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Fluid transport in the perivascular space by the glia-lymphatic (glymphatic) system is important for the removal of solutes from the brain parenchyma, including peptides such as amyloid-beta which are implicated in the pathogenesis of Alzheimer’s disease. The glymphatic system is highly active in the sleep state and under the influence of certain of anaesthetics, while it is suppressed in the awak
Abstract: Ceramic matrix composites based on cubic boron nitride with a TaC binder phase are sintered under conditions of high pressure and high temperature. The sintering is carried out in a high-pressure apparatus of the toroid type in the temperature range of 1450–2450°C. It is shown that a chemical reaction between components of the mixture with the formation of TaB2 takes place at a sintering
Investigations of social-genetic effects, whereby a social partner’s genotype affects another’s outcomes, can be confounded by the influence of the social partner’s rearing environment. We used marital information on more than 300,000 couples from Swedish national data to disentangle social-genetic from rearing-environment effects for alcohol use disorder (AUD). Using observational and extended-fa
The transition to a resource efficient economy that makes effective use of raw materials and energy is a multi-level dynamic process requiring a wide systems perspective. To operationalize this transition in a holistic manner, the concept of Circular Economy (CE) has been championed by major economies around the world. The idea with CE is to strive towards maximizing the utilization of products, c
Societal safety and sustainability are key challenges in our complex and dynamic world, causing growth in interest of applying the concept of resilience in broader societal contexts. This chapter presents a concept of societal resilience that builds on established theory of Resilience Engineering and operationalises the concept by presenting its purpose, required functions and a way to identify an
This data article presents water stage, flow, and net primary productivity (NPP) data that were used to analyze the dynamics of the riverine dissolved organic carbon (DOC) dynamics in the Rukarara River watershed in Rwanda. We measured water stage data every 15 min and calculated daily averages used to estimate flow based on rating curves. The rating curves were produced using several measured con
Semiconductor nanowires can act as nanoscaled optical fibers, enabling them to guide and concentrate light emitted by surface-bound fluorophores, potentially enhancing the sensitivity of optical biosensing. While parameters such as the nanowire geometry and the fluorophore wavelength can be expected to strongly influence this lightguiding effect, no detailed description of their effect on in-coupl
OBJECTIVES: To simplify the previously published Nottingham 12-year risk prediction model for knee osteoarthritis (OA) and examine whether it can be used to predict the 40-year risk of knee OA in young men.METHODS: We included 40 118 men aged 18 undergoing military conscription in Sweden 1969-70. Diagnostic OA codes were obtained from the Swedish National Patient Register 1987-2010. The original N
Background: Novel efficacious treatments with long-term tolerability are needed for transplant-ineligible, newly diagnosed multiple myeloma (NDMM) patients. This phase 2 study evaluated the safety and efficacy of all-oral ixazomib-cyclophosphamide-dexamethasone (ICd) followed by single-agent ixazomib maintenance. Patients and methods: Patients were randomised (1:1) to receive 4.0 mg of ixazomib, 3
Background. Regular exercise reduces pulse rate, but it is less clear how prolonged sitting time affects pulse rate. Our hypothesis was that high physical activity could compensate for prolonged sitting time regarding the pulse rate. Methods. Regression analysis was performed on cross-sectional data including 47,457 men and women based on two Swedish cohort studies, EpiHealth (18–45 years) and Lif
Many studies suggest that increased exposure to urban greenness is associated with better population health. Accessing nature can in some circumstances, however, be difficult, especially for individuals with mobility constraints. Therefore, a growing body of work is investigating the ways to replace the in vivo experience with forms of “virtual” contact, in order to provide these individuals with
Due to increased urbanisation, and climate change, there have been calls for a more sustainable management of stormwater. Blue-green measures have been recognised as a sustainable solution and a necessary complement to pipe-bound approaches. The aim of this study is to identify barriers and drivers in the implementation of blue-green measures in a Swedish context, to increase the understanding of
Purpose: The impact of androgen receptor (AR) activity Results: D-Norgestrel and DHT activated the AR pathway, in breast cancer biology is unclear. We characterized and while 17b-Estradiol did not. Competitive binding for AR tested a novel therapy to an AR-governed target in breast protein showed similar affinity between DHT and D-Norges-cancer. trel, indicating direct AR–ligand interaction. In vi
Molecular motor-based nanodevices require organized cytoskeletal filament guiding along motility-promoting tracks, confined by motility-inhibiting walls. One way to enhance motility quality on the tracks, particularly in terms of filament velocity but also the fraction of motile filaments, is to optimize the surface hydrophobicity. We have investigated the potential to achieve this for the actin-m
This European Randomized study of Screening for Prostate Cancer trial follow-up reports that repeated screening reduces the risk of dying from prostate cancer for up to 16 yr.
Nanowire (NW) based devices provide bright possibilities for many different applications [1]. The use of block copolymers (BCPs) for nanopatterning of dielectric masks for selective area metal-organic vapor phase epitaxy (MOVPE) of III-V nanowires [2] and for NW-device applications [3] has a great potential, when it comes to increasing the NW density and reducing their diameters, which is importan
The shell condenser is a key component for the underwater vehicles. To study its heat transfer performance and flow characteristics and to design a more efficient structure, a mathematical model is generated to simulate condensation inside the straight and helical channels. The model combines empirical correlations and MATLAB based on an it
