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Objective Ultrasound is a promising tool to foster much-needed improvement of skin assessment in systemic sclerosis (SSc). Our aim was to develop evidence and expert opinion-based recommendations to promote the standardisation and harmonisation of technical execution and reporting of skin ultrasound studies in SSc. Methods A multidisciplinary task force of 16 members from five European countries a
The risk assessment of pesticide residues in food is a key priority in the area of food safety. Most jurisdictions have implemented pre-marketing authorization processes, which are supported by prospective risk assessments. These prospective assessments estimate the expected residue levels in food combining results from residue trials, resembling the pesticide use patterns, with food con-sumption
3D food printing is a fascinating novel technology with many promising applications, from futuristic-looking food topersonalized nutrition, and space food for astronauts. However, much of its potential is only realized in the laboratoryor speculated in the literature. This research is an attempt to explore the barriers to the diffusion of this newtechnology to the wider market. It argues that the
We present the design, prototype developments and test results of the new time-of-flight detector (ToFD) which is part of the R3B experimental setup at GSI and FAIR, Darmstadt, Germany. The ToFD detector is able to detect heavy-ion residues of all charges at relativistic energies with a relative energy precision σΔE/ΔE of up to 1% and a time precision of up to 14 ps (sigma). Together with an
In heterogeneous catalysis the reactions occur on the surface of a catalyst. To understand the reaction pathways, a detailed understanding on an atomic level is critical. However, the gas atmosphere surrounding the surface dictates the interaction between the surface and the gas. At low pressures this is often neglected, but as the community turns to higher pressures it becomes important to consid
The end-Ordovician extinction consisted of two discrete pulses, both linked, in various ways, to glaciation at the South Pole. The first phase, starting just below the Normalograptus extraordinarius Zone, particularly affected nektonic and planktonic species, while the second pulse, associated with the Normalograptus persculptus Zone, was less selective. Glacially induced cooling and oxygenation a
Most organisms that ever lived on Earth lacked skeletons and have therefore escaped preservation in the geological record. This fact makes it hard to accurately trace the evolution of multicellular organisms and the tree of life. However a handful faunas did get exceptionally well-preserved, including their soft-bodied members, just when complex lifeforms diverged 550 million years ago. Geochemica
Two mathematical models of human thermal regulation include the rational Predicted Heat Strain (PHS) and the thermophysiological model by Fiala. The approaches of the models are different, however, they both aim at providing predictions of the thermophysiological responses to thermal environments of an average person. The aim of this study was to compare and analyze predictions of the two models a
Objectives: The symptoms of Posttraumatic Stress Disorder (PTSD) and chronic pain are thought to interact to increase the severity and impact of both conditions, but the mechanisms by which they interact remain unclear. This study examines the relationship between PTSD and chronic pain and whether indices of psychological flexibility mediate the relationship between these two conditions.Methods: S
The learning curve during repetitive production and the associated forgetting during production breaks are fundamental issues in the understanding of behavior. A model is suggested that combines 3 basic findings, namely, that single memory traces decay according to a power function of the retention interval, that aggregated memory traces can be combined by integration, and that the time to produce
A process for synthesis of a polymeric polyalcohol substantially and preferably built up form polyester units and composed of a monomeric or polymeric initiator molecule to which at least one dentritic branch (dendron) consisting of a number of branching generations is added. The branching generations comprise a polymericor monomeric branching chain extender having three reactive functions of whic
Groups associated to surfaces isogenous to a higher product of curves can be characterized by a purely group-theoretic condition, which is the existence of the so-called ramification structure. In this paper, we prove that infinitely many quotients of the Grigorchuk groups admit ramification structures. This gives the first explicit infinite family of 3-generated finite 2-groups with ramification
In this chapter, the authors highlight that the challenges related to managing modern projects are that the management problems have changed since traditional project management methods were developed. This calls for new project management methods, adapted to situations of rapid technological change and flexibility. The authors identify and highlight the limitations of both traditional and agile m
This chapter rests on participant observation and interviews from Malungs folkhögskola, the distance education “Folkmusik fiol”, led by the doyen of Swedish folk music pedagogy, Jonny Soling. With his life-long experience of fiddle education for grown-ups, Soling has unique knowledge of holistic fiddle didactics. At the age of 73, he still attracts course participants from all ages and all parts o
The p53 tumor suppressor protein can induce both apoptosis and cell cycle arrest. Moreover, we and others have shown previously that p53 is a potent mediator of differentiation. For example, expression of ptsp53, a temperature-inducible form of p53, induces differentiation of leukemic monoblastic U-937 cells. The functions of p53 have for long been believed to be dependent on the transactivating c
Fix some p∈ [0 , 1] and a positive integer n. The discrete Bak–Sneppen model is a Markov chain on the space of zero-one sequences of length n with periodic boundary conditions. At each moment of time a minimum element (typically, zero) is chosen with equal probability, and it is then replaced alongside both its neighbours by independent Bernoulli(p) random variables. Let ν(n)(p) be the probability
In pre-industrial Europe, many thousands of ‘middle-class’ individuals retired by purchasing a corrody: a contract allowing them life-long food and lodging, usually by spending their remaining years in a hospital. Given that people usually struggle to prepare for the later stages of life, this article asks whether corrodies were priced in line with the market. We study institutions that specialize
FLASH radiotherapy is a novel technique that has been shown in numerous preclinical in vivo studies to have the potential to be the next important improvement in cancer treatment. However, the biological mechanisms responsible for the selective FLASH sparing effect of normal tissues are not yet known. An optimal translation of FLASH radiotherapy into the clinic would require a good understanding o
This paper addresses the topic of site characterization for the design of Shallow Geothermal Energy (SGE) systems, namely of thermoactive geostructures, which are geotechnical structures, such as piles, retaining walls and tunnel linings, also used as heat exchangers as part of closed-loop SGE systems. Such solutions, being increasingly adopted for buildings’ and infrastructures’ heating and/or co
