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OBJECTIVE - We assessed the association between A1C and cardiovascular diseases (CVDs) in an observational study of patients with type 1 diabetes followed for 5 years. RESEARCH DESIGN AND METHODS - A total of 7,454 patients were studied from the Swedish National Diabetes Register (aged 20-65 years, diabetes duration 1-35 years, followed from 2002 to 2007). RESULTS - Hazard ratios (HRs) for fatal/n
The Swedish Dementia Registry (SveDem) was developed with the aim to improve the quality of diagnostic work-up, treatment and care of patients with dementia disorders in Sweden.
Background: The majority of non-syndromic colorectal cancers (CRCs) can be described as a complex disease. A two-stage case-control study on CRC susceptibility was conducted to assess the influence of the ancestral alleles in the polymorphisms previously associated with nutrition-related complex diseases. Methods: In stage I, 28 single nucleotide polymorphisms (SNPs) were genotyped in a hospital-b
Background: Genome-wide association studies (GWAS) have emerged as a powerful approach for identifying susceptibility loci associated with polygenetic diseases such as type 2 diabetes mellitus (T2DM). However, it is still a daunting task to prioritize single nucleotide polymorphisms (SNPs) from GWAS for further replication in different population. Several recent studies have shown that genetic var
Purpose: We investigated the distribution of cannabinoid receptor subtypes 1 and 2 in the detrusor of different species and studied the effects of cannabinoid receptor 1 and 2 agonists on bladder function. Materials and Methods: Cannabinoid receptor 1 and 2 expression was studied with Western blot and immunohistochemistry in rat, monkey and human detrusors. Co-staining was done for markers of sens
Anthracyclines and taxanes are active cytotoxic drugs in the treatment of early metastatic breast cancer. It is yet unclear whether addition of capecitabine to the combination of these drugs improves the treatment outcome. Patients with advanced breast cancer were randomized to first-line chemotherapy with a combination of epirubicin (Farmorubicin(A (R))) and paclitaxel (Taxol(A (R))) alone (ET) o
OBJECTIVE Growth hormone (GH) deficiency is associated with insulin resistance and diabetes. The aim of the current study was to determine incidence of diabetes during GH replacement therapy (GHRT) and the effect of GHRT on fasting plasma glucose concentrations and HbA(1c) in adult patients with GH deficiency. RESEARCH DESIGN AND METHODS-A total of 5,143 GH-deficient patients (male 49.9%; mean age
The key role of tropical forest belowground carbon stocks and fluxes is well recognised as one of the main components of the terrestrial ecosystem carbon cycle. This study presents the first detailed investigation of spatial and temporal patterns of fine root stocks and fluxes in tropical forests along an elevational gradient, ranging from the Peruvian Andes (3020 m) to lowland Amazonia (194 m), w
A measurement is presented of the inclusive cross-section for b-jet production in association with a Z boson in pp collisions at a centre-of-mass energy of root s = 7 TeV. The analysis uses the data sample collected by the ATLAS experiment in 2010, corresponding to an integrated luminosity of approximately 36 pb(-1). The event selection requires a Z boson decaying into high P-T electrons or muons,
Background: Scotland possesses the worst mortality outcomes and slowest improvement in life expectancy of Western Europe. Within Scotland, stark inequalities exist in both morbidity and mortality. There remains paucity in assessment of subnational variation in disease burden. Aim: This thesis explored geographical inequalities in burden of disease (BoD) across 32 Scottish authorities. Secondary an
Introduction: Decades of nuclear activities have polluted marine environments with transuranium actinides. Background: Brown algae have frequently been used as marine bioindicators of radioactivity, but current literature describing the sequential separation and determination of Pu and Am from brown algae matrices is sparse, and does not make use of recent extraction chromatographic resins such
Lantbruket står inför stora förändringar till följd av en snabb ökning av den globala befolkningsmängden och klimatförändringar som skapar stor press på värdekedjan för matproduktion. Användningen av teknologier för precisionsodling (PA) har visat sig ha fördelar som kan vara en del av lösningen för dessa framtida utmaningar. Trots detta råder det inte konsensus inom forskarkåren om vilka aspekterThe agricultural industry is going through immense changes due to the rapid growth of the global population and climate change, creating increased pressure on the food supply chain. The use of precision agriculture (PA) technologies have shown benefits that could help solve these challenges. Despite this, there is no consensus among researchers on what aspects affect the adoption of PA technology
The purpose of this master’s thesis is to provide a contribution to the research body regarding consumer returns, particularly within the online fashion retail industry. A quantitative data analysis approach is chosen and two main methods are used: data study that aims to identify patterns and interesting relationships in the data, and a simulation study that uses real input data to attempt to ide
This thesis studies the distribution of accessibility by public transport to retail concentrations and public hospitals in Athens, using spatial autocorrelation analysis based on Local Indicators of Spatial Autocorrelation (LISA) method and Geographically Weighted Regression (GWR). For this reason, the study area was divided in a 300x300 meter square grid of points representing the location point
The search for doubly charged Higgs bosons (H±±) aims at resolving the mass generation mechanism of neutrinos in the Standard Model. The current search by the ATLAS Same-Sign Dilepton group uses the decay product of H±± to a pair of same-sign hadronic τ-leptons, which is an extension of their previous search using same-sign dielectrons and dimuons. This thesis focuses on the study of one of the ba
This thesis explores the potential of mhealth methods, seeking to understand why mhealth would be advantageous to traditional methods as a means to provide information regarding sexual and reproductive health (SRH) for youth in Kenya and what prerequisites exists for it to be successfully adopted among the youth and why. It is investigated with a qualitative approach, with the use of expert interv
This thesis investigates the decision-making process that led to the rapid adoption of small-scale hydropower projects, and its social implications, in Kosovo between 2013 and 2021. However, the fairness of the decision-making process for hydropower projects has been heavily criticized by local communities and NGOs. This research links procedural justice concerns voiced by a small community in Sou
Double taxation has been widely accepted that constitutes an obstacle to the functioning of the single market. The European Union has adopted some uniform measures to have double taxation eliminated, for example, the Parent-Subsidiary Directive and the Interest-Royalty Directive. In addition, the Arbitration Convention has been concluded between Member States to eliminate double taxation in respec
