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BACKGROUND: Diagnosing heart failure with preserved ejection fraction (HFpEF) remains challenging, particularly in older adults. While the Heart Failure Association (HFA)-PEFF and H2FPEF Scores offer structured diagnostic approaches, their clinical utility is still debated. This study aims to compare the diagnostic accuracy of HFpEF Scores versus inclusion criteria used in sodium-glucose cotranspo
In the Swedish context, ‘intergenerational Collaborative Housing’ and ‘Collaborative Housing for the second half of life’ (CH2L), based on the self-work model, were developed in the 1980s and 1990s. The chapter examines how ageing individuals developed caring practices and mutual support strategies in these collective housing forms and how such practices were adapted during the COVID-19 pandemic.
Ulnar nerve entrapment at the elbow (UNE) is the second most common compression neuropathy in the upper limb. Immediate return-to-work (RTW) after surgery is seldom possible due to restrictions and recovery demands. We aimed to explore RTW after UNE surgery and investigate factors contributing to variations. A prospective study with patients undergoing primary UNE surgery was conducted. Treatment
Modified ZYMO DNA/RNA miniprep extraction protocol written in a user friendly way to reduce in-process-decisions and process time. Sample type is organic soil, peat, from a degraded rich fenThis protocol includes modifications to tackle clogged filters. Samples were centrifuged for 45 seconds instead of 30 seconds in first pass through filters as 100 ul to 200 ul sample remained trapped above filt
Young adults presenting with knee pain, instability, or both after twisting the knee during sports or at work are commonly seen in primary care. If the symptoms and injury history correspond with suspicion of a torn anterior cruciate ligament (ACL) or meniscal injury, sometimes in combination with positive findings on magnetic resonance imaging, patients are often referred for surgical treatment.
Föreliggande avhandling består av fyra studier där det övergripande syftet med studierna var att utveckla ett mätinstrument för att bedöma vårdbehov och tidsåtgång relaterat till vilka personella resurser som krävs för att tillgodose aktuellt vårdbehov hos äldre boende på särskilda boenden inom kommunal äldreomsorg. Instrumentet har fått namnet Time in Care (TiC) och är uppdelat i två delar: Time
The purpose of this study was to explore and compare different countries in what motivated research participants’ decisions whether to share their de-identified data. We investigated European DIRECT (Diabetes Research on Patient Stratification) research project participants’ desire for control over sharing different types of their de-identified data, and with who data could be shared in the future
This study analyzes the association between neighborhood social class in childhood and later-life health trajectories, controlling for both class origin and class attainment in adulthood. We study the association between socio-spatial neighborhood conditions throughout childhood and a range of health outcomes in adulthood. To measure childhood conditions, we utilize unique longitudinal micro-data
Increasing demand for detecting single molecules in challenging environments has raised the bar for the fluorophores used. To achieve better resolution and/or contrast in fluorescence microscopy, it is now essential to use bright and stable dyes with tailored photophysical properties. While long fluorescence lifetime fluorophores offer many advantages in time-resolved imaging, their inherently low
Breast cancer (BC) risk for BRCA1 and BRCA2 mutation carriers varies by genetic and familial factors. About 50 common variants have been shown to modify BC risk for mutation carriers. All but three, were identified in general population studies. Other mutation carrier-specific susceptibility variants may exist but studies of mutation carriers have so far been underpowered. We conduct a novel case-
HIPPIE is a soft X-ray beamline on the 3 GeV electron storage ring of the MAX IV Laboratory, equipped with a novel ambient-pressure X-ray photoelectron spectroscopy (APXPS) instrument. The endstation is dedicated to performing in situ and operando X-ray photoelectron spectroscopy experiments in the presence of a controlled gaseous atmosphere at pressures up to 30 mbar [1 mbar = 100 Pa] as well as
Sanfilippo syndrome type C (mucopolysaccharidosis IIIC) is an early-onset neurodegenerative lysosomal storage disorder, which is currently untreatable. The vast majority of studies focusing on disease mechanisms of Sanfilippo syndrome were performed on non-neural cells or mouse models, which present obvious limitations. Induced pluripotent stem cells (iPSCs) are an efficient way to model human dis
Streptococcus pneumoniae (pneumococcus) resides asymptomatically in the nasopharynx but can progress from benign colonizer to lethal pulmonary or systemic pathogen. Both viral infection and aging are risk factors for serious pneumococcal infections. Previous work established a murine model that featured the movement of pneumococcus from the nasopharynx to the lung upon nasopharyngeal inoculation w
Organ-specific autoimmune diseases, such as type 1 diabetes, are believed to result from T-cell-mediated damage of the target tissue. The immune-mediated tissue injury, in turn, is known to depend on complex interactions between genetic and environmental factors. Nevertheless, the mechanisms whereby environmental factors contribute to the pathogenesis of autoimmune diseases remain elusive and repr
Controlling the nucleation and crystal growth in solution-processed metal halide perovskite (MHP) thin films is the pivotal point in fabricating homogenous and pinhole-free films. Using scalable coating and printing techniques, vacuum and gas flow-assisted drying processes turn out to be the most promising methods to induce nucleation and crystallization. Yet, the exact interplay and nature of the
The open-circuit voltage (Voc) of all-polymer solar cells (all-PSCs) is typically lower than 0.9 V even for the most efficient ones. Large energy loss is the main reason for limiting Voc and efficiency of all-PSCs. Herein, through materials design using electron deficient building blocks based on bithiophene imides, the lowest unoccupied molecular orbital (LUMO) energy levels of polymer acceptors
Recent advances in high-throughput sequencing technologies uncovered widespread RNA modifications on coding and non-coding RNAs collectively refer to as the epitranscriptome. However, we are only now starting to appreciate the impact of the epitranscriptome in regulating cell biology. Among more than 150 RNA modifications, I focused on pseudouridine (Ψ) the most abundant single-nucleoside RNA modi
Infectious diseases that can be transmitted via air often spread rapidly, sometimes causing large epidemic and pandemic outbreaks. As an increasing number of people live in crowded urban environments, and with frequent and long-distance traveling across the world, infectious diseases can spread even faster. Yet, our knowledge of how much airborne transmission (here defined as aerosol particles <10
The ability of new neurons to promote repair of brain circuitry depends on their capacity to re-establish afferent and efferent connections with the host. In this review article, we give an overview of past and current efforts to restore damaged connectivity in the adult mammalian brain using implants of fetal neuroblasts or stem cell-derived neuronal precursors, with a focus on strategies aimed t
