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Hematopoietic stem cells (HSCs) maintain blood through self-renewal and differentiation. Although HSC transplantation is the only cure for various blood disorders, generating and maintaining HSCs in vitro remains challenging, partly due to a limited understanding of the cellular and molecular mechanisms underlying human HSC ontogeny. In embryos, definitive HSCs arise from hemogenic endothelium via
Focusing on the photoinduced electron transfer properties of the D-D-A molecule ((TPA-TT)-BODIPY-C60) in an external electric field (Fext), the excited-state properties in which the double-donor molecule is excited to form three charge-separated states were simulated. The charge-Transfer processes of these three charge-separated states were investigated by considering the two donors as a whole ((T
Recent work showing a strong quality improvement of the Si/SiO2 material system by low temperature atomic hydrogen annealing (AHA), and the fact that III-V semiconductors outperform Si in many applications makes the investigation of AHA on III-V/high-k interfaces to a very interesting topic. In this work, the potential of AHA as a low temperature annealing treatment of InGaAs metal-oxide-semicondu
During Achilles tendon healing in rodents, besides the expected tendon tissue, also cartilage-, bone- and fat-like tissue features have been observed during the first twenty weeks of healing. Several studies have hypothesized that mechanical loading may play a key role in the formation of different tissue types during healing. We recently developed a computational mechanobiological framework to pr
Objective: To explore how cancer survivors have experienced their contacts with primary care after being diagnosed with cancer, focusing on the integration between cancer specialist and primary care, and participants’ views on what could make primary care services better at catering to the needs of cancer survivors. Design: A qualitative study in which data was collected through semi-structured di
In-situ characterization of combusting iron particles is of great importance for understanding the combustion mechanism. Here, magnified holographic imaging is employed to investigate the transient morphology and dynamics of iron particles during combustion. The volume expansion behavior of combusting particles (mean diameter: 85 μm) is observed in situ. The particle volume increases to eight time
Passivation behavior of a N- and V-containing martensite stainless steel was studied by synchrotron-based near ambient-pressure X-ray photoelectron spectroscopy, electrochemical analyses, and thermodynamic calculation. The passive film consists of Cr3+, Fe(2, 3)+, and V(2, 3, 4)+ oxides as inner layer, and Cr3+ and Fe3+ hydroxides as outer layer. Austenitization at 1080 oC (rather than 1010 oC) an
Stroke represents a considerable burden of disease for both men and women. However, a growing body of literature suggests clinically relevant sex differences in the underlying causes, presentations and outcomes of acute ischaemic stroke. In a recent study, we reported sex divergences in lesion topographies: specific to women, acute stroke severity was linked to lesions in the left-hemispheric post
To investigate aging effect on the passive film of Ni23Cr15Mo and Ni22Cr9Mo3Nb, synchrotron-based X-ray photoelectron spectroscopy (XPS) was used to analyze the structure and composition of the air-formed passive film on the alloys. The corrosion resistance of the two Ni alloys in 1 M NaCl solution was evaluated with electrochemical cyclic polarization measurement. The synchrotron XPS measurement
BACKGROUND: Umbilical cord blood gases are routinely used by midwives and obstetricians for quality assurance of birth management and in clinical research. They can form the basis for solving medicolegal issues in the identification of severe intrapartum hypoxia at birth. However, the scientific value of veno-arterial differences in cord blood pH, also known as ΔpH, is largely unknown. By traditio
OBJECTIVE: This longitudinal study examines a possible causal effect between type 2 diabetes and ischemic heart disease (IHD) by using measurements on four occasions from the Swedish Statistics on Income and Living Conditions (SILC) together with nationwide healthcare registers.METHODS: This was a longitudinal study based on a random sample of men and women (n = 2014) from the Swedish population w
Investigating the optical properties of various chemical compounds using UV-vis spectrophotometers is an essential part of education in chemistry. However, commercial spectrophotometers are usually treated as "magic black boxes", where the dominant majority of optical elements are hidden "under the hood". This often limits understanding of the mechanisms behind the generation of spectral curves, w
OBJECTIVE: Orthostatic hypotension and resting heart rate (RHR) are associated with cardiovascular disease (CVD). However, it is unknown how these factors relate to subclinical CVD. We examined the relationship between orthostatic blood pressure (BP) response, RHR and cardiovascular risk factors, including coronary artery calcification score (CACS) and arterial stiffness, in the general population
Amyloid fibrils are associated with a number of different neurodegenerative diseases. Detailed knowledge of the fibril structure will be of importance in the search of therapy and may guide experiments to understand amyloid formation. In this paper we investigate the morphology of α-synuclein amyloid fibrils, associated with Parkinson’s disease, formed under different conditions. In particular, we
One of the core pathological features of Parkinson's disease (PD) is the loss of the dopaminergic nigrostriatal pathway which lies at the heart of many of the motor features of this condition as well as some of the cognitive problems. The importance of this pathological event is evident through the clinical benefits that are seen when patients with PD are treated with dopaminergic agents, at least
Background: Diet may impact important risk factors for endometrial cancer such as obesity and inflammation. However, evidence on the role of specific dietary factors is limited. We investigated associations between dietary fatty acids and endometrial cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC). Methods: This analysis includes 1,886 incident endometrial ca
Nonintrusive temperature measurement is crucial in combustion research. Here, we propose a thermometric technique based on femtosecond two-photon laser-induced fluorescence of carbon monoxide (CO-fs-TPLIF). A femtosecond laser with a wavelength of 230 nm was used as an excitation source. Owing to its intrinsic broad bandwidth, dual vibrational bands of the B1Σ+ ← X1Σ+ transition of CO can be simul
