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BACKGROUND: Elevated plasma levels of heparin-binding protein (HBP) are associated with risk of organ dysfunction and mortality in sepsis, but little is known about causality and mechanisms of action of HBP. The objective of the present study was to test the hypothesis that HBP is a key mediator of the increased endothelial permeability observed in sepsis and to test potential treatments that inhi
Infection with the human gastric pathogen Helicobacter pylori can give rise to chronic gastritis, peptic ulcer, and gastric cancer. All H. pylori strains express the surface-localized protein HpaA, a promising candidate for a vaccine against H. pylori infection. To study the physiological importance of HpaA, a mutation of the hpaA gene was introduced into a mouse-adapted H. pylori strain. To justi
The outer membrane protein A (OmpA) family contains an evolutionary conserved domain that links the outer membrane in Gram-negative bacteria to the semi-rigid peptidoglycan (PG) layer. The clinically significant pathogen Pseudomonas aeruginosa carries several OmpA family proteins (OprF, OprL, PA0833, and PA1048) that share the PG-binding domain. These proteins are important for cell morphology, me
Neurons are continuously generated from stem cells in the hippocampus and along the lateral ventricles in the adult brain. Neural stem cells can be propagated in vitro in the presence of epidermal growth factor (EGF) or fibroblast growth factor-2. We report here that amphiregulin, a growth factor related to EGF, is a mitogen for adult mouse neural stem cells in vitro and displays potency similar t
The present minireview of the place of cystatin C in clinical medicine emphasizes, and discuss the evidence, that cystatin C-based GFR-estimating equations do not require the use of vague terms like race and sex, that cystatin C-based GFR-esti mating equations are useful for both children and adults, including the elderly, that the best GFR-estimation requires simultaneous use of both cystatin C-
The increased schizophrenia risks for residents of cities with high levels of competition and for members of disadvantaged groups (for example migrants from low- and middle-income countries, people with low IQ, hearing impairments or a history of abuse) suggest that social factors are important for aetiology, Dopaminergic dysfunctioning is a key mechanism in pathogenesis. This editorial is a selec
Electric vehicles could help reduce greenhouse gas emissions and deliver a sustainable transport system. But the full life cycle of electric vehicles needs to be considered in order to avoid creating resource issues while trying to achieve the necessary climate goals.
The glymphatic system is a highly polarized cerebrospinal fluid (CSF) transport system that facilitates the clearance of neurotoxic molecules through a brain-wide network of perivascular pathways. Herein we have mapped the development of the glymphatic system in mice. Perivascular CSF transport first emerges in hippocampus in newborn mice,
Aortoenteric fistula formation is a devastating condition regardless of whether it is primary or secondary (i.e. after previous aneurysm repair) in nature. Patients present with signs and symptoms of gastrointestinal bleeding with or without signs of systemic infection and are often in a very poor clinical condition. Conventional treatment consists of extensive open surgery (extra-anatomical bypas
Terminal differentiation of mammalian erythroid progenitors involves 4-5 cell divisions and induction of many erythroid important genes followed by chromatin and nuclear condensation and enucleation. The protein levels of c-Myc (Myc) are reduced dramatically during late stage erythroid maturation, coinciding with cell cycle arrest in G1 phase and enucleation, suggesting possible roles for c-Myc in
Introduction: This study presents an investigation of how authors of fanfiction seeks and generates information in their respective fandoms from a Serious Leisure Perspective. Method: The data has been gathered using seven semistructured interviews and analysed qualitatively. The participants of the study were all active members at the fanfiction website Archive of our own, AO3. Analysis: Empiric
During 2011, ÅF launched a service called Green Business Screening (GBS) that provides a situation analysis of the overall environmental performance of a company. The model measures a company’s external and internal environmental integration and evaluates sustainability work through ten categories within a company, where the focus changes from internal categories to external categories. GBS is a g
Within the circular economy, alternatives to fast-fashion include second-hand clothing consumption. The narratives surrounding second-hand clothing have shifted from the stigma of old, dirty, smelly clothing to trendy, sustainable, and bargain items. The environmental benefits of second-hand are realised through the increased use-intensity and avoided production of new garments. However, these ben
The performed study is a qualitative case study of the company Business Sweden. An inductive research approach has been used where we started by observing Business Sweden and subsequently applied suitable theories. The aim with the paper is to describe and analyze the aspects of management control in a multinational hybrid organization, by observing the process of centralizing the responsibility o
Drowning is the second global leading cause of unintentional injury death for children ages 1 to 14 years, and the fifth leading cause for people of all ages (excluding flood disasters and water transport incidents). Why is the risk of drowning so high? It is important to investigate existing situation: what are the reasons that create a danger, is there a main risk group, how the risk of drownin
When live theatre is broadcast in real time at cinemas around the world, there is a gap in the current terminology. ’Mediatised live’ is a new expression, established in this thesis, to name the media form which has revolutionised the way of experiencing live theatre by broadcasting theatre live to venues around the world. By asking the question ‘Is the need for liveness dying?’ this thesis invest
Halvledarindustrin har en form av immaterialrätter avsedd särskilt för dem: Kretsmönsterrätter. Dessa introducerades i USA 1984 i syfte att skydda den amerikanska halvledarindustrin från konkurrens från östra Asien, huvudsakligen Japan. Den ersatte principen om nationell behandling med den materiella ömsesidighetsprincipen, som är normen inom immaterialrätt. Detta tillät USA att tvinga andra ländeThe semiconductor industry has a sui generis IP type dedicated to it: the semiconductor topography right. This right was introduced in 1984 with the purpose of protecting the U.S. semiconductor industry from East Asian, mainly Japanese, competition. It replaced the principle of treatment on a national basis that is the norm in IP law with one of material reciprocity, which allowed the U.S. to stro
