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The comparative performance of existing models for prediction of type 2 diabetes across populations has not been investigated. We validated existing non-laboratory-based models and assessed variability in predictive performance in European populations.
Malignant melanoma (MM) patients are being treated with an increasing number of personalized medicine (PM) drugs, several of which are small molecule drugs developed to treat patients with specific disease genotypes and phenotypes. In particular, the clinical application of protein kinase inhibitors (PKI) has been highly effective for certain subsets of MM patients. Vemurafenib, a PKI targeting BR
In this study, different flavin adenine dinucleotide (FAD)-dependent glucose dehydrogenases (FADGDHs) were characterized electrochemically after "wiring" them with an osmium redox polymer [Os(4,4'-dimethyl-2,2'-bipyridine)(2)(PVI)(10)Cl](+) on graphite electrodes. One tested FADGDH was that recently discovered in Glomerella cingulata (GcGDH), another was the recombinant form expressed in Pichia pa
The etiology of male breast cancer is poorly understood, partly because of its relative rarity. Although genetic factors are involved, less is known regarding the role of anthropometric and hormonally related risk factors.
We report on the influence of hydrogen bromide (HBr) in situ etching on the growth of InP, GaP and GaAs nanowires. We find that HBr can be used to impede undesired radial growth during axial growth for all three material systems. The use of HBr opens a window for optimizing the growth parameters with respect to the materials' quality rather than only their morphology. Transmission electron microsc
Several strategic metals, elements and energy resources are about to run into scarcity in the near future under the present paradigm of use. A global systems model has been developed (WORLD) to assess the issue of scarcity and its implications for society. We show that scarcity may lead to “peak wealth”, “peak population”, “peak waste” and “peak civilization”, unless urgent counter-measures are sy
To highlight methodological challenges in the design and conduct of randomized trials of surgical interventions and to propose strategies for addressing these challenges. This paper focuses on three broad areas: enrollment; intervention; and assessment including implications for analysis. For each challenge raised in the paper, we propose potential solutions. Enrollment poses challenges in maintai
Purpose Population-based studies on violent crime and background factors may provide an understanding of the relationships between susceptibility factors and crime. We aimed to determine the distribution of violent crime convictions in the Swedish population 1973-2004 and to identify criminal, academic, parental, and psychiatric risk factors for persistence in violent crime. Method The nationwide
The intensive use of nano-sized titanium dioxide (TiO2) particles in many different applications necessitates studies on their risk assessment as there are still open questions on their safe handling and utilization. For reliable risk assessment, the interaction of TiO2 nanoparticles (NP) with biological systems ideally needs to be investigated using physico-chemically uniform and well-characteriz
Systemic lupus erythematous (SLE) is an autoimmune disorder that primarily affects young women and is characterized by inflammation in several organs including the kidneys, skin, joints, blood, and nervous system. Abnormal immune cellular and humoral responses play important roles in the development of the disease process. Impaired clearance of apoptotic material is a key factor contributing to ac
Hög belastning är ett bekymmer för många akutmottagningar, vilket har en negativ effekt på patientsäkerheten och minskar tillfredställelsen för patient och vårdgivare. För att korta ner väntetiderna kan upprättande av observationsenheter, OE, vara ett bra alternativ. Tidigare studier visar att OE kan minska kostnaderna för vården av patienten och vårdtiden. En kvantitativ retrospektiv studie genom
Bakgrund: Sexuell ohälsa är ett vanligt förekommande problem hos kvinnor postpartum. Syfte: Att undersöka kvinnors sexuella hälsa inom 6 månader efter en vaginal förlossning samt att kartlägga om samtal kring sex- och samlevnad tas upp på efterkontrollen. Metod: Kvantitativ tvärsnittsstudie genom webbaserad enkätundersökning. Resultat: Den sexuella hälsan, mätt med FSFI (Female Sexual Functi
In association with the refugee crisis in 2015, more people sought asylum in Sweden than ever before. The Swedish government initially pursued a relatively welcoming asylum policy with open borders and with a vision of maintaining the right to asylum. This moral attitude towards refugees would subsequently take a turn. On December 9 in 2015, the Bill "Specific measures during serious danger t
Matchfixning är ett är problem som hotar att rubba fotbollens integritet fundamentalt. Fotbollens värdegrund är och ska alltid vara kännetecknat av tävling på lika villkor vilket ska locka fram det bästa av utövarna. Matchfixning riskerar att omkullkasta den här värdegrunden. Vadhållningsrelaterad matchfixning innebär att en idrottslig aktör medvetet underpresterar i en tävling, i enlighet med en Match fixing is an issue that threatens to fundamentally distort the integrity of football. The basic principles and common values of football are, and should always be, characterized by competition on equal terms, designed to bring the players to perform at their absolute top. Match fixing puts this core value at risk of being toppled over. Match fixing related to betting implies that an athlete
Våld i nära relationer och särskilt mäns våld mot kvinnor, anses idag utgöra ett allvarligt samhällsproblem. Det finns studier som visar att ungefär vart tionde barn i Sverige någon gång har upplevt våld mellan närstående vuxna. Detta kan få förödande konsekvenser för barnet i form av både fysiska och psykiska skador. Att låta barn bevittna våld eller andra brottsliga gärningar mellan närstående äViolence in close relationships and especially men’s violence against women, is today considered a social problem. There are studies showing that approximately every tenth child in Sweden has ever experienced violence between related adults. This can cause devastating consequences for a child, such as both physical and mental injuries. Letting children witness violence or other criminal acts betwe
Entreprenadavtal avser i allmänhet omfattande och långvariga arbeten som inbegriper flera olika parter. Det är relativt vanligt förekommande att parterna har olika åsikt gällande hur ett specifikt avtalsvillkor ska tolkas. Det finns ingen entreprenadrättslig lagstiftning. Företrädare för BKK, Byggandets Kontraktskommitté, har framförhandlat standardkontrakt. Standardkontrakten har en stark ställniConstruction contracts generally refer to extensive and long-term projects involving several different parties. It is relatively common for the parties to have different opinions regarding how a specific contractual term should be interpreted. There is no construction contract law in the area. Hereby representatives of the BKK, the Construction Contracts Committee, have negotiated standard contrac
For Those About to Rock... – A study of views of the ensemble repertoire in the aesthetic programme in Swedish high schools In my paper I will present the result of an inquiry made in the aesthetic program in Swedish high schools. The survey covers nine different groups in three different schools in Skåne. As background to my study I have used experiences I have had during my practical workplace t
