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Cyclin-dependent kinase 1 (Cdk1) is an archetypical kinase and a central regulator that drives cells through G2 phase and mitosis. Knockouts of Cdk2, Cdk3, Cdk4, or Cdk6 have resulted in viable mice, but the in vivo functions of Cdk1 have not been fully explored in mammals. Here we have generated a conditional-knockout mouse model to study the functions of Cdk1 in vivo. Ablation of Cdk1 leads to a

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B-lymphoblastic leukemia/lymphoma (B-ALL) is the most common pediatric malignancy and the most commonly diagnosed adult lymphoblastic leukemia. Recent advances have broadened the spectrum of B-ALL, with DUX4 gene fusions implicated in a subclass occurring in adolescents and young adults and harboring a favorable prognosis. DUX4 fusions have been challenging to identify. We aimed to determine wheth

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Spatial Data Infrastructure (SDI) development is widely known to be a challenging process owing to its complex and dynamic nature. Although great effort has been made to conceptually explain the complexity and dynamics of SDIs, few studies thus far have actually modeled these complexities. In fact, better modeling of SDI complexities will lead to more reliable plans for its development. A state-of

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Every living organism is made up of cells, the smallest structural and functional unit of life. These organisms can further be classified on the basis of cell number as single-cell or multi-cell organism. Over time these primitive organisms have evolved leading to the formation of more complex machinery in higher organism. While it is tough and tedious to calculate the exact number of cells in theWater is an essential compoment of every living orgamism and forms a major part of the human body. Regulated water transport is crucial for proper cell functioning and body homeostasis. Cell, the smallest structural and functional unit of life, uses specialized water conducting pores made up of proteins to transport water across the plasma membrane by facilitated diffusion.The discovery of one of