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Biomedical science is rapidly developing in terms of more transparency, openness and reproducibility of scientific publications. This is even more important for all studies that are based on results from basic semen examination. Recently two concordant documents have been published: the 6th edition of the WHO Laboratory Manual for the Examination and Processing of Human Semen, and the Internationa

SummaryWe describe the collection of cohorts together with the analysis plan for an update of the fracture risk prediction tool FRAX with respect to current and novel risk factors. The resource comprises 2,138,428 participants with a follow-up of approximately 20 million person-years and 116,117 documented incident major osteoporotic fractures.IntroductionThe availability of the fracture risk asse

The exploitation of ultrafast electron dynamics in quantum cascade lasers (QCLs) holds enormous potential forintense, compact mode-locked terahertz (THz) sources, squeezed THz light, frequency mixers, and comb-basedmetrology systems. Yet the important sub-cycle dynamics have been notoriously difficult to access in operationalTHz QCLs. Here, we employ high-field THz pulses to perform the first ultr

Markovian master equations provide a versatile tool for describing open quantum systems whenmemory effects of the environment may be neglected. As these equations are of an approximatenature, they often do not respect the laws of thermodynamics when no secular approximation isperformed in their derivation. Here we introduce a Markovian master equation that isthermodynamically consistent and provid

Hybrid perovskites are a novel type of semiconductors that show great potential for solution-processed optoelectronic devices. For all applications, the device performance is determined by the quality of the solution-processed perovskite thin films. During solution processing, the interaction of solvent with precursor molecules often leads to the formation of solvate intermediate phases that may d

Cross-ecosystem subsidies are important as their recipients often rely on them to supplement in situ resource availability. Global warming has the potential to alter the quality and quantity of these subsidies, but our knowledge of these effects is currently limited. Here, we quantified the biomass and diversity of the invertebrates exchanged between freshwater streams and terrestrial grasslands i

Aims: To investigate associations between trust in the healthcare system and all-cause, cardiovascular, cancer and other causes mortality. Study design: Prospective cohort study. Methods: A public health questionnaire was conducted in 2008 in Scania, the southernmost part of Sweden, with a 54.1% participation rate with a postal questionnaire and three reminders. In this study 24,833 respondents we

Mass production and consumption based on virgin materials have been the mainstream practice for decades across industrialised nations. Resource consumption has reached an unsustainable level, leading to devastating environmental impacts. For a more sustainable future, not only environmentally but economically and socially, material cycles need to be slowed down and, if possible, closed. Upcycling

Purpose: To determine the effect of glaucomatous visual field (VF) damage close to the point of fixation, called threat-to-fixation (TTF), on vision-related quality of life (VRQoL) in open-angle glaucoma. Methods: A total of 239 patients from the Glaucoma Intensive Treatment Study (GITS) were included in this analysis. The second VF of patients with newly diagnosed primarily early glaucoma was eva

IntroductionUse of long-term oxygen therapy (LTOT) for more than 15 h per day does not reduce mortality or hospitalizations, but may increase the risk of adverse events. We evaluated the relationship between daily oxygen use duration and adverse events, symptoms, and health status in patients on LTOT.MethodsThis was a cross-sectional survey study of a random sample (N = 650) of adults with ongoing

It is relevant to consider uncertainty in individual predictions when quantitative structure-activity (or property) relationships (QSARs) are used to support decisions of high societal concern. Successful communication of uncertainty in the integration of QSARs in chemical safety assessment under the EU Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH) system can be faci

We calculate the survival probability of a special state which couples randomly to a regular or chaotic environment. The environment is modeled by a suitably chosen random matrix ensemble. The exact results exhibit non-perturbative features as revival of probability and non-ergodicity. The role of background complexity and coupling complexity is discussed as well.

Biosensors based on nanomaterials constitute an emerging area of interdisciplinary research. In particular in electrochemical sensors, electron transfer cascades can be used for defined signal generation. Our study describes the investigation of silica nanoparticles (SiNPs), DNA, cytochrome c (cyt c) and cellobiose dehydrogenase (CDH) for the development of catalytically active multi-protein assem

Genetic factors have been implicated in stroke risk, but few replicated associations have been reported. We conducted a genome-wide association study (GWAS) for ischemic stroke and its subtypes in 3,548 affected individuals and 5,972 controls, all of European ancestry. Replication of potential signals was performed in 5,859 affected individuals and 6,281 controls. We replicated previous associatio

Background: Biomass combustion contributes to the production of ambient particulate matter (PM) in rural environments as well as urban settings, but relatively little is known about the health effects of these emissions. The aim of this study was therefore to characterize airway responses in humans exposed to wood smoke PM under controlled conditions. Nineteen healthy volunteers were exposed to bo

Introduction and purpose In recent years, there has been renewed interest in using unicompartmental knee arthroplasty (UKA). Several studies have reported increasing numbers of UKAs for osteoarthritis in patients who are less than 65 years of age, with low revision rates. To describe and compare the use and outcome of UKA in this age group, we have combined data from the Australian and Swedish kne

We investigate theoretically a scheme for spectroscopy of electrons emitted by an on-demand single-particle source. The total system, with an electron turnstile source and a single-level quantum dot spectrometer, is implemented with edge states in a conductor in the quantum Hall regime. Employing a Floquet scattering approach, the source and the spectrometer are analyzed within a single theoretica