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The purpose of this study was to explore and compare different countries in what motivated research participants’ decisions whether to share their de-identified data. We investigated European DIRECT (Diabetes Research on Patient Stratification) research project participants’ desire for control over sharing different types of their de-identified data, and with who data could be shared in the future

Many genetic loci affect circulating lipid levels, but it remains unknown whether lifestyle factors, such as physical activity, modify these genetic effects. To identify lipid loci interacting with physical activity, we performed genome-wide analyses of circulating HDL cholesterol, LDL cholesterol, and triglyceride levels in up to 120,979 individuals of European, African, Asian, Hispanic, and Braz

Objective: (1) To estimate the life-time genetic contribution for knee osteoarthritis (OA) surgery and (2) to explore any differences in the genetic contribution across age, sex and body mass index (BMI). Methods: We studied the sex-specific genetic contribution to knee OA surgery in a prospective cohort study of 62,490 twins aged 35 years or older with a follow-up period of up to 47 years (10,092

Med hjälp av ett automatiserat mätsystem för partikelhalter i vatten har vattenkvaliteten vid Borensbergs vattenverk i Motala kommun undersökts under ett års tid med avseende på mikroskopiska partiklar i dricksvatten och råvatten. Antalet mikroskopiska partiklar registrerades som absoluta värden i realtid. I denna artikel diskuteras hur larmgränser skall definieras i praktiken för partikelhalter oDuring a one year long research project at Borensberg Waterworks, Motala, Sweden, water quality with respect to microscopic particle counts both in raw water and drinking water have been monitored by an online water quality monitoring system. Microscopic particle counts were documented with absolute values in real-time. In this paper, a discussion is introduced on how to analyze large data sets fr

In genotype-based recall (GBR) studies, people (or their biological samples) who carry genotypes of special interest for a given hypothesis test are recalled from a larger cohort (or biobank) for more detailed investigations. There are several GBR study designs that offer a range of powerful options to elucidate (1) genotype-phenotype associations (by increasing the efficiency of genetic associati

Buildings are responsible for a third of global greenhouse gas emissions, with much of their life cycle impacts stemming from embodied impacts of building materials. Both at EU and Member State level, circular economy and resource efficiency policies are promoting production of lower-impact building materials with secondary material input. However, secondary material strategies do not result in ca

Development in building envelopes and energy efficient systems has an impact in reducing energy use, but the everyday life of the households significantly influences the total performance of the housing sector that in Sweden constitutes 25% of the total energy use. This paper presents and discusses some results of a study investigating the relationship between every-day life and energy use among t

Behandlar gipsavgjutningarnas ställning och roll i konstutbildningen och på konstmuseerna från 1700-talet till 1914.

Aims: Subclinical systemic inflammation may contribute to the development of type 2 diabetes, but its association with early progression of glycaemic deterioration in persons without diabetes has not been fully investigated. Our primary aim was to assess longitudinal associations of changes in pro-inflammatory (leukocytes, high-sensitivity C-reactive protein (hsCRP)) and anti-inflammatory (adipone

The detailed characterization of human biology and behaviors is now possible at scale owing to innovations in biomarkers, bioimaging, and wearable technologies; "big data" from electronic medical records, health insurance databases, and other platforms becoming increasingly accessible; and rapidly evolving computational power and bioinformatics methods. Collectively, these advances are creating un

The present paper deals with the time - dependent rock deformation during tunnelling, and more particularly, its association with the related phenomenon of creep in its viscoelastic form, as well as the numerical evaluation of it. Initially, a brief introduction of these two phenomena is provided. Then, the Burgers' idealized model of rheological rock mass behaviour is presented and analysed, alon

Aims: In this research we assessed the prevalence of prediabetes and type 2 diabetes and its association with social determinants such as indigenous origin and residence area in population from Comitan, Chiapas, Mexico. Methods: The Comitan Study is a population-based study carried out from 2010 to 2012 that included 1844 participants aged ≥ 20 years, 880 indigenous and 964 nonindigenous participa

A case of acute hepatitis due to hepatitis E virus genotype 3 was diagnosed by serology and genomic sequencing. Phylogenetic analysis demonstrated a strain identical to one isolated from a Swedish pig, which supports the hypothesis that swine serves as reservoirs for HEV infection. The patient did not have any recent travel history, had experienced no contact with animals and the origin of the inf

The concentrations of high- and low-density-lipoprotein cholesterol and triglycerides are influenced by smoking, but it is unknown whether genetic associations with lipids may be modified by smoking. We conducted a multi-ancestry genome-wide gene–smoking interaction study in 133,805 individuals with follow-up in an additional 253,467 individuals. Combined meta-analyses identified 13 new loci assoc

BACKGROUND: Gout is the most common inflammatory arthritis with a rising prevalence around the globe. While educational inequalities in incidence and prevalence of gout have been reported, no previous study investigated educational inequality in mortality among people with gout. The aim of this study was to assess absolute and relative educational inequalities in all-cause and cause-specific morta

Under efterkrigstiden skakades Stockholm återkommande av så kallade ungdomsupplopp, som av samtidens makthavare förstods som opolitiska, ja näst intill meningslösa i sin obegriplighet. Samtidigt låter händelserna oss resonera kring förhållandet mellan det offentliga rummet och människors kollektiva aktörskap. Genom att närma sig upploppen utifrån den politiska filosofen Jacques Rancières teorier o