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Type 2 diabetes mellitus (T2DM) and HER2 are associated with cancer although the role of HER2 in T2DM is not well defined. Our aim was to investigate the association between HER2 levels and T2DM and whether that association was different in Swedish people born in Iraq or Sweden.
This master’s thesis explores the design of a construction toy that supports developmental play for children aged seven to ten years. The project is motivated by the observation that increasing digitalization and highly stimulating environments are changing the way children play, potentially reducing opportunities for tactile, open-ended, and self-directed play experiences that contribute to healt
The studies described in this thesis forms part of a larger collaborative project, Neonuclei, with the objective to design a module for packaging the negatively charged DNA into a ”neonucleus” with transcription competence. There are many applications that require control of DNA compaction, i.e. packaging or condensation. One example is the systemic delivery of DNA for gene therapy. In this work,
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We present a framework for computing optimal transformations, aligning one point set to another, in the presence of outliers. Example applications include shape matching and registration (using, for example, similarity, affine or projective transformations) as well as multiview reconstruction problems (triangulation, camera pose etc.). While standard methods like RANSAC essentially use heuristics
Dyslexia is a problem that can limit someone’s life if the person does not receive the appropriate support in order to develop strategies to deal with it, and it is not limited to one’s first language. The first limitations appear early in life during the school years as the child struggles with literacy issues. It is in the educational environment where the child will receive the first support a
As a food processing lines manufacturer with diverse product complexity, an understanding of fluid dynamics in a pipe system corresponding to the rheological properties and flow behavior is substantial. This will be beneficial to design suitable equipment and prevent processing-related issues, i.e. lowering filling performance, over-dimensioning pumps, excess energy consumption, etc. Therefore, th
The aim of this Master’s thesis project was to investigate whether it would be possible to simulate, using either Boundary Element Method (BEM) or Lumped Element Method (LEM) modelling, how microphone port design impacts an embedded microphone’s ability to capture sound accurately. The project utilized Design of Experiments (DoE) methodology. Key design parameters impacting the performance of an
Background Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental condition influenced by both genetic and environmental factors. Prenatal and perinatal exposures have been implicated in ASD etiology, but their influence may vary across clinical subgroups, including subgroups defined by co-occurring intellectual disability (ID). Methods We conducted a population-based case–control st
A string of speech is a string of syllables, a series of varying amounts of jaw openings/closings. Neutralizing the vowel-intrinsic jaw opening indicates a pattern of jaw opening matching the utterance syllable prominence patterns. The hypothesis is that the jaw-opening patterns ensue from the metrical hierarchy of the language, such that for languages such as English, we see exponentially increas
Mentoring graduate students and postdoctoral researchers shapes the development of future scientists and, by extension, the progress of science itself. Here we explain how scientific mentoring can be enhanced by incorporating history and philosophy of science (HPS). HPS can provide mentees with a vocabulary for interpreting scientific practice and help to foster creative and innovative biologists
Title Breaking down functional silos with Sales and Operational Planning: A case study at a Swedish grocery wholesaler Authors Tim Engrenius and Emma Rydén Supervisor Dag Näslund - Senior Lecturer at Division of Engineering Logistics, Faculty of Engineering at Lund University Examinator Jan Olhager - Professor at Division of Engineering Logistics, Faculty of Engineering at Lund University Problem
Interactions between antioxidant-impregnated low-density polyethylene (LDPE) and polypropylene (PP), and oxygen-sensitive foods have been investigated. BHT and a-tocopherol are two antioxidants commonly used in both foods and polymers. In general, BHT was rapidly lost from LDPE film in contact with various foodstuffs. a-Tocopherol was completely retained in PP film, but some losses, although less
One of the most promising and novel strategies to interfere with neurological disease processes is gene therapy using recombinant adeno-associated viral (rAAV) vectors. Such a rAAV-based gene delivery approach is rapidly advancing towards clinical trials. In this regard, neuropeptide Y (NPY) gene transduction into the brain tissue has attracted particular interest due to its potential to regulate
Popular Abstract in Swedish Streptococcus pyogenes Människan är ständigt koloniserad av en mängd olika mikroorganismer. De flesta bakterier är ofarliga och en del av dem är faktiskt nödvändiga för oss, t.ex. de tarmbakterier som hjälper oss att producera vitaminer. Grupp A streptokocker (GAS) eller Streptococcus pyogenes, är en av de vanligaste sjukdomsframkallande bakterierna hos människan. De kaWe have found that a set of group A streptococcal strains, primarily associated with skin infections, express surface-associated M proteins that bind plasminogen and plasmin with high affinity. The binding is mediated by a common 13 amino acid internal repeated sequence located in the NH2-terminal surface-exposed portion of these M proteins. It could be demonstrated that plasminogen, absorbed by t
Lightweight walls and floors are often designed as frameworks of studs with plates on each side - a double-plate structure. The free wave-modes and periodic wave motion of a double-plate system reinforced by joists are analysed in the present paper (as the insertion loss and impact sound insulation have been studied in previous papers). The free wave-modes can in a future step be used in connectio
This chapter describes a personal aerosol sampler with size fractionation and time resolution that gives samples for elemental analysis. An impaction stage collects coarse particles and a filtration stage collects finer ones. Sampling in consecutive time intervals is performed on different impaction and filtration surfaces. These sampling surfaces corresponding, for example, to 15-min intervals, m
This paper describes some exploratory attempts to apply a combination of finite state transducers (FST) and transformation-based learning (TBL, Brill 1992) to the problem of letter-to-sound (LTS) conversion for Swedish. Following Bouma (2000) for Dutch, we employ FST for segmentation of the textual input into groups of letters and a first transcription stage; we feed the output of this step into a
