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IgA nephropathy (IgAN) and Henoch-Schönlein purpura (HSP) are diseases characterized by IgA deposits in the kidney and/or skin. Both may arise after upper respiratory tract infections, but the pathogenic mechanisms governing these diseases remain unclear. Patients with IgAN (n = 16) and HSP (n = 17) were included in this study aimed at examining whether IgA-binding M proteins of group A streptococ
Complement C2 deficiency (C2D) is associated with immunological diseases and increased susceptibility to invasive infections caused by encapsulated bacteria such as Neisseria menigitidis. In this study we evaluate the immunogenicity of vaccination against N. menigitidis in C2D. C2D patients (n=22) and controls (n=52) were given a tetravalent meningococcal polysaccharide vaccine. Serum bactericidal
Transplantation of allogeneic embryonic neural tissue is a potential treatment for patients with Parkinson's and Huntington's diseases. The supply of human donor tissue is limited, and alternatives such as the use of animal (e.g., porcine) donor tissue are currently being evaluated. Before porcine grafts can be used clinically, strategies to prevent neural xenograft rejection must be developed. Kn
Objective. Antileukoproteinase (ALP) is a physiologic inhibitor of granulocytic serine proteases. The present study was undertaken to investigate its therapeutic benefit in an antibody-transfer model of erosive polyarthritis and to elucidate its potential to interfere with immune complex-dependent inflammatory pathways. Methods. Arthritis development was induced in male (BALB/c x B10.Q)F-1 mice by
Antimicrobial peptides (AMPs) are evolutionarily ancient molecules. They are essential innate immune response molecules that protect organisms from invading pathogens. Tissue factor pathway inhibitors (TFPI-1 and TFPI-2) C-terminal derived peptides exert host defense mechanisms against microbes. Studies showed that in human plasma, C-terminal TFPI-1 and -2 derived peptides mediate bacterial killin
Small synthetic ligands for protein purification have become increasingly interesting with the growing need for cheap chromatographic materials for protein purification and especially for the purification of monoclonal antibodies (mAbs). Today, Protein A-based chromatographic resins are the most commonly used capture step in mAb down stream processing; however, the use of Protein A chromatography
Of 30 bacterial species tested 18 stimulated DNA synthesis in human blood lymphocytes. The maximum response was after 3-4 days of culture suggesting a mitogenic effect. This was confirmed by the induction of polyclonal antibody production shown by a plaque assay. Most bacterial species increased the DNA synthesis in B-enriched lymphocytes and unseparated lymphocytes but had negligible activity on
Introduction: Recent haemophilia treatment advances include new recombinant FVIII (rFVIII) products with improved pharmacokinetic (PK) properties that aim to reduce the burden of prophylaxis. These treatments are commonly referred to as extended half-life rFVIII products (EHL rFVIII). There is no uniform definition of what constitutes an EHL rFVIII. Such a definition would help physicians, patient
Hu11B6 is a monoclonal antibody that internalizes in cells expressing androgen receptor (AR)-regulated prostate-specific enzyme human kallikrein-related peptidase 2 (hK2; KLK2). In multiple rodent models, Actinium-225-labeled hu11B6-IgG1 ([225Ac]hu11B6-IgG1) has shown promising treatment efficacy. In the present study, we investigated options to enhance and optimize [225Ac]hu11B6 treatment. First,
