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Background: Laryngo-pharyngeal reflux (LPR) is assumed to be the most common cause of posterior laryngitis (PL). Since LPR is found in healthy subjects, and PL patients are not improved by acid-reducing therapy, other aetiologies to PL must be considered. The aims of this study in PL were to investigate the prevalence of acid reflux in the proximal oesophagus and functional gastrointestinal sympto
Recent studies on young men from the general population have demonstrated geographic and ethnic differences in semen quality. The aim of this study was to investigate whether reported ethnic differences in semen quality might be associated with the maternally derived CAG and GGN polymorphisms in the androgen receptor gene or paternal ethnicity. In total 114 military conscripts from Latvia were inc
To be able to robustly propagate P. falciparum at optimal conditions in vitro is of fundamental importance for genotypic and phenotypic studies of both established and fresh clinical isolates. Cryo-preserved P. falciparum isolates from Ugandan children with severe or uncomplicated malaria were investigated for parasite phenotypes under different in vitro growth conditions or studied directly from
Objectives: To investigate gender differences in daily smoking prevalence in different age groups in southern Sweden. Methods: The 2004 public-health survey in Skåne is a cross-sectional study. A total of 27,757 persons aged 18-80 years answered a postal questionnaire, which represents 59% of the random sample. A logistic regression model was used to investigate the associations between gender and
Venous thromboembolism (VTE) clusters in families, but the familial risk of VTE has only been determined in first-degree relatives. This nationwide study aimed to determine the familial risk of VTE in first-, second- and third-degree relatives of affected individuals. The Swedish Multi-Generation Register was linked to Hospital Discharge Register data for the period 1987-2009. This was a case-coho
Objective. To analyse the management of muscle-invasive bladder cancer in a population-based national register, and specifically to investigate the role of curative therapy (i.e. cystectomy or radiotherapy) in relation to patient, tumour and hospital characteristics. Material and methods. The Swedish Bladder Cancer Register covers more than 90% of all patients in the country who have been diagnose
Background and Purpose-Although many stroke patients are young or middle-aged, risk factor profiles in these age groups are poorly understood. Methods-The Stroke in Young Fabry Patients (sifap1) study prospectively recruited a large multinational European cohort of patients with cerebrovascular events aged 18 to 55 years to establish their prevalence of Fabry disease. In a secondary analysis of pa
Villkorlig frigivning infördes i svensk rätt 1906 för att möjliggöra en kontrollerad övergång från fängelsestraffets frihetsberövande till livet i frihet. Reglerna var då fakultativa och endast tillämpliga för långtidsdömda. Sedan 1906 har institutet om villkorlig frigivning successivt utvidgats och utgör idag en huvudregel som ska ske efter två tredjedelar av avtjänat fängelsestraff, dock tidigasParole was introduced into Swedish law in 1906 to enable a controlled transition from imprisonment to life in freedom. Initially, the rules were discretionary and applicable only to long-term prisoners. Since 1906, the scope of parole has gradually expanded and now constitutes the general rule, allowing release after two thirds of the prison sentence has been served, though not earlier than 30 day
In response to escalating public health challenges, particularly concerning mental health issues among youth, manual-based interventions have gained prominence in Sweden. These interventions are increasingly seen as integral components of proactive measures to address the escalating rates of mental illness. This study focuses on the implementation of the evidence-based program Youth Awareness of M
The aim of this research project was to create a bioinformatic image analysis pipeline for the investigation of lymphocytes in healthy human lungs. The lung is an important organ to study as it provides a fast way for pathogens to enter the body. Therefore, the pulmonary immune system must be further investigated in both healthy and diseased tissue. In order to do comparative studies, we need to c
Street-level bureaucrats play a vital role in the successful implementation of policies, and their actions significantly shape the outcomes of public welfare programs. In recent years, Swedish social services have faced criticism for their inability to adequately support children at risk of being recruited into criminal networks, despite Sweden's history of having one of the world's best s
Due to the world’s growing population and an increase in food demand, new innovative food products need to be developed to maximize the use of limited farmland. Because of global warming and the fact that plant based products generate less greenhouse gases than meat based products, research should focus on new plant-based protein sources. Rapeseed press cake is a residue from rapeseed oil producti
As the greenhouse gas emissions keep on increasing the need for solutions to help reduce emissions across all sectors has never been greater. The European Union has pointed out green hydrogen as a step in increasing the sustainability of the energy sector in Europe. Goals has been set to boost the development of hydrogen technology since the green hydrogen production today is only existing in an i
Reducing microorganisms by UV light is has been commonly used for drinking water for many years. In other liquid products like apple juice it is a rather novel application. The advantages would be that quality parameters like aromas and vitamins are less affected by the UV treatment compared to a heat treatment. Furthermore it would probably be cheaper, as the lamps need less electrical energy tha
The genetic causes of familial breast cancer are still unclear, where only less than 20% have evident germline mutations. Most studies focus on mutations that cause a direct impact in the protein, disregarding the synonymous variants, where the codon is changed but the amino acid encoded remains the same. Synonymous variants can affect mRNA stability and translation, by differences in codon usage
Relapsed or recurrent breast cancer is the chief cause of breast cancer related deaths and it is estimated that one-third of breast cancer patients would likely suffer a relapse. Due to high mortality and incidence, recurrent breast cancer requires better means of prediction, prevention and treatment. The AFFIRM platform uses recombinant antibody technology and selected reaction monitoring (SRM) m
Previous studies have found that launch prices reflect the therapeutic gains of pharmaceuticals (for instance: Ekelund and Persson, 2003, on Sweden and Lu and Comanor, 1998, on the US). Furthermore, Howard et al (2015) found that purely pharmaceutical costs to “Medicare” at launch for new anticancer drugs increased annually, from 1995-2013, after controlling for health benefits and inflation. This
