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Background During the last 15 years, high-dose chemotherapy with autologous hematopoietic stem cell transplantation (HSCT) has globally been performed for severe multiple sclerosis (MS). Most patients have been in progressive phase with long disease duration. As a rule, treatment effect has been minor or moderate. Patients Since 2004, we have performed HSCT in nine young patients with "malignant"
Asymmetrical flow field-flow fractionation (AsFIFFF) in combination with multi-angle light scattering (MALS) was applied to cationic potato amylopectin (CPAP) to investigate how molar mass, root-mean-square (r.m.s.) radius and shape was influenced by different conditions of jet-cooking. The effect of different jet-cooking temperatures in the range 110 degrees C - 140 degrees C was studied in an ex
Background & Aims: Preterm birth and formula feeding are key risk factors associated with necrotizing enterocolitis (NEC) in infants, but little is known about intestinal conditions that predispose to disease. Thus, structural, functional, and microbiologic indices were used to investigate the etiology of spontaneous NEC development in preterm pigs. Methods : Piglets were delivered by cesarean
Low-energy buildings are nowadays often used in common speech, for selling or promotion – everything has to be ”low energy”. But how do you know if your house is a low energy building? And how do the manufacturers of the building components know? Is there an official definition, what technical criteria do these buildings have to fulfill? The growing of low-energy buildings causes a demand of compl
The now Swedish province of Scania has had a long history of violence and unrest, with several wars being fought on Scanian soil. Such tumultuous times must have impacted the common people and their living conditions, yet bioarchaeological research is lacking for post-medieval Scania and much of Sweden. By analysing a skeletal material from a 16-18th century semi-urban cemetery in Ängelholm, for w
Helicobacter pylori is an important pathogen inhabiting the human stomach. H. pylori binds plasminogen, a 90 kDa glycoprotein secreted by liver cells, and utilizes it for enhancing virulence. Surface receptors on the bacteria recognize plasminogen that is then activated into plasmin by host factors. The active plasmin can degrade a range of host proteins including proteins of the extracellular mat
Building interaction prototypes for ubiquitous computing is inherently difficult, since it involves a number of different devices and systems. Prototyping is an important step in developing and evaluating interaction concepts. The ideal prototyping methodology should offer high fidelity at a relatively low cost. This thesis describes the development of interaction concepts for controlling consume
An estimated 6% of human greenhouse gas emissions are the result of enteric methane production by cows. Asparagopsis taxiformis, a semi-tropical alga, is one solution. Supplementation of this alga to cows at a small percentage of their daily intake has reduced methane emissions by over 98% in trials. This success has led to multiple commercialization attempts globally, although no Asparagopsis tax
Homework is widely used in most schools across the world to complement classroom teaching, increase knowledge retention, and foster good study habits. The research on the effect of homework assignment on student achievement is, however, inconclusive with earlier research indicating a positive relationship and newer studies giving a more nuanced picture. This thesis uses data from the 2019 wave of
This comparative document analysis looks at the governmentality of the Finnish labor market policies (LMP’s). This study compares Sipilä’s and Marin’s government programs to see if there are differences. The focus is on depicting neoliberalization and power relations in the policies while investigating the framing of unemployment. The theoretical framework consists of the theory of neoliberal turn
The purpose of this study is to investigate how women with an ADHD diagnosis, who were diagnosed in the ages between 12-17, see their own experiences and identities in relation to role expectations of females. The ambition is to bring light to the stories of women, who have been in the shadow of the stereotypical ADHD man in society as well as in studies. The method chosen for empirical material i
Omkring 20 procent av alla människor världen över (1,5 miljarder) har inte ett officiellt, juridiskt dokument som bevis på sin identitet. Detta påverkar till exempel deras rösträtt, att öppna ett bankkonto, få formell anställning eller söka juridisk ersättning. Deras brist på bevis på juridisk existens exkluderar dem alltså från att delta på samtliga nivåer i samhället. Denna omfattande problematiAround 20% of all people worldwide (1.5 billion) do not have an official and legally recognized document as proof of their identity. This affect, for example, their right to vote, to open a bank account, obtain formal employment or seek legal compensation. In other words, their lack of proof for their legal existence excludes them from participating in society on all various levels. This was ackno
Lactobacillus reuteri is known as probiotics with health benefits. Freeze-drying is frequently used to preserve probiotics and keep them alive. However, freeze-drying through freezing and drying might cause some damages to the probiotic’s cells. Formulation by protective agents including cryoprotectants and lyoprotectants prior to freeze-drying can prevent and reduce these damages. In this study,
Climate change is affecting all regions of the globe, causing a shift of temperature distributions. As species try to track their optimal thermal conditions, they are also potentially met with new photic environments. Photoperiod is the main cue for synchronizing migratory birds' circannual rhythms, affecting both their physiology and migration. Thus, their ability to incorporate and adjust to
Climate change is an issue affecting societies worldwide. As temperatures, precipitation patterns, and sea levels change, our buildings and properties are in danger. Therefore, it is crucial for real estate companies to adapt their properties to the effects of climate change as they will be impacted. To help companies make environmentally sustainable economic activities, the European Union has imp
High-grade serous ovarian cancer (HGSOC) is the most lethal subtype of ovarian cancer and remains a major clinical challenge due to frequent late diagnosis and limited treatment options. This study investigates the therapeutic potential of targeting the oncogenic interaction between metadherin (MTDH) and staphylococcal nuclease domain-containing 1 (SND1) which are proteins known to promote tumor p
How can the low representation of women in politics in Bosnia-Herzegovina be understood and what can a different approach add to already existing approaches to make Bosnia-Herzegovina more gender equal in terms of political representation of the genders? There has been established a Gender Equality Law that demands a 40% gender quota of political representation, but the gender representation has o
