Filtyp
This master’s thesis explores the design of a construction toy that supports developmental play for children aged seven to ten years. The project is motivated by the observation that increasing digitalization and highly stimulating environments are changing the way children play, potentially reducing opportunities for tactile, open-ended, and self-directed play experiences that contribute to healt
A search for new phenomena in events with a high-energy jet and large missing transverse momentum is performed using data from proton-proton collisions at root s = 7 TeV with the ATLAS experiment at the Large flatiron Collider. Four kinematic regions are explored using a dataset corresponding to an integrated luminosity of 4.7 fb(-1). No excess of events beyond expectations from Standard Model pro
Objectives The purpose of this study is investigate the effects of variants in the apolipoprotein(a) gene (LPA) on vascular diseases with different atherosclerotic and thrombotic components. Background It is unclear whether the LPA variants rs10455872 and rs3798220, which correlate with lipoprotein(a) levels and coronary artery disease (CAD), confer susceptibility predominantly via atherosclerosis
Dementia with Lewy Bodies (DLB) is a common neurodegenerative disorder with poor prognosis and mainly unknown pathophysiology. Heritability estimates exceed 30% but few genetic risk variants have been identified. Here we investigated common genetic variants associated with DLB in a large European multisite sample. We performed a genome wide
Measurements of the branching ratios of top quark decays into leptons and jets using events with t (t) over bar ( top antitop) pairs are reported. Events were recorded with the ATLAS detector at the LHC in pp collisions at a center-of-mass energy of 7 TeV. The collected data sample corresponds to an integrated luminosity of 4.6 fb(-1). The measured top quark branching ratios agree with the Standar
At the beginning of the 21st Century, Zen Buddhism is no longer an unknown religion in the West. Zen-meditation enjoys great popularity, the books regarding the subject are among the bestsellers and the auditoriums are crowed if the topic concerns the bringing home of Zen Buddhism to a Western audience. At the same time Zen Buddhism today is by no means merely the religion of Zen Buddhists, but pr
Sammanfattning Bakgrund: Interventioner med mindfulnessmeditation har under 2000-talet etablerats som en behandlingsform i västerländsk vård. Behandlingsformen grundlades 1979 av den biomedicinska forskaren Jon Kabat- Zinn, som inom en experimentell studie behandlade patienter med kronisk smärta med ett meditationsbehandlingsprogram. Mindfulnessinterventioner är en syntes av buddhistisk meditation
Twenty-nine rats were subjected to a severe standardized hepatic injury and divided into four groups. In addition to controls, the animals were treated with PASG inflated to 40 mm Hg, PASG and infusion of Ringer's acetate, or PASG and infusion of Ringer's acetate and Dextran 70 in combination. The aim of the infusion therapy was to stabilize the mean aortic blood pressure at 60 mm Hg. PASG signifi
The work is composed of three parts: - (1) An overview of the concept moisture deign with regard to service life. (this report) - (2) A practical application of service life analysis applied to frost damage, based on materials testing. (this report) - (3) A theroretical analysis of methods for service life design of concrete and concrete structures exposed to internal frost damage (Report TVBM-04/
Background: Existing studies of solid cancers in rheumatoid arthritis ( RA) reflect cancer morbidity up until the early 1990s in prevalent cohorts admitted to hospital during the 1980s. Objective: To depict the cancer pattern of contemporary patients with RA, from updated risk data from prevalent and incident RA populations. To understand the risk of solid cancer after tumour necrosis factor (TNF)
We report the weight, stature, body mass index (BMI), and muscular strength of men about 19 years old who have cleft lip, either with or without cleft palate (CLP), or cleft palate only (CP). Data were obtained from the Swedish National Service enrolment register for the years 1991 - 97, and concerned 335 men with CLP and 88 with CP, who were compared with a control group of 272 879 men. The data
Background and aims Metabolic syndrome has been reported to have adverse effects on cognition although the results are conflicting. We investigated the association between metabolic syndrome and cognitive function in a population sample of middle-aged and older European men and whether any observed association could be explained by lifestyle or other confounding factors. Methods A total of 3369 me
Although subjects with inherited defects of the classical complement pathway component C2 are at increased risk of infection, there are few experimental data available on which bacterial pathogens they might be susceptible to. In order to investigate whether patients with inherited C2 deficiency may have increased susceptibility to Streptococcus pyogenes infection we have analysed opsonization wit
Levothyroxine has been suggested to be cardiotoxic, but previous studies on the risk of cardiovascular events associated with levothyroxine treatment have been inconclusive. We aimed to study the association between levothyroxine treatment and all-cause mortality as well as cardiovascular events. Study population included all adults (n = 12,283) ≥ 45 years diagnosed with atrial fibrillation (AF) a
Background: Carbohydrate antigen 125 (CA125) is a mucin produced by serosal cells in response to mechanical and inflammatory stimuli. CA125 has emerged as prognostic biomarker in heart failure (HF) and correlates with markers of fluid overload, echocardiographic parameters and prognosis in HF patients. In patients with acute coronary syndrome (ACS), elevated CA125 is correlated with a higher risk
Background Worse outcomes have been noted in patients with multiple primary melanomas (MPMs) than in patients with single primary melanomas. Objective We investigated how family history of melanoma and germline CDKN2A mutation status of MPM patients affects risks of developing subsequent melanomas and other cancers and survival outcomes. Methods Comprehensive data on cancer diagnoses and deaths of
Diamond-Blackfan anemia (DBA) is a congenital erythroid hypoplasia caused by a functional haploinsufficiency of genes encoding for ribosomal proteins. Among these genes, ribosomal protein S19 (RPS19) is mutated most frequently. Generation of animal models for diseases like DBA is challenging since the phenotype is highly dependent on the level of RPS19 downregulation. We report the generation of m
