reports suggest that specific microRNAs (miRNAs) are involved in SMC differentiation and vascular disease but the global role of miRNAs in p

As the evolutionary responses to environmental change depend on selection acting on individual differences,disentangling within- and between-individual variation becomes imperative. In animalmigration research, multiyear tracks are thus needed to estimate the individual consistency of phenotypictraits. Avian telemetry studies have recently provided the first evidence of individuality acrossspace a