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Targeting the androgen receptor (AR) pathway prolongs survival in patients with prostate cancer, but resistance rapidly develops. Understanding this resistance is confounded by a lack of noninvasive means to assess AR activity in vivo. We report intracellular accumulation of a secreted antigen-targeted antibody (SATA) that can be used to characterize disease, guide therapy, and monitor response. A

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In gas turbine engine, nickel base alloy, such as Alloy 718, accounts for almost half of the total material requirement. Nickel-base superalloys are used for gas turbine components mainly because of their outstanding strength and resistance to oxidation at high temperatures (> 550°C). The massive cost involved with the machining of nickel alloys has driven continued research and development of cut