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For Alligator Bioscience AB, a company developing immunotherapeutic antibodies, it is crucial to efficiently evaluate a large number of potential drug candidates at an early stage. The in-house developed RUBYTM concept, combining monoclonal antibodies into bispecific antibodies without lead optimization, requires implementation of high-throughput technologies. Restriction enzyme digestion, used fo
Climate warming is expected to influence the prevalence of vector-transmitted parasites. Understanding the extent to which this is ongoing, or has already occurred, requires empirical data from populations monitored over long periods of time, but these studies are sparse. Further, vector-disease research involving human health is often influenced by disease control efforts that supersede natural t
A way to use adiabatic radiofrequency pulses and modulated magnetic-field gradient pulses, together constituting a "shim pulse," for NMR spectroscopy and imaging is demonstrated. These pulses capitalize on phase shifts derived from probe gradient coils to compensate for nonlinear intrinsic main magnetic field homogeneity for spectroscopy, as well as for deviations from linear gradients for imaging
Abstract OBJECTIVES: To investigate the effects of antenatal betamethasone on fetal and uteroplacental hemodynamics. METHODS: The study comprised 33 women with singleton high-risk pregnancies (23-33 weeks; 27 pregnancies < 30 weeks) not in labor, but at risk for preterm delivery based on fetal or maternal indications. They were treated with two doses of 12 mg betamethasone intramuscularly 24 h ap
Expansions of innovation policies have been paralleled with an increasein the evaluations of such policies. Yet, there are few systematic evaluations of how such evaluations are conducted, by whom, and their overall conclusions. We analyze 110 evaluations of innovation policy in Sweden from 2005 to 2019. Our findings show that the majority of these evaluations are positive, about one-third are neu
Within international investment law scholarship, increased attention has been devoted to the capacity of international investment law, which includes investment treaty arbitration, to facilitate sustainable development. Scholars increasingly agree that issues of sustainable development permeate throughout the international investment law system and thus cannot be viewed as beyond its scope and jur
This paper constructs the first long-run estimates of Irish regional GDP over the twentieth century and traces the relative economic performance of Ireland’s regions since independence. Using an array of data sources available at a county level, output in Agriculture, Industry and Services in benchmark census years is estimated. Applying a variety of alternative measures, we find a reduction in re
BackgroundShock is a condition with high mortality even with early intervention and treatment. Usual care for shock and hypotension in the Emergency Department (ED) is intravenous fluid resuscitation which can lead to fluid overload and other complications. When fluid therapy fails or risk of complications are high, the next treatment step is the use of vasopressors for stabilisation. Noradrenalin
Radiation dosimetry and cancer risk estimations are central to virtually all radiation safety applications, optimization, and research. These estimates relate to various exposure situations including planned, existing, and emergency situations. The International Commission on Radiological Protection (ICRP) has developed a new methodology to handle the dosimetry of an acute/single intake of radionu
Är det möjligt för konsumenter att vara förändringen man vill se i samhället, och därmed bidra till en hållbarare framtid? Med hjälp av en modell baserad på Multi-Regional Input-Output (MRIO) analys undersöks den miljömässiga potentialen av olika livsstilar i EU. Europeiska hushålls fotavtryck för koldioxid, toxicitet, vatten och land beräknas för olika konsumtionsmönster. Modellen som används innIs it possible for the EU consumer to ‘Be the Change’ and set society on a more sustainable pathway by a change of lifestyle? Using a Multi-Regional Input-Output (MRIO) model this research investigates the environmental impact reduction potential of different lifestyles in the EU, for footprints of carbon, toxicity, water, and land. 12 lifestyles are found that offer significant reduction potentia
Abstract The spring of 2011 unrest grew in the Middle East and North Africa, and as a result we saw a surge in in oil prices. This essay conducts an evaluation on if these kinds of geopolitical events within the OPEC have affected the oil price in the past in the same way. As a contrary variable we have also assessed if the VIX-index is a good indicator of decreasing oil prices. We have used
