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Context Adjuvant imatinib administered for 12 months after surgery has improved recurrence-free survival (RFS) of patients with operable gastrointestinal stromal tumor (GIST) compared with placebo. Objective To investigate the role of imatinib administration duration as adjuvant treatment of patients who have a high estimated risk for GIST recurrence after surgery. Design, Setting, and Patients Pa
The classical pathway of complement is crucial to the immune system, but it also contributes to inflammatory diseases when dys-regulated. Binding of the C1 complex to ligands activates the pathway by inducing autoactivation of associated C1r, after which C1r activates C1s. C1s cleaves complement component C4 and then C2 to cause full activation of the system. The interaction between C1s and C4 inv
We present a very simple polymer model of polyethylene glycols/oxides in water that can be used in combination with Molecular Dynamics or Monte Carlo simulations to accurately reproduce the equation of state and radii of gyrations across several orders of magnitude, in terms of osmotic pressure and polymer length. This is of importance for example in osmotic stress experiments, with the aim to acc
A method is described for quantification of the beef tenderness marker, calpastatin, in meat samples by amperometric detection. Using a novel bovine recombinant partial calpastatin protein as standard antigen a low detection limit of 0.2 ng/mL was achieved. The influence of the complex matrix was minimised by heat pretreatment and dilution of the samples prior to detection of calpastatin. The rela
ABSTRACT: Simultaneous saccharification and fermentation (SSF) is one process option for production of ethanol from lignocellulose. The principal benefits of performing the enzymatic hydrolysis together with the fermentation, instead of in a separate step after the hydrolysis, are the reduced end-product inhibition of the enzymatic hydrolysis, and the reduced investment costs. The principal drawba
Accurately reconstructing the rate of movement and extent of eolian dunes over thousands of years is a challenging endeavor. In this paper, we refine the methodology for utilizing lakes and bogs downwind of dune fields as precise recorders of past eolian activity. Sediment cores from two Allegan County lakes and one bog associated with dunes were studied to evaluate the importance of the various s
Protein glycosylation has significant effects on the structure and function of proteins. The efficient separation and enrichment of glycoproteins from complex biological samples is one key aspect and represents a major bottleneck of glycoproteome research. In this paper, we have explored pH multimodal hydrophobic interaction chromatography to separate glycosylated from non-glycosylated forms of pr
Background and purpose - Outcome measurement has been shown to improve performance in several fields of healthcare. This understanding has driven a growing interest in value-based healthcare, where value is defined as outcomes achieved per money spent. While low back pain (LBP) constitutes an enormous burden of disease, no universal set of metrics has yet been accepted to measure and compare outco
Background: Dental caries is unevenly distributed within populations with a higher burden in low socio-economy groups. Several attempts have been made to allocate resources to those that need them the most; there is a need for convenient approaches to population-based monitoring of caries risk over time. The aim of this study was to develop the geo-map concept, addressing time trends in caries ris
This paper makes a plea for the construction of a common agenda for higher education and science, technology and innovation (STI) policy research. The public higher education and research sector in all countries is currently in the grip of several challenges arising from increased accountability, internationalization and in some cases dwindling resources. Even as the sector is struggling to come t
Abstract in UndeterminedAn efficient technique is introduced to reduce mutual coupling between two closely spaced PIFAs for MIMO mobile terminals. The proposed mutual coupling reduction method is based on a T-shape slot impedance transformer and can be applied to both single-band and dual-band PIFAs. For the proposed single-band dual PIFAs, the 10 dB impedance bandwidth covers the 2.4 GHz WLAN ban
Background Leaf-cutting ants live in symbiosis with a fungus that they rear for food by providing it with live plant material. Until recently the fungus' main inferred function was to make otherwise inaccessible cell wall degradation products available to the ants, but new studies have shed doubt on this idea. To provide evidence for the cell wall degrading capacity of the attine ant symbiont, we
We present a flexible and compact experimental setup that combines an in vacuum liquid jet with an x-ray emission spectrometer to enable static and femtosecond time-resolved resonant inelastic soft x-ray scattering (RIXS) measurements from liquids at free electron laser (FEL) light sources. We demonstrate the feasibility of this type of experiments with the measurements performed at the Linac Cohe
The purpose of this article is to present and discuss the development of a system for assessing and improving healthcare organisations. The system components comprise (1) a framework or model for assessing, measuring, diagnosing and improving healthcare organisations, (2) a simple methodology for data collection, data analysis and prioritising improvement areas and (3) an index named ILL (innovati
The world is facing of a number of great challenges as the population is growing and living habits are getting more resource demanding. At the same time as food security has to be assured, growth in biofuel and meat production pose a risk for increasing land use conflicts and negative environmental consequences. In this report production of food, feed and biofuels are discussed from a land use pe
This thesis examines how sustainability is prioritised politically and integrated in the Danish municipal primary and lower secondary education. It consults representatives from the Ministry of Education, the unicipality of Copenhagen and ten lower secondary education teachers about their perceptions of sustainability and education and their experiences with integration of sustainability education
Adipic acid is considered as the most valuable dicarboxylic acid with industrial use; however, its production is heavily petroleum-based. This non-natural metabolite can be produced de novo through different metabolic pathways, one of which is the alpha-ketoacid elongation pathway. This investigation revolved around the study of the enzyme that catalyses the first +1C elongation reaction of the pa
This study has sought to propose didactical approaches to find a balance between the teaching of classic and contemporary literature in the Swedish EFL classroom by exploring and comparing the attitudes of Swedish upper secondary school teachers and students towards both forms of literature. The study was conducted through two quantitative questionnaires, one researching the attitudes of 44 EFL st
