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Protein interactions are important in understanding various protein relevant cellular and technological processes.This is a challenging task due to the intrinsically irregular shape and inhomogeneous surface distribution of neutral, charged, hydrophobic amino acid residues. This results inmore or less anisotropic interactions depending on external parameters such assalt and pH. However, a deeper uProtein interactions are important in understanding various protein relevant cellular and technological processes.This is a challenging task due to the intrinsically irregular shape and inhomogeneous surface distribution of neutral, charged, hydrophobic amino acid residues. This results inmore or less anisotropic interactions depending on external parameters such assalt and pH. However, a deeper u

The overall aim was to investigate informal caregivers providing care for older persons with dementia (≥ 65 years of age) in eight European countries. Focus was on their experiences of formal care, access to support and factors that were associated with caregivers’ psychological well-being and burden. Caregivers’ experiences of formal care were investigated in a qualitative study with four focus g

Despite the benefits of currently available preventative and therapeutic interventions, atherosclerotic vascular disease continues to be a major cause of morbidity and mortality in much of the Western World. This emphasize,,, the need for additional preventive and therapeutic interventions exploiting new targets to compliment and augment the results of LDL lowering and other current strategies. On

The ubiquitin E3 ligase Cbl has been shown to negatively regulate tyrosine kinase receptors, including the stem cell factor receptor/c-Kit. Impaired recruitment of Cbl to c-Kit results in a deregulated positive signalling that eventually can contribute to carcinogenesis. Here, we present results showing that Cbl is activated by the SFKs (Src family kinases) and recruited to c-Kit in order to trigg

This book is about packaging design for sustainable development, the kind of design that can make our lives friendlier, our planet greener and our businesses richer. It is necessary and obvious that we need to move towards a more sustainable society, as we see more pollution in our oceans, more waste in our streets, more landfills and the tremendous waste of essential resources such as food on our

Background: To become a parent of a child who is born small for gestational age can lead to challenges in addition to the newly acquired parenting role. There is currently a lack of knowledge regarding parents' experiences of having a child born small for gestational age. Purpose: The purpose of this study was to describe the experience of becoming a parent of a child small for gestational age Des

This dissertation studies the labor market development of fourteen Western European countries during the years 1970-90, focusing on the relatively low Swedish unemployment. The variation in unemployment over time and between countries has proved difficult to explain with the most influential theoretical models, which are usually categorized as New-keynesian and Post-keynesian respectively. The dis

This chapter examines if identity is as important as is often claimed, and as a consequence, when and why concerns of identity are triggered in working life, and we do so through a constructionist identity perspective. In the chapter, we argue that many people do not necessarily engage with their identities most of the time and explore why they do in certain kinds of jobs and in particular situati

BACKGROUND/AIMS: The aim of this study was to develop a risk model for intraoperative complication (IC) during cataract surgery, defined as posterior capsule rupture and/or zonular dehiscence, and to include previous intravitreal therapy (pIVT) in the model.METHODS: This retrospective register-based study covered patients reported to the Swedish National Cataract Register (SNCR) between 1 January

HCV infection is a major risk factor for liver cancer and liver transplantation worldwide. Overstimulation of host lipid metabolism in the liver by HCV-encoded proteins during viral infection creates a favorable environment for virus propagation and pathogenesis. In this study, we hypothesize that targeting cellular enzymes acting as master regulators of lipid homeostasis could represent a powerfu

Modern-day work is a central reason for unsustainability, and its transformation is therefore key for sustainability. A recurring manifestation of this issue is the ‘jobs-environment-dilemma’, a trade-off arising due to severe ecological impacts caused by work on the one hand, and the structural constitution of modern industrial society as work-centred and work-dependent on the other. We draw on i

Background: Screening across a multitude of normal and malignant tissues revealed an enhanced expression of lymphocyte antigen 6 superfamily member D (LY6D) in squamous epithelium and urothelium, as well as in malignancies derived therefrom. The aim of this study was to further delineate the protein expression of LY6D in urothelial bladder cancer, with particular attention to its relationship with

Family history of depression is an important risk factor for depression. The aim of this study was to examine whether the effect of family history of depression is confounded by individual and familial socioeconomic factors (i.e., country of origin, educational attainment, family income and mobility) and neighborhood environmental factors (i.e., neighborhood deprivation and neighborhood social cap

Purpose The purpose of this thesis is to study if and how institutional investors have any impact on shareholder value and operating performance on the Swedish market. The tested explanatory variables are institutional investors grouped in different ways depending on their attributes, firm size, board size and board structure, leverage, firm size, share turnover and stock volatility. Theoretical

The thesis deals with which legal basis seems appropriate to use when the purpose of the data controller is to carry out direct marketing. When processing personal data, the Controller must comply with the principles set out in Article 5 of the GDPR. One of the principles, the Principe of Lawfulness, requires the Processing to be supported on a legal basis in Article 6 of the GDPR. It is stated th