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Targeting TUBG1 in RB1-negative tumors

The disruption of microtubule dynamics serves as a pivotal strategy for eliminating tumor cells, despite its accompanying toxicities affecting non-tumor cells. This study investigates the potential of selectively targeting γ-tubulin1 (TUBG1) as a therapeutic strategy in cancer treatment. By elucidating the TUBG1-E2F1-retinoblastoma protein (RB1) network, we introduce a novel compound, 4-(6-((3-Met

Measurement of deeply virtual Compton scattering at HERA

A measurement is presented of elastic deeply virtual Compton scattering gamma* p -> gamma p made using e(+) p collision data corresponding to a luminosity of 46.5 pb(-1), taken with the H1 detector at HERA. The cross section is measured as a function of the photon virtuality, Q(2), the invariant mass of the gamma* p system, W, and for the first time, differentially in the squared momentum transfer

Search for bosonic stop decays in R-parity violating supersymmetry in e(+)p collisions at HERA

A search for scalar top quarks in R-parity violating supersymmetry is performed in e(+)p collisions at HERA using the H1 detector. The data, taken at roots = 319 GeV and 301 GeV, correspond to an integrated luminosity of 106 pb(-1). The resonant production of scalar top quarks t in positron quark fusion via an R-parity violating Yukawa coupling lambda' is considered with the subsequent bosonic sto

Solar Activity Changes at the End of the Last Ice Age - Influences on Climate and Applications for Dating

Popular Abstract in Swedish Under sin livstid har Jorden genomlevt upprepade naturliga klimatförändringar. Genom att undersöka dessa klimatförändringar över tid och rum så kan vi öka vår förståelse för underliggande dynamik och mekanismer och därmed bättre förstå klimatsystemet. Två grundläggande förutsättningar för sådana undersökningar är trovärdiga rekonstruktioner av tidigare variationer i styThroughout its history Earth experienced a variety of natural climate changes. By investigating their spatial and temporal evolution we can increase the understanding of the mechanisms and dynamics underlying natural climate change and improve our general comprehension of the climate system. Prerequisites of these investigations are reliable reconstructions of past forcing variations as well as so

Perceived discrimination and refraining from seeking physician's care in Sweden : an intersectional analysis of individual heterogeneity and discriminatory accuracy (AIHDA)

BACKGROUND: Discrimination may further impede access to medical care for individuals in socially disadvantaged positions. Sociodemographic information and perceived discrimination intersect and define multiple contexts or strata that condition the risk of refraining from seeking physician's care. By applying analysis of individual heterogeneity and discriminatory accuracy (AIHDA) we aimed to impro

Remote sensing phenology at European northern latitudes - From ground spectral towers to satellites

Popular Abstract in Swedish Växters fenologi påverkar ekosystemens funktion och tjänster, och återkopplar till klimatet genom att påverka utbytet av kol, vatten och energi mellan atmosfär och ekosystem. Under de senaste decennierna har växternas fenologi studerats i allt större omfattning, men fortfarande är osäkerheten stor och enighet saknas om klimatets inverkan på fenologi och förändringar övePlant phenology exerts major influences on carbon, water, and energy exchanges between atmosphere and ecosystems, provides feedbacks to climate, and affects ecosystem functioning and services. Great efforts have been spent in studying plant phenology over the past decades, but there are still large uncertainties and disputations in phenology estimation, trends, and its climate sensitivities. This

From Medication to Education - People with autism in adult psychiatry

This dissertation concerns the field of applied psychiatry and focuses on the problems that are associated with the care and treatment of adult patients with autism spectrum disorders. The conditions that are described are valid for Swedish psychiatry and cannot be directly generalized to conditions outside of the country.

First measurement of charged current cross sections at HERA with longitudinally polarised positrons

Data taken with positrons of different longitudinal polarisation states in collision with unpolarised protons at HERA are used to measure the total cross sections of the charged current process, e(+) p -> nu X, for negative four-momentum transfer squared Q(2) > 400 GeV2 and inelasticity gamma < 0.9. Together with the corresponding cross section obtained from the previously published unpolarised da

Measurement of charm and beauty photoproduction at HERA using D*mu correlations

A measurement of charm and beauty photoproduction at the electron proton collider HERA is presented based on the simultaneous detection of a D*(+/-) meson and a muon. The correlation between the D* meson and the muon serves to separate the charm and beauty contributions and the analysis provides comparable sensitivity to both. The total and differential experimental cross sections are compared to

Åldrande hos personer med intellektuell funktionsnedsättning - ur ledares perspektiv

Det har skett en markant ökning av medellivslängden för personer med intellektuell funktions-nedsättning under de senaste decennierna och allt fler uppnår pensionsåldern och hög ålder. Ökningen är ett direkt resultat av medicinska och sociala framsteg. Samtidigt är det en grupp som har svårigheter att uttrycka sina behov och där forskning visat att deras åldrande ter sig annorlunda än för befolkni

