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Popular Abstract in Swedish Typ 1-diabetes är en allvarlig, autoimmun, sjukdom och Sverige har världens näst högsta antal nya insjuknanden. Varje år diagnostiseras ca 700 individer i Sverige med sjukdomen som kan debutera i alla åldrar. Senare studier tyder dock på att barn med typ 1-diabetes blir allt yngre. Vi vet idag att ärftligheten är kopplad till en specifik gen vilket förklarar ca 30-50% aObjective The primary aim of this thesis was to test whether gestational exposure to environmental factors may induce islet autoimmunity. The second aim was to determine to what extent the exposure to viruses or other environmental factors is a risk factor for type 1 diabetes in the offspring. As children with type 1 diabetes have a higher risk of developing celiac disease (CD), an additional aim

We describe quantum-size and binding-site effects on the chemical and local field enhancement mechanisms of surface-enhanced resonance Raman scattering (SERRS), in which the pyridine molecule is adsorbed on one of the vertices of the Ag-20 tetrahedron. We first investigated the influence of the binding site on normal Raman scattering (NRS) and excited state properties of optical absorption spectro

This paper presents the development of an experimentally validated model that mechanistically comprehends the complex interaction between the gas-phase fluid dynamics, the mass transport of individual species, and the heterogeneous gas-surface reaction mechanism in a continuous cross-flow atomic layer deposition (ALD) reactor. The developed ALD gas-surface reaction mechanism, purely based on conse

Background: Mycobacterium goodii is a rare cause of significant infection. M. goodii has mainly been associated with lymphadenitis, cellulitis, osteomyelitis, and wound infection. Case presentation: A case of a 76-year-old Caucasian female is presented. The patient developed a prosthetic valve endocarditis caused by M. goodii. She had also suffered from severe neurological symptoms related to a se

A portable high resolution soft x-ray and extreme ultraviolet (EUV) spectrometer has been developed for spectroscopic research at the Shanghai Electron Beam Ion Trap (EBIT) laboratory. A unique way of aligning the grazing incidence spectrometer using the zero order of the grating is introduced. This method is realized by extending the range of the movement of the CCD detector to cover the zero ord

Novel strategies for specific tumour cell targeting are necessary in order to improve survival rates and to reduce side effects of current therapies in cancer patients. Hypoxia is a hallmark of solid tumours and one of the major driving forces for tumour progression. Targeting of the adaptive responses of cancer cells to hypoxia offers opportunities for tumour specific therapies. The aim of this

Dizziness in older people is associated with disability and reduced quality of life. Few studies have investigated how daily life is affected from the older person's perspective. Identifying barriers and resources in daily life could guide health care in how to direct efficient interventions. The aim of this study was to explore older persons' experiences of living with chronic dizziness.

The aim of this thesis was to explore and gain deeper insight into and understanding of mobility in public environments for people with acquired cognitive functional limitations (target group of this thesis) and of reasons why some of them do not use public transport. Using an explorative approach, the target group’s mobility was firstly discussed by experts in focus group interviews. Secondly the

A search for the production of single-top-quarks in association with missing energy is performed in proton-proton collisions at a centre-of-mass energy of [Formula: see text] with the ATLAS experiment at the large hadron collider using data collected in 2012, corresponding to an integrated luminosity of [Formula: see text] fb[Formula: see text]. In this search, the [Formula: see text] boson from t

We present a re-analysis of the Geneva-Copenhagen survey, which benefits from the infrared flux method to improve the accuracy of the derived stellar effective temperatures and uses the latter to build a consistent and improved metallicity scale. Metallicities are calibrated on high-resolution spectroscopy and checked against four open clusters and a moving group, showing excellent consistency. Th

Given electronic wave functions generated by the grasp2K relativistic atomic structure package, this program calculates diagonal magnetic dipole A(J) and electric quadrupole B-J hyperfine interaction constants and Lande g(J) factors. In addition the program computes diagonal and off-diagonal reduced hyperfine and Zeeman matrix elements and constructs the total interaction matrix for an atom in an

Film cooling effectiveness and its distribution characteristics on the gas turbine blade surface were investigated numerically. Seven rectangular ribs were located on the internal wall, and a film cooling hole had a compound inclined angle. The case with a compound angle of 45 degrees was designed to improve the lateral film cooling effectiveness on the downstream surface. The secondary flow jet f

Several studies of meteorites show that a large disruption of an asteroid occurred ca. 470 Ma in our solar system's asteroid belt. As a consequence, a large number of meteorite impacts occurred on Earth during the following few million years. The finding and characterization, for the first time, of planar deformation features in quartz grains from rocks collected at the Middle Ordovician Hummeln s

The electron-ion scattering experiment ELISe is part of the installations envisaged at the new experimental storage ring at the International Facility for Antiproton and Ion Research (FAIR) in Darmstadt, Germany. It offers an unique opportunity to use electrons as probe in investigations of the structure of exotic nuclei. The conceptual design and the scientific challenges of ELISe are presented.

The production of events with multiple high transverse momentum particles including charged leptons and jets is measured, using 1.04 fb(-1) of proton-proton collision data recorded by the ATLAS detector during the first half of 2011 at root s = 7 TeV. No excess beyond Standard Model expectations is observed, and upper limits on the fiducial cross sections for non-Standard Model production of these