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Breast cancer screening with digital breast tomosynthesis : comparison of different reading strategies implementing artificial intelligence

OBJECTIVES: Digital breast tomosynthesis (DBT) can detect more cancers than the current standard breast screening method, digital mammography (DM); however, it can substantially increase the reading workload and thus hinder implementation in screening. Artificial intelligence (AI) might be a solution. The aim of this study was to retrospectively test different ways of using AI in a screening workf

Sex differences in presentation of atrial fibrillation : Findings from 30-day ambulatory monitoring in real-world practice

Background: Women are less likely to receive oral anticoagulation or ablation for treatment of atrial fibrillation (AF). Identification of sex differences in arrhythmia characteristics and symptoms may lead to a better understanding of potential reasons for these differences. Objectives: To determine sex differences in AF with respect to heart rate, duration, burden, and symptoms in patients under

Optically pure lactic acid production from lignocellulosic biomass

Lactic acid is a platform chemical that can be used for many applications. More recently, optically pure lactic acid—L- or D-lactic acid enantiomers—have been used for the polymerisation to poly-lactic acid (PLA). The possibility of tailoring the properties of this bioplastic by adjusting the ratio of each enantiomer might help to accelerate the substitution of petroleum-based plastics with bio-ba

Prenatal pesticide exposure and respiratory health outcomes in the first year of life : Results from the infants’ Environmental Health (ISA) study

Background: Growing evidence suggests that pesticide exposure may influence respiratory health, but data in young children are very limited. We examined the association of prenatal pesticide exposure with lower respiratory tract infections (LRTIs) and wheeze at one year of age in children from the Infants' Environmental Health (ISA) study in Costa Rica. Methods: We measured seven pesticide metabol

Health care utilisation among older people with Down syndrome compared to specific medical guidelines for health surveillance : a Swedish national register study

Background: Specific medical guidelines for health surveillance exist for people with Down syndrome (DS) since 25 years but knowledge of adherence to the guidelines is lacking. The guidelines were developed to avoid unnecessary suffering from preventable conditions. The aims of the study were to investigate 1) planned health care visits in relation to the co-morbidities described in specific medic

A phase III study of INCB054828 as adjuvant therapy in patients (pts) with high-risk urothelial carcinoma (UC) harboring fibroblast growth factor receptor 3 (FGFR3) genomic alterations

Background: After neoadjuvant chemotherapy (NAC), about 20% of pts with muscle-invasive UC are found to have advanced pT-stage or lymph node involvement and 5-year overall survival (OS) of them is < 30%. Tumor samples from these pts may provide information about chemotherapy resistance, and may predict for the activity of new drugs given postoperatively. Alterations of FGFR3 gene represent a thera

Self-gated fetal cardiac MRI with tiny golden angle iGRASP : A feasibility study

PURPOSE: To develop and assess a technique for self-gated fetal cardiac cine magnetic resonance imaging (MRI) using tiny golden angle radial sampling combined with iGRASP (iterative Golden-angle RAdial Sparse Parallel) for accelerated acquisition based on parallel imaging and compressed sensing.MATERIALS AND METHODS: Fetal cardiac data were acquired from five volunteers in gestational week 29-37 a

Spatial Statistical Modeling of Insurance Risk An epidemiologist approach to car insurance

Spatial models, such as the Besag, York and Mollie (BYM)model, have long been used in epidemiology and disease mapping. A commonproblem in these subjects is the modelling of number of disease eventsper region; here the BYM models provides a holistic framework for bothcovariates and dependencies between regions.We use these tools to assess the relative insurance risk associated withthe policyholder

Hereditary ApoA-I-related amyloidosis: aggregation propensity in the presence of ECM components and modulation of cholesterol efflux

Apolipoprotein A-I (ApoA-I) is the most predominant protein of high-density lipoprotein (HDL), which is an essential component for reverse cholesterol transport (RCT). ApoA-I has many health-promoting functions, such as anti-atherosclerosis and antioxidant properties; however, carriers of certain rare mutations in the APOA1 gene suffer from a disease called hereditary ApoA-I-related amyloidosis. A

Risk factors for hip fractures in a middle-aged population: a study of 33,000 men and women.

