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The development of mature B lymphoid cells involves a highly orchestrated regulation of stage- and lineage-specific genes. In this study, we report an analysis of the human surrogate L chain VpreB promoter. The promoter has an overall homology of 56% to the mouse counterpart and displays a preB cell-restricted activity in transient transfections in cell lines. The promoter harbors three independen

The aim of the present study was to examine the influence of pregnancy on deterioration of retinopathy in patients with Type 1 diabetes mellitus. Sixty-five pregnant Type 1 diabetic women attending the University Hospital in Lund were studied retrospectively. The degree of retinopathy, and levels of HbA1c and blood pressure 12 months before, during, and 6 months after pregnancy were compared of th

To investigate subjective and objective changes in function in subjects with Parkinson's disease (PD) home visits with interviews were performed with a 1-year interval. Depressive symptoms were rated with the Geriatric Depression Scale, subjective health with the generic SF-36 scale and the disease-specific PDQ-8 scale; objective changes were assessed according to the Hoehn and Yahr scale; insomni

Oncogenic mutants of c-Kit are often found in mastocytosis, gastrointestinal stromal tumors and acute myeloid leukemia. The activation mechanism of the most commonly occurring mutation, D816V in exon 17 of c-Kit, has been well-studied while other mutations remain fairly uncharacterized in this respect. In this study, we show that the constitutive activity of the exon 11 mutant V560D is weaker than

Background: The aim of this study was to evaluate the test-retest reliability and the validity of the self-reported questionnaire Olerud-Molander Ankle Score (OMAS) in subjects after an ankle fracture. Methods: When evaluating the test-retest reliability of the OMAS, 42 subjects surgically treated due to an ankle fracture participated 12 months after injury. OMAS was completed by the patients on t

Extracellular signal-regulated kinase 2 (ERK2) is located in the cytoplasm of resting cells and translocates into the nucleus upon extracellular stimuli by active transport of a dimer. Passive transport of an ERK2 monomer through the nuclear pore is also reported to coexist. We attempted to characterize the cytoplasmic retention and nuclear translocation of fusion proteins between deletion and sit

Literature will be freely distributed through the course homepage.

https://www.nateko.lu.se/sites/nateko.lu.se/files/gisn26_littlist_eng.pdf - 2026-07-20

Staphylococcal toxic shock syndrome is a potentially lethal illness attributed to superantigens produced by Staphylococcus aureus, in particular toxic shock syndrome toxin 1 (TSST-1), but staphylococcal enterotoxins (SEs) are also implicated. The genes encoding these important toxins are carried on mobile genetic elements, and the regulatory networks controlling expression of these toxins remain r

Erlotinib inhibits epithelial growth factor receptor (EGFR) kinase activity and is used to treat non-small cell lung cancer (NSCLC). Despite its high efficacy, recurrence can occur in patients who become resistant to the drug. To address the underlying mechanism of Erlotinib resistance, we investigated additional mechanisms related to mode-of-drug-action, by multiple protein-binding interactions,

As an international actor it is preferable to make an effort to understand how your performance affects the long-term sustainability, both in local and global terms. Sustainability includes subjects such as integration between economical, social and environmental spheres. It can be achieved by reorganizing living conditions, reappraising economic sectors and work practices, develop technologies in

In generally, there is a phenomenon of “free rider” in the establishment of national oil reserves for different countries, which means that they have the tendency of underestimating the strategic oil reserves. This paper attempts to explain this phenomenon from the perspective of non-cooperative game theory. It also analyzes the establishment of strategic oil reserve among different countries base

Development of B-lymphoid cells in the bone marrow is a process under strict control of a hierarchy of transcription factors. To understand the development of a B-lymphoid-restricted functional network of transcription factors, we have investigated the cell autonomous role of the transcription factor EBF1 in early B cell development. This revealed that even though transplanted EBF1-deficient fetal

an-European research infrastructures (RIs) have been labelled a ‘pillar’ of the European Research Area initiative and ‘engines’ which are expected to drive forward the European Union (EU) economy by advancing its science and technology and ultimately its competitiveness on the global arena. The focus of this article is on the origins and nature of a policy tool named the European Research Infrastr

In the philosophy of J. L. Schellenberg, “evolutionary religion” is a religious stance oriented towards the deep future. According to Schellenberg, the best form of evolutionary religion is non-doxastic faith in ultimism. I reject Schellenberg’s arguments for preferring ultimism and suggest that committing non-doxastically to traditional religion makes more sense from an evolutionary perspective.

Microsoft Word - GEON02.doc Literature for Quaternary Geology: GEON02 Palaeoecological methods and environmental analysis, 15 ECTS credits Author & title, publishing house, year, ISBN Ca price B, L, (*) Pages to be read Good to have: A candinavian/European flora with common plants. (B) Faegri, K. & Iversen, J. 1989: Textbook of pollen analysis. 4th edition (revised by Faegri, K. Kaland, P.E.,Krzyw

https://www.geologi.lu.se/sites/geologi.lu.se/files/geon02_litteratur_2015-08-26.pdf - 2026-07-20

Letter of Intent Preamble Whereas the potential participants Lund University , with address P.O. Box 117, SE-221 00 Lund, Sweden, and [organisation] , with address [address], (hereinafter the “Parties”) intend to collaborate in the project [title of project] (hereinafter the “Project”). The Parties agree upon the following: PREPARATION OF THE PROJECT Each Party undertakes to make any reasonably ne

https://www.medarbetarwebben.lu.se/sites/medarbetarwebben.lu.se/files/letter_of_intent_lund_university_-template_2015-10-26.docx - 2026-07-20