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Targeting the androgen receptor (AR) pathway prolongs survival in patients with prostate cancer, but resistance rapidly develops. Understanding this resistance is confounded by a lack of noninvasive means to assess AR activity in vivo. We report intracellular accumulation of a secreted antigen-targeted antibody (SATA) that can be used to characterize disease, guide therapy, and monitor response. A

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In the modern age of mediated visibility, media scandal is an immense risk that threatens to destroy the lives of people who have become the focus of public attention. The paper is concerned with the question of how the individual is affected by the attention when the media hype a story. Empirically, it is based upon in-depth interviews with Swedish persons who have been in the epicenter of scanda