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A complex of chagasin, a protein inhibitor from Trypanosoma cruzi, and papain, a classic family C1 cysteine protease, has been crystallized. Kinetic studies revealed that inactivation of papain by chagasin is very fast (k(on) = 1.5 x 10(6) m(-1).s(-1)), and results in the formation of a very tight, reversible complex (K-i = 36 pm), with similar or better rate and equilibrium constants than those f
In an analytical-method comparison study of clinical samples, the Abbott RealTime CT new formulation assay (m2000 real-time PCR), consisting of a duplex PCR targeting different parts of the cryptic plasmid in Chlamydia trachomatis, was compared both with version 2 of the Roche Cobas TaqMan CT assay, comprising a duplex PCR for a target in the cryptic plasmid and the omp1 gene, and with the Gen-Pro
There is a lack of validated autism-specific outcome measures for large-scale evaluation of the effectiveness of psycho-educational programmes. To fill this gap the Environment Rating Scale (ERS) was adapted from an interview version to a staff-completed questionnaire version (ERS-Q). The ERS-Q was tested regarding data quality, validity, reliability and ease of understanding amongst 18 residentia
Migratory birds use multiple compass systems for orientation, including a magnetic, star and sun/polarized light compass. To keep these compasses in register, birds have to regularly update them with respect to a common reference. However, cue-conflict studies have revealed contradictory results on the compass hierarchy, favoring either celestial or magnetic compass cues as the primary calibration
Abnormalities in blood inflammatory markers have been associated with clinical manifestations and the pathogenesis of the fibromyalgia syndrome (FMS); a relationship between inherited alpha1-antitrypsin deficiency (AATD) and FMS has also been recently raised. In this study, plasma levels of inflammatory markers in FMS patients with and without AATD have been investigated. Blood samples from 138 ag
There is a need to improve the prognostic and predictive indicators in non-small cell lung cancer (NSCLC). At present, the main focus is on genetic predictive markers while the prognostic value of the standard blood variables related to haematopoiesis has been subjected to relatively limited attention. To study the prognostic potential of haemoglobin (Hgb), platelet (Plt) and white blood cell (WBC
Vikings routinely crossed the North Atlantic without amagnetic compass and left their mark on lands as far away as Greenland, Newfoundland and Baffin Island. Based on an eleventh-century dial fragment artefact, found at Uunartoq in Greenland, it is widely accepted that they sailed along chosen latitudes using primitive Sun compasses. Such instruments were tested on sea and proved to be efficient h
In the hospital, intensive care unit (ICU) is an isolated space where patients with acute symptoms are treated. When the patients are in ICU, their families are usually in psychological crisis and under great pressure. The value of ICU is thus to provide a complete ICU service by which not only the patients receive good treatment, but the feelings of family members are also considered and managed.
In The Girl with the Dragon Tattoo, Stieg Larsson depicts a fiery, independent and highly sexual protagonist in the character of Lisbeth Salander. While many readers fail to notice the subtle reference to Lisbeth’s natural red hair, this quality, along with Larsson’s admittance that his inspiration originated from Astrid Lindgren’s Pippi Longstocking, situates Lisbeth in a long tradition of redhea
The aim of this qualitative field study was to investigate and analyse Samburu men’s perspective on Female Genital Mutilation/Cutting (FGM/C) in Samburu, Kenya. The chosen subjects to examine were the men’s perspective of the practice of FGM/C itself, the process of change of mind and their involvement in ending FGM/C. To achieve this aim, in-depth interviews were made with 10 men in the surroundi
One of the target goals for sustainable development is the reduction of maternal mortality, which is a big health issue in some countries. Even if the research on maternal health care has come far and with the right expertise and supplies, almost all maternal deaths would be preventable. A working force to reduce the issues within maternal mortality in many countries are non-governmental organizat
This paper aims at assessing the economic features and the environmental impact of a wooden tower used in wind-solar renewable energy generating systems. The life cycle assessment method and return on investment method were used in order to achieve the objectives of the study. Two types of towers were used in the analysis: an impregnated wooden tower and an untreated one. Besides wood, the tower i
This thesis project aims to research the opportunities and challenges of development projects that integrate climate change adaptation (CCA) with youth empowerment in the rural community of Rangtse, Haa Dzongkhag in Bhutan. A vulnerability assessment was conducted by analyzing the exposure, sensitivity, and resilience of the Rangtse area to climate change through the dimensions of Gross National H
German forests are in a deteriorating state. The effects of climate change are increasingly showing and presenting society, and also forest owners, with the challenge of restructuring forests to become more climate resilient. At the same time there is a need to halt forest biodiversity loss and to further provide renewable resources that can be used to decarbonise its economy. At present forests’
Background: Cancer, which is known for its high mortality rate, can affect several tissue types. Among these, breast cancer is the most prevalent form worldwide and gliomas has one of the highest mortality rates among all cancer types. CSMD1 is a complement inhibitor with known tumor suppressor properties, whose down-regulation and deletion has been identified in several cancer types. In this stud
Disaster response is most effective, if a high level of preparedness is in place before natural hazards strike. As many low-income countries are under-financed when it comes to Disaster Risk Reduction, it is lower-cost interventions such as Community-Based Preparedness Trainings that they often rely on to provide strategies to reduce the vulnerability of communities. These trainings are widely use
This master's thesis, in collaboration with Comsys AB, examines the optimal size of a Battery Energy Storage System (BESS) for two services - energy shifting and constant power delivery across the four price areas SE1, SE2, SE3, and SE4 in Sweden. For energy shifting applications, the optimal storage capacities were found to be 20 MWh (2 MWh/MW) in SE1, SE2, and SE4. However, a 0.5 MWh/MW stor
This master's thesis, in collaboration with Comsys AB, examines the optimal size of a Battery Energy Storage System (BESS) for two services - energy shifting and constant power delivery across the four price areas SE1, SE2, SE3, and SE4 in Sweden. For energy shifting applications, the optimal storage capacities were found to be 20 MWh (2 MWh/MW) in SE1, SE2, and SE4. However, a 0.5 MWh/MW stor
