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types of B-cell lymphomas. However, the role of MYC in mantle cell lymphoma (MCL), a clinically diverse and incurable disease, needs to be further elucidated. The aim of this study is to evaluate MYC mRNA deregulation and explore the mechanism behind PLK-1 induced cell death, as a target for MYC-driven MCL. To achieve this, RNAscope® is used to detect and quantify MYC mRNA expression in a populati
Examensarbetets syfte är att undersöka hur delar av ett byggföretags kvalitetsarbete är uppbyggt och anpassat efter verksamheten. Författarna har tagit del av fallföretagets interna undersökning som tyder på en nedåtgående användning av företagets ledningssystem. Författarnas mål är att identifiera brister för att sedan ge förslag på förbättrings-möjligheter. Examensarbetet har utförts i form av
Reception – hospitality and hostilityMarcus Knutagård and Arne KristiansenSchool of Social Work, Lund UniversityThe aim of this paper is to analyse the practice of reception of newly arrived migrants. The paper is part of an ongoing project Scanian homes: Reception, settlement or rejection – homelessness policies and strategies for refugee settlement. The aim of the project is to investigate the p
OBJECTIVE: The mechanisms underlying the association between diabetes and inner ear dysfunction are not known yet. The aim of the present study is to evaluate the impact of obesity/insulin resistance on inner ear fluid homeostasis in vivo, and to investigate whether the organ of Corti could be a target tissue for insulin signaling using auditory House Ear Institute-Organ of Corti 1 (HEI-OC1) cells
Den svenska partipolitiken kännetecknades länge av en tydlig klassdiskurs, och ansågs vara undantaget för nedgången i den klassbaserade röstningen. Under de senaste decennierna har däremot även Sverige genomgått förändringar i den klassbaserade röstningen där arbetarklassens väljare alltmer förflyttats från socialdemokratin till högernationalistiska partier. Följande undersökning avser därför att
The European Union’s depoliticized understanding of democracy has consistently been a contested subject within political science. Many studies have focused on the overarching electoral system and the European Commission. Few have delved deeper into the constituent units within the actors. Using Oleart & Theuns’ (2023) hypothesis as a point of departure, we aim to uncover if the Commission’s Di
The digital games industry is one of the fastest growing branches in the creative sector in Sweden: In the last three years the proportion of employees has increased with about 20 percent. Specific for this branch is that digital games companies compete in a highly globalized and digitalized market dominated by a few large corporations. It creates the backdrop for specific working conditions. Prev
BackgroundChronic pain is a highly prevalent disease, leading to high health care costs, impaired productivity, and decreased quality of life. An artificial intelligence (AI)-powered, digital tool for self-management (PaindrainerTM) has been shown to be an effective treatment in chronic pain and may have potential to reduce the burden on costs and quality of life.ObjectiveThe objective of this stu
STUDY OBJECTIVES: The aim was to evaluate nasal polyposis as a risk factor for nonadherence to continuous positive airway pressure (CPAP) treatment in patients with obstructive sleep apnea (OSA). METHODS: This was a population-based, longitudinal analysis of patients starting CPAP treatment for OSA in the Swedish quality registry Swedevox between 2010 and 2018. Data were cross-linked with national
We investigate organizational members’ crisis sensemaking and construction ofresponsibility at the peak of a corporate scandal. We focus on those organizationalmembers, who are not directly involved in the scandal but are still affected by it, as theyare questioned about their collective and moral responsibility for being members of anorganization that has engaged in wrongdoing. Our study is based
The Wilms' tumor gene 1 (WT1) is recurrently mutated in acute myeloid leukemia. Mutations and high expression of WT1 associate with a poor prognosis. In mice, WT1 cooperates with the RUNX1/RUNX1T1 (AML1/ETO) fusion gene in the induction of acute leukemia, further emphasizing a role for WT1 in leukemia development. Molecular mechanisms for WT1 are, however, incompletely understood. Here, we identif
Many automated gating algorithms for flow cytometry data are based on the concept of unimodal cell populations. However, in this article, we show that criteria previously used to make decisions on unimodality cannot adequately distinguish unimodal from bimodal densities. We show that dip and bandwidth tests for unimodality, taken from the statistics literature, can do this with consistent and low
Understanding the molecular mechanisms leading to retinal development is of great interest for both basic scientific and clinical applications. Several signaling molecules and transcription factors involved in retinal development have been isolated and analyzed; however, determining the direct impact of the loss of a specific molecule is problematic, due to difficulties in identifying the correspo
In plants, 14-3-3 proteins are key regulators of primary metabolism and membrane transport. Although the current dogma states that 14-3-3 isoforms are not very specific with regard to target proteins, recent data suggest that the specificity may be high. Therefore, identification and characterization of all 14-3-3 (GF14) isoforms in the model plant Arabidopsis are important. Using the information
Despite various ongoing international initiatives, the intensity and frequency of weather-related natural hazards is expected to continue to increase globally. Increasing our understanding of how to mitigate the consequences of such natural hazards through better detection, planning and preparedness, has constituted the overarching objective of this thesis. The thesis is based on three papers: PapDespite various ongoing international initiatives, the intensity and frequency of weather-related natural hazards is expected to continue to increase globally. Increasing our understanding of how to mitigate the consequences of such natural hazards through better detection, planning and preparedness, has constituted the overarching objective of this thesis. The thesis is based on three papers: Pap
NYTT FRÅN LUNDS UNIVERSITET Mejlutskick på svenska och engelska som vänder sig till fakultetskommunikatörer vid Lunds universitet för vidarespridning i fakultets- och institutionskanaler – Nr 11 v 12 - 2021. CORONARELATERAT Lunchföreläsningar för studenter om utmaningar med hemmastudier Studenthälsan ordnar kurser och föreläsningar under våren med fokus på hemmastudier. Ämnen som tas upp är tips,
https://www.cec.lu.se/sites/cec.lu.se/files/2021-04/LU-gemensamt%20Mejlutskick%20Nr%2011-v12-2021.pdf - 2026-07-04
