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The mechanisms underlying M. fortuitum-induced pathogenesis remains elusive. Using headkidney macrophages (HKM) from Clarias gariepinus, we report that TLR-2-mediated internalization of M. fortuitum is imperative to the induction of pathogenic effects. Inhibiting TLR-2 signalling alleviated HKM apoptosis, thereby favouring bacterial survival. Additionally, TLR-2-mediated cytosolic calcium (Ca2+)c
Associate professor Contact details Email: maria [dot] soderberg [at] soch [dot] lu [dot] seOrganisation School of Social Work Service point: 28 WebpageMaria Söderbergs profile in Lund University research portalOther affiliations Associate professor Ageing and Eldercare Associate professor Professions and OrganisationResearchMy research is mainly about social work with a focus on older people. For
https://www.soch.lu.se/en/maria-soderberg - 2026-06-24
In plants, 14-3-3 proteins are key regulators of primary metabolism and membrane transport. Although the current dogma states that 14-3-3 isoforms are not very specific with regard to target proteins, recent data suggest that the specificity may be high. Therefore, identification and characterization of all 14-3-3 (GF14) isoforms in the model plant Arabidopsis are important. Using the information
To estimate incremental costs for patients with psoriasis/psoriatic arthritis (PsO/PsA) compared to population-based referents free from PsO/PsA and estimate costs attributable specifically to PsO/PsA.
The cell cycle regulating protein p27(Kip1) (p27) has dual roles by acting as both a cdk-inhibitor and as an assembly factor for different cdk-complexes. Loss of p27 has been linked to malignant features in tumours, however the exact role of p27 deregulation in breast cancer regarding prognostic and treatment predictive information has not been fully clarified. We have evaluated p27 expression in
BACKGROUND: The increasing number of survivors after childhood cancer requires characterization of the late complications of these diseases and their treatment. We examined a large number of possible socio-economic late effects following treatment for acute lymphoblastic leukemia (ALL) in order to identify factors leading to a poor outcome. PROCEDURE: All individuals who had been diagnosed with AL
Purpose: To assess the associations of meniscal tears, knee malalignment, cartilage damage, knee effusion, and body mass index with meniscal extrusion. Materials and Methods: The Multicenter Osteoarthritis study is an observational study of individuals who have or are at risk for knee osteoarthritis (OA). The HIPAA-compliant protocol was approved by the institutional review boards of all particip
Størling and colleagues hypothesise in this issue (Diabetologia DOI: 10.1007/s00125-013-3045-3 ) that post-translational modification (PTM) of autoantigens might create tissue-specific neo-epitopes that could trigger type 1 diabetes. Data on PTM of islet autoantigens are scarce and readers should not believe that the PTM hypothesis is supported by strong experimental evidence. The proposed genetic
The plasma levels of cystatin C, β2-microglobulin, beta-trace protein, retinol binding protein (RBP) and creatinine were determined in plasma samples from 111 randomly selected patients with eGFRcystatin C ≤ 60% of eGFRcreatinine and from 55 control patients with 0.9eGFRcreatinine ≤ eGFRcystatin C ≤ 1.1eGFRcreatinine (eGFRcystatin C ≈ eGFRcreatinine). The concentration ratios of cystatin C/creatin
Screening for abdominal aortic aneurysm (AAA) among 65 year old men has been proven cost-effective, but nowadays is conducted partly under new conditions. The prevalence of AAA has decreased, and endovascular aneurysm repair (EVAR) has become the predominant surgical method for AAA repair in many centers. At the Malmö Vascular Center pharmacological secondary prevention with statins, antiplatelet
The conceptual shift in expectations of wireless users from voice towards multimedia, from availability towards acceptable quality, and from stand-alone towards group-oriented computing has a big impact on the needs of today's networks in terms of mobility, quality of service (QoS) support, and multicasting. Ad hoc networks can provide users with these features. However, it is necessary to develop
Popular Abstract in Swedish Att mäta kroppsställningar och rörelser under arbete Belastningsskador är vanliga och medför höga kostnader, både för de drabbade och för samhället. Kvinnor som arbetar med repetitivt arbete, t.ex. monteringsarbete och livsmedelshantering (fiskberedning och kycklingslakt), drabbas ofta, särskilt i nacke, axlar, armar och händer. De åtgärder som genomförts på arbetsplatWork-related musculoskeletal disorders of the neck and upper limb are a major problem. Women in repetitive manual work is one large affected group. Preventive actions are hampered by the lack of knowledge regarding quantitative exposure-response relations for physical workload. The present work shows, that available electrogoniometers are, with a sampling frequency of 20 Hz, feasible for measurin
Popular Abstract in English Experiments, such as the Large Hadron Collider (LHC) in CERN, Switzerland, collide particles together at high energies, in the hope of probing the fundamental constituents and forces of nature. On the theoretical side, the Standard Model (SM) is currently the best description we have. It is a theory that encompasses the strong, weak and electromagnetic forces, although This thesis involves phenomenological models for describing high energy particle collisions. One class of these models, multiparton interactions (MPI), deals with the fact that when colliding two hadrons, it is possible for more than one pair of their constituents to interact. The other deals with parton showers, which are used to fill enhanced regions of phase space and give fully exclusive final
I bokens första studie, "Samhällsbyggarnas tv-undervisning. Estetik och ideologi i utbildningsprogram för televisionen" författad av Ann-Kristin Wallengren, ställs frågan om hur ett programs form och estetik är kopplat till samtidens samhällsbild och ideologier. Genom analyser av ett antal samhällskunskapsprogram för skolbarn visas hur utbildningsprogrammen från 1960-talet och framåt har förändrat
