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Patients with ductal carcinoma-in-situ (DCIS) are currently not prescribed adjuvant systemic treatment after surgery and radiotherapy. Prediction of DCIS patients who would benefit from radiotherapy is warranted. Statins have been suggested to exert radio-sensitizing effects. The target for cholesterol-lowering statins is HMG-CoA reductase (HMGCR), the rate-limiting enzyme in the mevalonate pathwa
Celiac disease is associated with tissue transglutaminase autoantibodies (tTGA) in individuals carrying the HLA risk-haplotypes DQA105:01-DQB102:01 (DQ2) and/or DQA103:01-DQB103:02 (DQ8). The aim was to identify celiac disease in a HLA genotyped birth-cohort prospectively screened for celiac disease.
The SYT-SSX fusion gene has been implicated in the malignant tumor cell growth of synovial sarcoma, but the underlying molecular mechanisms are still poorly understood. Here we demonstrate that SYT-SSX is critical for the protein level of cyclin D1 in synovial sarcoma cells. Antisense oligonucleotides to SYT-SSX mRNA rapidly and drastically decreased cyclin D1 and subsequently inhibited cell growt
To estimate incremental costs for patients with psoriasis/psoriatic arthritis (PsO/PsA) compared to population-based referents free from PsO/PsA and estimate costs attributable specifically to PsO/PsA.
The cell cycle regulating protein p27(Kip1) (p27) has dual roles by acting as both a cdk-inhibitor and as an assembly factor for different cdk-complexes. Loss of p27 has been linked to malignant features in tumours, however the exact role of p27 deregulation in breast cancer regarding prognostic and treatment predictive information has not been fully clarified. We have evaluated p27 expression in
National guidelines are released regularly, and professionals are expected to adopt and implement them. However, studies dealing with mental health-care professionals' views about guidelines are sparse. The aim of the present study was to highlight mental health-care staff's views on the Swedish national guidelines for 'psychosocial interventions for schizophrenia or schizophrenia-type symptoms' a
The signal crayfish Pacifastacus leniusculus is an invasive species in Sweden, threatening the red-listed nobel crayfish Astacus astacus through spreading the crayfish plague. Time-to-event models can handle censored data on such introduced populations for which the state (successful or not) is only partially known at the last observation, but even though data on introduced populations most often
Title: “We are actually doing this for real”: Organizational identity and identification when CSR is part of the business model Seminar date: 1st of June 2020 Course: BUSN49 Degree Project in Managing People, Knowledge and Change Authors: Misha Voss Gustavsson & Olof Skäremo Supervisor: Monika Müller Key words: CSR, sustainable business model, organizational identity & organizational
types of B-cell lymphomas. However, the role of MYC in mantle cell lymphoma (MCL), a clinically diverse and incurable disease, needs to be further elucidated. The aim of this study is to evaluate MYC mRNA deregulation and explore the mechanism behind PLK-1 induced cell death, as a target for MYC-driven MCL. To achieve this, RNAscope® is used to detect and quantify MYC mRNA expression in a populati
Examensarbetets syfte är att undersöka hur delar av ett byggföretags kvalitetsarbete är uppbyggt och anpassat efter verksamheten. Författarna har tagit del av fallföretagets interna undersökning som tyder på en nedåtgående användning av företagets ledningssystem. Författarnas mål är att identifiera brister för att sedan ge förslag på förbättrings-möjligheter. Examensarbetet har utförts i form av
This study aims to evaluate whisky as an investment through two research questions: “What affects the value of whisky?” and “Should whisky be included in the optimal portfolio?”. The value of whisky is examined by constructing a hedonic regression using five hedonic attributes. Also, the convenience yield associated with whisky is examined. Secondly, the performance of whisky is evaluated by using
I detta examensarbete har en vägdagvattendamm i Lunds nordöstra stadsdel Brunnshög undersökts och modellerats. Syftet med studien var dels att ta fram en metod för att mäta sedimenteringshastigheter hos partiklar i dammen, dels att bygga upp en 3D-modell av dammen och simulera flödet samt fördelningen av suspenderade ämnen för på så sätt försöka avgöra var i dammen det lämpar sig bäst att ta ut va
Syftet med studien är undersöka och kartlägga hur konsumenters förtroende bevaras vid övergång från fysisk aktör till digital inom apoteksbranschen. Uppsatsen är som via en kvalitativ forskningsmetod via en abduktiv forskningsansats. Analys och slutsats bygger på empiri som erhållits genom datainsamling från semistrukturerade djupintervjuer. Genom analys av det empiriska materialet tillsammans med
This thesis examines a generation taking over the workforce: Generation Z. The purpose is to assess how Gen Z is motivated, how that differs cross-culturally, and ways in which management can respond to maximise job satisfaction and motivation, thereby increasing top talent. Gen Z is a strongly intrinsically motivated group of young professionals who are changing the workforce. We found subtle dif
Situationen för de många utsatta EU-medborgarna är en relativt ny fråga som saknar tidigare praxis på kommunal nivå. Det lämnas därför ett förhållandevis stort tolkningsutrymme som kan försvåra beslutsfattandet i frågan. Denna uppsats syftar till att skapa en förståelse för hur tjänstemännen har agerat i arbetet med utsatta EU-medborgares situation. För att få förståelsen studeras tjänstemannens r
