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Background: Cholecystokinin (CCK) concentrations in plasma have been shown to be significantly higher in colectomised subjects compared to healthy controls. This has been ascribed to reduced inhibition of CCK release from colon. In an earlier study CCK in all but one woman who was colectomised, induced release of oxytocin, a peptide present throughout the gastrointestinal (GI) tract. The aim of th
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A 76-year-old man presented with cognitive symptoms, followed by headache and weakness of the lower limbs and left arm. The clinical course was progressive but fluctuating. On magnetic resonance imaging (MRI), a contrast-enhancing lesion 1 cm in diameter was seen in the left temporal lobe. This lesion became attenuated and a new contrast-enhancing lesion 1 x 2 cm was seen in the left frontal lobe
Rapid development of new microscopy techniques exposed the need for genetically encoded fluorescent tags with special properties. Recent works demonstrated the potential of fluorescent proteins with tryptophan-based chromophores. We applied rational design and random mutagenesis to the monomeric red fluorescent protein FusionRed and found two groups of mutants carrying a tryptophan-based chromopho
PhenCode (Phenotypes for ENCODE; http://www.bx.psu.edu/phencode) is a collaborative, exploratory project to help understand phenotypes of human mutations in the context of sequence and functional data from genome projects. Currently, it connects human phenotype and clinical data in various locus-specific databases (LSDBs) with data on genome sequences, evolutionary history, and function from the E
Rubrics and oral feedback are approaches to help students improve performance and meet learning outcomes. However, their effect on the actual improvement achieved is inconclusive. This paper evaluates the effect of rubrics and oral feedback on student learning outcomes. An experiment was conducted in a software engineering course on requirements engineering, using the two approaches in course assi
Abstract A promising approach in sepsis therapy is the use of peptides truncated from serum- and membrane-proteins with binding domains for LPS: antimicrobial peptides (AMPs). AMPs can be useful in combination with conventional antibiotics to increase killing and neutralize LPS. Although many AMPs show a high specificity towards bacterial membranes, they can also exhibit toxicity, i.e. non-specifi
Bacteria that enter the bloodstream will encounter components of the cellular and soluble immune response. Platelets contribute to this response and have emerged as an important target for bacterial pathogens. Bacteria produce diverse extracellular proteins and toxins that have been reported to modulate platelet function. These interactions can result in complete or incomplete platelet activation
User generated data is getting more and more common. This data often expands in to hundreds of millions, if not billions, of data points. It is in the interest of every company with these vast amounts of data to make sense of them in one way or another. In machine learning, cluster analysis has been one way of trying to categorize data without supervision. Mahout is a library which runs on top of
In this thesis optimization methods for image segmentation are studied. The common theme of all the methods is that we have a histogram model for appearance terms that we optimize jointly with smoothness. Recently it has been shown that if one assumes a histogram model for appearance, it is possible to optimize an approximation of the energy using only one graph cut, by ignoring the non-submodular
This study aims to get a better understanding of what obstacles and problems organizations face when working with Open Innovation what solutions they then employ.
This project discusses the effects of recycle streams on the dynamics and performance of chemical plants. The questions addressed are: can the current industry standard tuning methods still be applied to systems with recycle, and if not, how can they be modified? This is approached by analysing the arrest time tuning method when applied to an integrating process with and without recycle. The resul
In robotic systems, uncertainty in model parameters, such as joint stiffness, link lengths, or mass distributions, can significantly affect performance and precision. This thesis investigates the quantification and propagation of such uncertainties using the programming language Julia, with a focus on developing a systematic framework for uncertainty-aware modeling and simulation. It leverages the
There is a significant risk that the current pro-environmental efforts embedded in the prevailing paradigm (shallow ecology) will not be sufficient to solve the increasing number, severity and urgency of environmental/societal challenges – at least they appear to be unable to solve the problems in time. Through literature review and case studies, this thesis author explores how humans having direc
Background: Malignant melanoma and non-melanoma skin cancers are among the fastest increasing malignancies in many countries. With the help of new tools, such as teledermoscopy referrals between primary health care and dermatology clinics, the management of these patients could be made more efficient. Objective: To evaluate the diagnostic agreement and interobserver concordance achieved when asses
Several interactions of cytokines with extracellular matrix molecules are mediated by proteoglycans, such as biglycan and decorin. Using surface plasmon resonance, we show for the first time that tumour necrosis factor-alpha (TNF-alpha) binds to both biglycan and decorin with K(d)s of 0.81 microM and 1.23 microM respectively, a binding that was confirmed by Scatchard plots using a solid phase assa
A cochlear implant (CI) is a device that provides individuals with severe to profound hearing impairment (SPHI) with auditory stimulation, which makes it possible for them to develop skills related to spoken communication. We have little knowledge about how hearing with a CI influences cognitive and communicative development and there is a need for development of methods for assessment. The genera
We study Markov interval maps with random holes. The holes are not necessarily elements of the Markov partition. Under a suitable, and physically relevant, assumption on the noise, we show that the transfer operator associated with the random open system can be reduced to a transfer operator associated with the closed deterministic system. Exploiting this fact, we show that the random open system
