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Summary Successful malaria transmission from the mosquito vector to the mammalian host depends crucially on active sporozoite motility. Sporozoite locomotion and host cell invasion are driven by the parasite's own actin/myosin motor. A unique feature of this motor machinery is the presence of very short subpellicular actin filaments. Therefore, F-actin stabilizing proteins likely play a central ro
Quality control of stabilized dredged sediment (DS) presents significant challenges due to its high-water content. Nowadays, many in-situ and laboratory tests have been used to evaluate the quality of treated DS, and the dominant method is 28-day unconfined compressive strength that can be done on undisturbed samples from the field and the laboratory. Due to the waiting period to get results from
Background: People with chronic inflammatory arthritis (IA) often have a reduced work ability. Consequently, they are at high risk of losing their jobs and being permanently excluded from the labor market. Therefore, we developed a new context-specific vocational rehabilitation intervention for people with IA based on the Medical Research Council’s framework for complex interventions. This interve
Background: Cardiac allograft vasculopathy is characterized by increased coronary intimal thickness and is a leading cause of death in heart transplant (HTx) recipients despite the routine use of statins. The experience with inhibitors of proprotein convertase subtilisin-kexin type 9 in HTx recipients is limited. Our hypothesis was that lowering cholesterol with the proprotein convertase subtilisi
Changes in biomarker levels of Alzheimer’s disease (AD) reflect underlying pathophysiological changes in the brain and can provide evidence of direct and downstream treatment effects linked to disease modification. Recent results from clinical trials of anti–amyloid β (Aβ) treatments have raised the question of how to best characterize the relationship between AD biomarkers and clinical endpoints.
Multi-functional molecules with spirocyclic acetal structures have recently emerged as attractive monomers to prepare high-performance polymers, which may subsequently be de-polymerized and recycled under specific physicochemical conditions. Spirocyclic acetal structures can be formed by condensation of a suitable aldehyde or ketone with a polyol so that the functionalities necessary for the polym
Opening remarks – These guidelines are the result of dis-cussions within a diverse group of RSA researchers. They were approved in December 2023 by the board and selected members of the International Radiostereometry Society to update the guidelines by Valstar et al. [1]. By adhering to these guidelines, RSA studies will become more transparent and consistent in execution, presentation, reporting,
Purpose: To develop a deep learning-based algorithm that automatically and accurately classifies patients as either having pulmonary emboli or not in CT pulmonary angiography (CTPA) examinations. Materials and methods: For model development, 700 CTPA examinations from 652 patients performed at a single institution were used, of which 149 examinations contained 1497 PE traced by radiologists. The n
Since the last edition of this book (2014), progress has been astonishing in all areas of Natural Language Processing, with recent achievements in Text Generation that spurred a media interest going beyond the traditional academic circles. Text Processing has meanwhile become a mainstream industrial tool that is used, to various extents, by countless companies. As such, a revision of this book was
Sagarmatha (Everest) has long been recognised as one of the principal goals of global adventure tourism. Supported by high-altitude workers, paying climbers on Sagarmatha have the opportunity to tread in the footsteps of colonial pioneers such as George Mallory and Sir Edmund Hillary. Ever since the first attempt was made to summit Sagarmatha there has been an appreciation amongst the climbing com
As a component of myeloablative conditioning before allogeneic hematopoietic stem cell transplantation (HSCT), Total Body Irradiation (TBI) is employed in radiotherapy centers all over the world. In recent and coming years, many centers are changing their technical setup from a conventional TBI technique to multi-isocenter conformal arc therapy techniques such as Volumetric Modulated Arc Therapy (
A fuel cell is an electrochemical device that transforms chemical energy into electrical energy and heat. It occurs through a controlled chemical reaction. Among its essential components are the porous electrodes, which play a pivotal role in the operation of the fuel cells. These electrodes are crucial because they facilitate the efficient flow of reactants to the reaction sites, thereby driving
Purpose: Prior research has proposed a number of scales measuring the customer experience (CX), which tend to conceptualize and operationalize CX differently, raising potential confusion among researchers (e.g. regarding which scale to use). Addressing this issue, this article conducts a systematic review to inventorize key CX scales and assess their theoretical rigor, with a focus on the identifi
Future connected vehicles will require high-performance communication technologies for advanced cooperative driving applications such as maneuvering and cooperative perception. mmWave communications can meet the bandwidth requirements of such applications, but the typically harsh propagation conditions of vehicular environments hinder the broad adoption of mmWave devices on cars. Reconfigurable in
Objectives: To perform a descriptive analysis of a series of patients with recurrent macroscopic haematuria after a primary standard evaluation including computed tomography urography (CTU) and cystoscopy negative for urinary bladder cancer (UBC) and upper tract urothelial cancer (UTUC) and to identify potential factors associated with occurrence of recurrent macroscopic haematuria. Methods: All p
Climate change has diverse effects on the planet’s environment, including changes and shifts in the distribution and abundance of species. In this paper, we present a robust prediction ensemble algorithm for the current and future species distribution of Aegilops tauschii. Four modeling approaches were trained using various environmental variables (bioclimatic and soil variables) to accurately pre
Protein tyrosine phosphatases (PTPs) possess a conserved mobile catalytic loop, the WPD-loop, which brings an aspartic acid into the active site where it acts as an acid/base catalyst. Prior experimental and computational studies, focused on the human enzyme PTP1B and the PTP from Yersinia pestis, YopH, suggested that loop conformational dynamics are important in regulating both catalysis and evol
Researchers using eye tracking are heavily dependent on software and hardware tools to perform their studies, from recording eye tracking data and visualizing it, to processing and analyzing it. This article provides an overview of available tools for research using eye trackers and discusses considerations to make when choosing which tools to adopt for one's study.