Knowledge about subjects who sustain hip fractures in middle age is poor. This study prospectively investigated risk factors for hip fracture in middle age and compared risk factors for cervical and trochanteric hip fractures. The Malmo Preventive Project consists of 22,444 men, mean age 44 years, and 10,902 women, mean age 50 years at inclusion. Baseline assessment included multiple examinations

A Spatial Approach to Environmental Risk Assessment of PAH Contamination.

The extent of remediation of contaminated industrial sites depends on spatial heterogeneity of contaminant concentration and spatially explicit risk characterization. We used sequential Gaussian simulation (SGS) and indicator kriging (IK) to describe the spatial distribution of polycyclic aromatic hydrocarbons (PAHs), pH, electric conductivity, particle aggregate distribution, water holding capaci

EU's Strategy in its Trilateral Relationships with China and the US - China's Accession to the WTO

China's accession to the WTO was perceived as the West integrating the East into the international economy with market economy reforming the planned economy. The major actors, the United States (US) and the Euorpean Union (EU), with similar economic structures and ideologies were expected to cooperate and bargain the best offers from China. However, while the US adopted a confrontational appro

Jaha, ska vi börja räkna repliker nu? : om skådespelerskors lika rätt på den svenska teaterscenen

All people, regardless of gender, are entitled to participate in cultural life. 41% of the permanent actors and actresses at the Royal Dramatic Theater in Stockholm are women. Only 34% of the Malmö Theater roles in 2009 went to actresses. There is a male norm, not only in Swedish society, but also in the Swedish theater. How does this norm look like and what methods are required to change it? Eve

Modelling the impact of climate change on future carbon dynamics of northern peatlands

Northern peatlands, spanning across vast regions of the northern hemisphere, are critical carbon reservoirs essential for global carbon cycling and climate regulation. Their dual role as long-term atmospheric carbon dioxide (CO2) sinks and the largest natural source of methane (CH4) in the northern hemisphere allows them to accumulate more carbon than they emit, helping to mitigate the rise in atm

Hårdare tag mot unga – En granskning av lagstiftningen om straffskärpningar för unga lagöverträdare

Denna uppsats undersöker motiven bakom den kriminalpolitiska utvecklingen i Sverige när det gäller straffskärpningar för unga lagöverträdare. Fokus ligger särskilt på avskaffandet av ungdomsreduktionen för unga myndiga vid allvar-lig brottslighet, samt på det senaste förslaget om ytterligare straffskärpningar även för omyndiga lagöverträdare (SOU 2024:39). För att svara på frågeställningarna redoThis thesis examines the motives behind recent developments in Swedish criminal policy concerning increased sentences for young offenders. It focus-es on the abolition of the juvenile reduction for young adults in cases of seri-ous crime, as well as on the recent proposal for further increases in sentences for underage offenders (Swedish Government Official Reports 2024:39). To fulfill the purpose

Diffusion Tensor Imaging in the Cervical Spinal Cord: Implementing methods for acquisition, processing and evaluation

Diffusion tensor magnetic resonance imaging (DT-MRI or DTI) is an imaging technique that is sensitive to the diffusion movement of water contained in tissue. It is used to quantify parameters such as the diffusivity and its directionality. Because diffusion is intimately connected to the tissue microarchitecture DTI is one of the few techniques that can quantify tissue microstructure non-invasivel

Moder Svea fjättrad : En narrativ analys av Sverigedemokraternas politik med fokus på historiekultur och historiebruk

Syftet med denna uppsats är att analysera hur Sverigedemokraterna använder historia för att förmedla en berättelse om Sveriges historia som ger riktlinjer för nutiden. Frågorna jag ställer handlar om hur deras berättelse är uppbyggd, vilka deras syften är och varför historia är viktigt för deras politik. Jag undersöker också om det finns ändringar i deras berättelse över tid. Jag har analyserat inThe subject of this thesis is derived from the scientific problem of the encounter between history and politics. The aim is to analyse the Sweden Democrats' use of history which manifests itself in their political rhetoric. Specifically, the importance of their interest in history in their struggle to attain dominance over the interpretation and arrangement of Swedish history as a whole. My pr