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The identification of serum biomarkers for the diagnosis of inflammatory bowel diseases able to reduce the need for invasive tests represents a major goal in their therapy and follow-up. We report here a methodological approach for the evaluation of specific changes in the serum peptides abundance in healthy (H) and Crohn's disease (CD) subjects, based on a label-free LC ESI/Q-TOF differential mas
The semiconductor technology development makes it possible to fabricate increasingly advanced integrated circuits (ICs). However, because of imperfections at manufacturing, each individual IC must be tested. A major problem at IC manufacturing test is the increasing test data volume as it leads to high automatic test equipment (ATE) memory requirement, long test application time and low throughput
An efficient method is proposed for the evaluation of the absorption and the transport scattering coefficients from a time-resolved reflectance or transmittance distribution. The procedure is based on a library of Monte Carlo simulations and is fast enough to be used in a nonlinear fitting algorithm. Tests performed against both Monte Carlo simulations and experimental measurements on tissue phant
A de novo alpha-synuclein A53T (p.Ala53 Th; c.209G > A) mutation has been identified in a Swedish family with autosomal dominant Parkinson's disease (PD). Two affected individuals had early-onset (before 31 and 40 years), severe levodopa-responsive PD with prominent dysphasia, dysarthria, and cognitive decline. Longitudinal clinical follow-up, EEG, SPECT and CSF biomarker examinations suggested an
Objective: The European System for Cardiac Operative Risk Evaluation (EuroSCORE) is used to identify patients at high risk for aortic valve replacement (AVR) in whom alternative procedures, such as trans-catheter aortic valve implantation (TAVI), may be appropriate. The aim of the present study was to calibrate and validate the EuroSCORE for different cardiac surgery procedures to improve patient
Scand J Caring Sci; 2011 Online self-help tools for the relatives of persons with depression - a feasibility study Background: The Internet's potential as health care tool should be explored. Aim: One objective was to determine the feasibility of constructing a digitally based tool through an iterative design process in cooperation with potential users. The tool's purpose is to alleviate hardships
In dense passive radio frequency identification (RFID) systems, code division multiple access (CDMA) techniques can be used to alleviate severe collisions and thus enhance the system performance. However, conventional CDMA techniques are challenging to implement, especially for passive tags due to cost and power constraints. In this paper, we design a CDMA-based multi-reader passive ultra high fre
We investigated possible motivations for sound symbolism in spatial demonstratives within 101 areally and genetically diverse languages. Six different predictions were formulated on the basis of factors such as (a) semiotic ground (iconic, indexical or combined), (b) speaker-centered, hearer-centered or both and (c) applicable to vowels, consonants or both. Each one of these six predictions result
A delay in surgery due to laboratory abnormalities may increase mortality in patients with hip fracture. In order to optimize the logistics for urgent surgery in patients with hip fractures and anti-vitamin K treatment, individualized doses of a Prothrombin Concentrate were guided by a bedside whole blood prothrombin time test. Thirty patients with emergency hip fracture and preoperative anti-vit
Summary: Polymethylmethacrylate, as a widely used material for vertebroplasty, has several drawbacks such as heat development and high allergenic potential. In order to avoid these drawbacks ceramic cement materials have been developed. The purpose of this study was to evaluate a new biointegrative material for vertebroplasty in osteoporotic vertebral fractures regarding pain relief, safety aspect
It is well known that user proximity introduces absorption and impedance mismatch losses that severely degrade multiple-input multiple-output (MIMO) performance of handset antennas. In this work, we experimentally verified the potential of adaptive impedance matching (AIM) to mitigate user interaction effects and identified the main AIM gain mechanism in realistic systems. A practical setup includ
Soft-input/soft-output symbol decoding plays a significant role in iterative decoding. We propose a simple optimal soft-input/soft-output symbol decoding algorithm for linear block codes which requires one forward recursion using a trellis. For many codes the decoding complexity is lower than previous methods, such as the algorithm by Bahl et al. (1974), and the decrease is shown at its most when
Dopamine (DA) neurons derived from human embryonic stem cells (hESCs) are potentially valuable in drug screening and as a possible source of donor tissue for transplantation in Parkinson's disease. However, existing culture protocols that promote the differentiation of DA neurons from hESCs are complex, involving multiple steps and having unreliable results between cultures. Here we report a simpl
Given an electronic wave function, generated by the MCHF program (LS format) or the MCHF_CI program (LSJ format), this program computes the hyperfine interaction constants, A(J) and B(J). In strong experimental magnetic fields, the splitting is also affected by the off-diagonal hyperfine constants A(J,J-1), B(J,J-1), and B(J,J-2) and these are computed as well, depending on the input data.