Tissue factor pathway inhibitor-2 (TFPI-2) has previously been characterized as an endogenous anticoagulant. TFPI-2 is expressed in the vast majority of cells, mainly secreted into the extracellular matrix. Recently we reported that EDC34, a C-terminal peptide derived from TFPI-2, exerts a broad antimicrobial activity. In the present study, we describe a previously unknown antimicrobial mode of ac
It has previously been shown that sera from multiparous women have increased levels of anti-idiotypic antibodies specific for anti-HLA molecules. γ-Globulins prepared from these sera may be superior to commercial preparations of intravenous γ-globulin (IVIg) for inhibiting HLA alloimmunization. To test this, F(ab′)2 fragments prepared from either commercial IVIg or from the sera of men or multipar
May 2022 Riktlinjer för stöd från NanoLund till internationella forskningsvistelser NanoLund önskar att stödja internationellt utbyte och inspirationsbesök i ledande internationella forskningsmiljöer. Pengar kan sökas närsomhelst under året från den exekutiva gruppen (ca 1 A4-sida). Resmål, resans längd och syfte med resan ska framgå. En budget för den förväntade totalkostnaden och sökt belopp är
https://www.nano.lu.se/sites/nano.lu.se/files/2022-05/NanoLund%20policy%20research%20visits.pdf - 2026-07-17
Arbetsrehabilitering Efterfrågan på evidensbaserade insatser har ökat markant i Sverige och Individual Placement and Support (IPS) är en av de högst prioriterade psykosociala insatserna i Socialstyrelsens nationella riktlinjer. Utbildningen har gått regelbundet sedan 2012 och fokuserar nu även på Supported Education. Särskild tonvikt i utbildningen kommer att läggas vid implementeringen av IPS i b
https://www.medicin.lu.se/sites/medicin.lu.se/files/uppdragsutbildning_ips_ht_2020.pdf - 2026-07-17
CRISPRideas TEMA 2019-2020 Utvecklingen av nya genredigeringstekniker som CRISPR-Cas9 har skapat en revolution inom biologisk och medicinsk forskning. De innebär möjligheter att göra precisa och riktade förändringar i arvsmassan på alla slags organismer, från mikroorganismer till människor. Inom växtförädlingen finns förhoppningar att kunna utveckla nya grödor som är bättre anpassade till ett fram
https://www.pi.lu.se/sites/pi.lu.se/files/2021-01/CRISPR%20SVE.pdf - 2026-07-17
Verksamhetsberättelse 2019 för EBSCO Systems Nordic User Group Vid EBSCO Systems Nordic User Groups årsmöte 2019-04-04 i Göteborg valdes följande styrelsemedlemmar: ordförande Cilla Öhnfeldt, Stockholms universitetsbibliotek (omval), Ellen Åberg, Chalmers bibliotek (nyval), Eva Sejmyr, Linköpings universitetsbibliotek (omval), Stellan Klint, Skånes universitetssjukhus bibliotek (omval), Linda Tryg
https://www.ub.lu.se/sites/ub.lu.se/files/verksamhetsberattelse_2019_for_ebsco_systems_nordic_user_group.pdf - 2026-07-17
EBSCO Systems Nordic User Group’s användardagar 3-4 april 2019 Lokal: Konferensrum Scrum 1, Chalmers huvudbibliotek, Johanneberg, Hörsalsvägen 2. Karta: https://goo.gl/maps/v7aWYPjpDfm Information om hur man hittar till Chalmers: http://www.lib.chalmers.se/vaara-bibliotek/hitta-hit/ Anmälan senast 27 mars 2019: https://goo.gl/forms/luIitQYeVUD1hH1D2 Onsdagen den 3 april (Representanter från EBSCO
https://www.ub.lu.se/sites/ub.lu.se/files/program_anvandardagarna_2019_ebsco_systems_nordic_user_group_002.pdf - 2026-07-17
Verksamhetsberättelse 2018 för EBSCO Systems Nordic User Group Vid EDS Nordic User Groups årsmöte 2018-03-15 i Malmö bestämdes det att föreningen skulle byta namn till EBSCO Systems Nordic User Group. Det nya namnet beskriver bättre föreningens syfte och att medlemmarna ska kunna lyfta frågor kring fler EBSCO-system än enbart EDS. Vid årsmötet valdes också följande styrelsemedlemmar: ordförande Ci
https://www.ub.lu.se/sites/ub.lu.se/files/verksamhetsberattelse_2018_for_ebsco_systems_nordic_user_group.pdf - 2026-07-17
