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The genetic background of familial, late-onset colorectal cancer (CRC) (i.e., onset > age 50 years) has not been studied as thoroughly as other subgroups of familial CRC, and the proportion of families with a germline genetic predisposition to CRC remains to be defined. To define the contribution of known or suggested CRC predisposition genes to familial late-onset CRC, we analyzed 32 well-establi
Interactions between immune cells such as T cells and antigen-presenting cells (APCs) are integral for mounting an adaptive immune response. The interaction between the T cell receptor (TCR) and the antigen-presenting major histocompatibility complex (pMHC) on a contacting T cell and APC, is widely accepted to be the key interaction. If the interaction is favourable, then T cell activation occurs.
In this thesis, a microfluidics platform with high-speed imaging system was built to investigate gas-liquid flow in single microchannel and interfacial instability in porous media with microchannel network:The mass transfer of slug flow in the rectangular and square microchannels was experimentally studied by using water as liquid phase and CO2 as gas phase. Depending on flow rates, flow patterns
Gas-liquid displacement in porous media widely exists in many terrestrial/extraterrestrial subsurface resource extraction and utilization applications. The typical fingering displacement during gas invading has been well identified through extensive research efforts. Yet, the evolution of fingering structures after invading breakthrough is rarely reported. Herein, through a joint approach of exper
Optical microscopy has revolutionized the way we understand our world and has become a crucial tool in a range of disciplines such as biology, physics, chemistry, and material sciences. The development of new microscopy techniques has been capital to its success and wide applicability. A prominent example is the recent development of methods that allow imaging in three dimensions. This has been a
The practice of product destruction, whereby retailers or manufacturers dispose of viable consumer products such as unsold goods or customer returns, is an extreme expression of the linearity of our current production-consumption system. This qualitative exploratory study aims to uncover why companies engage in this highly unsustainable and resource-inefficient behaviour and to explore the potenti
Detection of single, itinerant microwave photons is an important functionality for emerging quantum technology applications as well as of fundamental interest in quantum thermodynamics experiments on heat transport. In a recent experiment [W. Khan et al., Nat. Commun. 12, 5130 (2021)], it was demonstrated that a double quantum dot (DQD) coupled to a microwave resonator can act as an efficient and
Systemic fungal infections are associated with significant morbidity and mortality, and Candida albicans is the most common causative agent. Recognition of yeast cells by immune cell surface receptors can trigger phagocytosis of fungal pathogens and a pro-inflammatory response that may contribute to fungal elimination. Nevertheless, the elicited inflammatory response may be deleterious to the host
Aims: Information on standards including structure- and process-based metrics and how exercise-based cardiac rehabilitation (EBCR) is delivered in relation to guidelines is lacking. The aims of the study were to evaluate standards and adherence to guidelines at Swedish CR centers and to conduct a cost analysis of the physiotherapy-related activities of EBCR. Methods and Results: EBCR standards at
Recent evidence suggests that targeting S100A9 reduces pathological inflammation in abdominal sepsis. Herein, we investigated the role of S100A9 in neutrophil extracellular trap (NET) formation in septic lung damage. NETs were detected by electron microscopy in the lung and by confocal microscopy in vitro. Stimulation of isolated mouse bone marrow-derived neutrophils with S100A9 triggered formatio
Objective: Asthma is divided into various distinct phenotypes on the basis of clinical characteristics, physiological findings, and triggers, and phenotyping is usually performed in a hypothesis-driven univariate manner. However, phenotyping can also be performed using computer algorithms to evaluate hypotheses-free relationships among many clinical and biological characteristics. We aimed to iden
Electrodeposition of metals in templates of nano-porous anodic aluminum oxide (NP-AAO) is a versatile way of fabricating ordered arrays of metal nanowires. Thanks to the self-arranged long-range hexagonal order of the pores, electrodeposition in NP-AAO is an easily scalable bottom-up synthesis route and an attractive alternative to traditional top-down fabrication methods such as electron beam lit
Background: Epidemiological studies of associations between metabolites and cancer risk have typically focused on specific cancer types separately. Here, we designed a multivariate pan-cancer analysis to identify metabolites potentially associated with multiple cancer types, while also allowing the investigation of cancer type-specific associations. Methods: We analysed targeted metabolomics data
Background: Previous epidemiological studies have reported associations of pesticide exposure with poor cognitive function and behavioral problems. However, these findings have relied primarily on neuropsychological assessments. Questions remain about the neurobiological effects of pesticide exposure, specifically where in the brain pesticides exert their effects and whether compensatory mechanism
In this paper, the effects of internal coolant crossflow on double-jet holes were simulated and compared with two rows of cylindrical holes under three blowing ratios (M = 0.5, 1.0, and 1.5), with an established and validated turbulence model. The results show that double-jet holes can provide better film cooling performance for the three different blowing ratios compared with cylindrical holes. A
The aim was to study the potential effect of neighborhood deprivation on incident and fatal coronary heart disease (CHD) in patients with bipolar disorder. This was a nationwide cohort study which included all adults aged 30 years or older with bipolar disorder (n = 61,114) in Sweden (1997–2017). The association between neighborhood deprivation and the outcomes was explored using Cox regression an
Background: There are indications that early-life exposure to perfluoroalkyl substances (PFAS) can impact neurodevelopment, but results are inconclusive. The objective was to investigate if high early-life exposure to primarily perfluorohexanesulfonic acid (PFHxS) and perfluorooctanesulfonic acid (PFOS) increases the risk of developmental language disorder in children up to seven years of age.Meth
To improve film cooling effectiveness of a gas turbine blade, a kind of plasma ac-tuator is introduced on the blade surface. The effect of three arrangements of plasma actuators on flow characteristics and film cooling performance is numer-ically investigated by a verified turbulence model. Results show that the coolant air under plasma is pulled down to the wall, and the near-wall air is sped up
Ultrafast electron dynamics in quantum cascade lasers hold enormous potential for the implementation of intense, compact mode-locked terahertz sources, squeezed terahertz light, frequency mixers, and comb-based metrology systems. Yet the important sub-cycle dynamics have been notoriously difficult to access in operational terahertz quantum cascade lasers. Here we show the first field-resolved two-