The added value of a mobile application of Community Case Management on referral, re-consultation and hospitalization rates of children aged under 5 years in two districts in Northern Malawi : Study protocol for a pragmatic, stepped-wedge cluster-randomized controlled trial

Background: There is evidence to suggest that frontline community health workers in Malawi are under-referring children to higher-level facilities. Integrating a digitized version of paper-based methods of Community Case Management (CCM) could strengthen delivery, increasing urgent referral rates and preventing unnecessary re-consultations and hospital admissions. This trial aims to evaluate the a

Sedation in specialized palliative care : A cross-sectional study

BACKGROUND: Palliative sedation is used to relieve refractory symptoms and is part of clinical practice in Sweden. Yet we do not know how frequently this practice occurs, how decision-making takes place, or even which medications are preferentially used.OBJECTIVES: To understand the current practice of palliative sedation in Sweden.METHODS: We conducted a retrospective cross-sectional medical reco

Stem cells expanded from the human embryonic hindbrain stably retain regional specification and high neurogenic potency

Stem cell lines that faithfully maintain the regional identity and developmental potency of progenitors in the human brain would create new opportunities in developmental neurobiology and provide a resource for generating specialized human neurons. However, to date, neural progenitor cultures derived from the human brain have either been short-lived or exhibit restricted, predominantly glial, diff

Manifest for en battre ljudmiljo

Manifest för en bättre ljudmiljö A 5 version II.indd manifest för en bättre ljudmiljö Manifestet antaget av Kungl. Musikaliska Akademiens styrelse den 8 februari 1995 Skrifter från Lyssnande Lund Ljudmiljöcentrum vid Lunds universitet MANIFEST Lunds universitet 2006 för en bättre l judmil jö manifest för en bättre ljudmiljö Manifestet antaget av Kungl. Musikaliska Akademiens styrelse den 8 februar

https://www.lmc.lu.se/sites/lmc.lu.se/files/2021-08/manifest_for_en_battre_ljudmiljo.pdf - 2026-06-03

Kommers-guide-fornyad-konkurrensutsattning

Kommers-guide: Förnyad konkurrensutsättning 1 Senast uppdaterad: 2026-05-25 Innehåll Innehåll ....................................................................................................................................... 1 Om guiden .................................................................................................................................. 3 1 Förutsättningar .......

https://www.medarbetarwebben.lu.se/sites/medarbetarwebben.lu.se/files/2026-05/Kommers-guide-fornyad-konkurrensutsattning%20.pdf - 2026-06-03

Annonspliktig Upphandling Under Tröskelvärdet upphandlingsdokument v220609

Mall - upphandlingsdokument vid förenklad upphandling InstAvdEnhet HandläggareTitel 2 Upphandlingsdokument, annonspliktig upphandling under tröskelvärdet XXX Adressat DOKUMENTNAMN Diarienummer 1 Datum Administrativa föreskrifter Lunds universitet inbjuder till anbudsgivning rörande ***XXX***. I detta upphandlingsdokument finns alla nödvändiga uppgifter, krav och villkor för att lämna anbud. Vi emo

https://www.medarbetarwebben.lu.se/sites/medarbetarwebben.lu.se/files/2022-06/Annonspliktig%20upphandling%20under%20tr%C3%B6skelv%C3%A4rdet_upphandlingsdokument_v220609.docx - 2026-06-03

Socialtjänstens stödgrupper för barn : En lätt tillgänglig insats?

Stödgrupper för barn som växer upp i familjer med psykisk ohälsa, skadligt bruk/beroende eller våld är en insats som erbjuds av socialtjänsten i många kommuner. Trots att stödgrupper ges på frivilliga grunder utan biståndsprövning, dvs ”lätt tillgängligt” (Prop.2024/25:89), är rekryteringen av barn en utmaning. Denna licentiatuppsats fördjupar kunskapen om de förhållanden och överväganden som påveIn Sweden, preventive support groups for children exposed to domestic violence, substance abuse or mental illness in the home are provided by child welfare services (CWS). Support groups for children are often accessible without assessment, available for families to access at their own request, without formal referral or opening a case file which is assumed to lower the threshold. A current approa

Summary of the International Society for Heart and Lung Transplantation (ISHLT) Consensus Conference on Graft Dysfunction within the First 72 hours after Heart Transplantation : A 10-year Update

Primary graft dysfunction (PGD), defined as ventricular dysfunction occurring within 24 hours after heart transplantation (HTx) in the absence of identifiable secondary causes, remains a major contributor to early post-transplant mortality. Over the past decade, there has been a growing understanding of the burden of PGD, the clinical relevance of PGD classification and severity grading, and effor