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Genetic studies of complex traits have become increasingly successful as progress is made in next-generation sequencing. We aimed at discovering single nucleotide variation present in known and new candidate genes for developmental dyslexia: CYP19A1, DCDC2, DIP2A, DYX1C1, GCFC2 (also known as C2orf3), KIAA0319, MRPL19, PCNT, PRMT2, ROBO1 and S100B. We used next-generation sequencing to identify si
A method for form finding with dynamic relaxation and Non-Uniform Rational B-Splines (NURBS) based isogeometric membrane elements has been implemented and studied regarding the influence of the discretization and element shape on the form finding. The procedure allows for rapid form finding since NURBS describe the curved geometry well and it is shown that the form-finding can be performed using a
In 1996 the European Union adopted the Seveso II Directive. The Directive stated actions to be taken in the process industry in order to prevent and limit the impact of serious chemical accidents. In the Directive it is clearly stated that domino effects shall be considered, but the level of detail required is not specified. Due to that fact and the high degree of complexity linked to domino e
The aim of this thesis is to analyze large datasets with mathematical modeling and frequency analysis. The models used were polynomials and trigonometric polynomials. These were applied on a sample dataset with 377 data points. Another dataset with approximately 2.6 million data points was also tested with a model of first degree polynomial and trigonometric polynomials with different number of do
Purpose: The purpose of this paper was to explore how the companies which have prioritized sustainability on their business agenda have designed their management control systems (MCSs) to support sustainability-driven innovation and if and how these companies are using the sustainability metrics internally within their cybernetic control systems. In order to do so, an additional purpose of our the
This thesis focuses on the affective and emotional dimensions of Turkish women’s engagement with #sendeanlat, an online protest against sexism and sexual harassment in Turkey. The thesis sets out to explore the affective and emotional characteristics of the women’s engagement and the awareness generated through this engagement. By applying a qualitative approach, 14 semi-structured interviews were
Powders are complex systems that depend strongly on how the individual particles in- teract and their surroundings. Understanding powders behaviour under certain conditions is very important for the product in many applications, one of them being Additive Manu- facturing (AM). The overall goal of this study is to understand and quantify the effect of flow additives in combination with iron powder.
The use of machine learning as a tool in medicine is increasing and has provided new avenues for research into a number of diseases. Creating better predictive models for these diseases could provide opportunities for better care, which we have applied to osteoarthritis, a degenerative disease that affects a large part of the older population. We have sought to answer ``Is it possible to predict
Title Breaking down functional silos with Sales and Operational Planning: A case study at a Swedish grocery wholesaler Authors Tim Engrenius and Emma Rydén Supervisor Dag Näslund - Senior Lecturer at Division of Engineering Logistics, Faculty of Engineering at Lund University Examinator Jan Olhager - Professor at Division of Engineering Logistics, Faculty of Engineering at Lund University Problem
Dyslexia is a problem that can limit someone’s life if the person does not receive the appropriate support in order to develop strategies to deal with it, and it is not limited to one’s first language. The first limitations appear early in life during the school years as the child struggles with literacy issues. It is in the educational environment where the child will receive the first support a
Finding work for people with severe physical disabilities is not easy. This master thesis aims to investigate the possibility of creating new job opportunities for these people, using speech recognition. One possibility is to construct an application where a person works in a callcentre by using his/her voice. To test the idea a co-operation with the callcentre at Trygg Hansa in Malmö was initiate
As a food processing lines manufacturer with diverse product complexity, an understanding of fluid dynamics in a pipe system corresponding to the rheological properties and flow behavior is substantial. This will be beneficial to design suitable equipment and prevent processing-related issues, i.e. lowering filling performance, over-dimensioning pumps, excess energy consumption, etc. Therefore, th
The climate crisis is not only affecting the physical world, but individuals’ mental health. The concept of ecoanxiety has reached major attention in the public discourse and more individuals report psychological consequences as a result of climate change. The call for action is urgent, but what are individuals doing to prevent further harm to the planet? Does the experience of ecoanxiety leave th
After diagnosis of craniopharyngioma, patients frequently develop a rapid weight gain leading to morbid hypothalamic obesity due to disease- and/or treatment-associated hypothalamic lesions. Hypothalamic obesity should be diagnosed and treated in the context of hypothalamic syndrome. Hypothalamic syndrome includes neuroendocrine deficiencies, disruption of circadian rhythm, disturbed hunger-satiet
Quantum instruments describe both the classical outcome and the updated state associated with a quantum measurement. We ask whether these processes can be simulated using only a natural subset of resources, namely projective measurements on the system and quantum processing of the postmeasurement states. We show that the simulability of instruments can be connected to an entanglement classificatio
The automotive industry is in for significant changes in the years to come. With the acknowledgment of greenhouse gases as a major contribution to global temperature rise, energy usage sees a transition in favor of renewable sources. Adding the uncertainty of whether a peak-oil production is reached or not, fossil fuels are no longer considered reliable. In the wake of this, new candidates emerge
This Master Thesis was made under and in collaboration with Pond Healthcare Innovation for Celgene. Celgene is a global pharmaceutical company developing treatments for cancer and other severe, immune, inflammatory conditions. In March 2015 Celgene launched a new oral treatment called Otezla (effective substance aprimelast) on the Nordic market. With this move they entered the arena of Psoriasis a
