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Antipsychotic drugs (APD) are commonly prescribed to people living with dementia (PwD) to manage behavioral and psychological symptoms of dementia (BPSD), despite well-documented safety concerns. International guidelines recommend non-pharmacological interventions as first-line treatment, yet APDs remain widely used. This systematic review and meta-analysis synthesize current evidence on the conse
The fast development of generative artificial intelligence (“AI”) services—such as ChatGPT, Midjourney, Dall-E—have within a short period of time gained immense uptake and popularity. At the same time, such services have given rise to fundamental challenges from a copyright perspective. Court proceedings have been initiated in many jurisdictions on the compatibility of such services with copyright
This study explores the online communication strategies of anti-tourism movements to evaluate their potential contributions to place branding—a topic that has received limited scholarly attention. While prior research often views such movements as antagonistic to place branding efforts, we challenge this assumption. Through an analysis of nine movements across five countries, we apply the typology
Importance: Persistent disparities in mortality across countries suggest uneven improvements in living standards and access to life-extending health technologies, as well as context-specific obstacles. Studies have analyzed cross-country inequality in mortality but have not widely contextualized those disparities in terms of developmental progress relative to a frontier representing a level of mor
AIMS: Metformin has hitherto not been proven superior to other type 2 diabetes (T2D) medications for the prevention of organ complications. The aim of this study is to report baseline data and blinded interim analyses in the register-based randomised clinical trial (RRCT) SMARTEST, which compares metformin and the SGLT2 inhibitor dapagliflozin in early T2D. We also present learnings from the novel
BACKGROUND AND OBJECTIVE: Bacillus Calmette-Guérin (BCG) reduces disease recurrence and progression in intermediate- and high-risk non-muscle-invasive bladder cancer (NMIBC). BCG-associated adverse events during instillations are common, leading to treatment cessation. Prophylactic use of quinolones in conjunction with BCG instillations is one approach for reducing BCG-associated adverse events. O
IMPORTANCE Risk stratification strategies in primary prevention of coronary events lack precision. OBJECTIVE To determine whether prediction of first coronary events is improved by adding information on coronary atherosclerosis from coronary computed tomography angiography (CCTA) to a model using the pooled cohort equation (PCE) risk score tool and the coronary artery calcification score (CACS). D
Context. Ultra-hot Jupiters present a unique opportunity to understand the physics and chemistry of planets, their atmospheres, and interiors at extreme conditions. WASP-12 b stands out as an archetype of this class of exoplanets, with a close-in orbit around its star that results in intense stellar irradiation and tidal effects. Aims. The goals are to measure the planet's tidal deformation, atmos
Background: Previous literature indicate retinal hyperspectral imaging as a non-invasive method with the potential for identifying amyloid-beta (Aβ) protein deposits. Current diagnostic methods, such as cerebrospinal fluid analysis or positron emission tomography, are costly, invasive, and non-scalable. Hyperspectral imaging offers a potentially accessible alternative for early detection of Alzhei
Background: Emerging evidence indicates that estrogen receptor-low (ER-low)/human epidermal growth factor receptor 2 negative (HER2-) breast cancer (BC) may more closely resemble ER-negative (ER-zero, < 1%) rather than ER-positive disease in terms of biological and clinicopathological characteristics. In Sweden, ER-low (ER 1–9%) BC is managed as triple-negative breast cancer (TNBC) and is thus eli
Aim: This study evaluates the health effects of plant-based dairy alternatives in healthy individuals and those with Inflammatory Bowel Disease (IBD). Specifically, it investigates whether replacing one daily meal with a plant-based alternative has a positive impact on intestinal microbiota composition and gut health. It also investigates whether the effect of probiotic bacteria in yogurt depends
BACKGROUND: Medical students navigate a complex landscape of digital tools with potential to enhance learning. The main objectives of the current study were to investigate which digital resources are being used, which background factors are associated with utilization, perceived advantages and disadvantages of different digital resources, and explore future directions.METHODS: Cross-sectional, nat
PrologMikrovågs-hypertermi och strålbehandling (1980–1990)Min tidiga forskning inom medicinsk strålningsfysik ledde till kombinerad behandling av bröstcancer-recidiv med mikrovågsinducerad hypertermi och lågdos strålning (30 Gy). Kliniska försök inleddes med patienter som tidigare fått full stråldos (60 Gy). Utrustningen visades upp för kung Carl XVI Gustaf och drottning Silvia på Forskningens DagThis story has its origin in my presentation at the 1983 Research Day in Lund, to HM King XIV Gustav on our development of microwave-induced hyperthermia treatment of breast cancer recurrence, which brought me together with Professor Leif G. Salford, whose presentation was next to mine. Shortly before the turn of the millennium, Leif Salford initiated a clinical trial "Brain Immune Gene Tumour
Background: The response to the COVID-19 pandemic involved various lockdown measures, including school closures, which significantly impacted young populations, particularly in low-and middle-income countries (LMICs). Given the well-known protective effect of regular school attendance on sexual and reproductive health and rights (SRHR), reports of disrupted education, compromised SRHR, and an incr
By age 40 years, over 90% of adults with Down syndrome have Alzheimer's disease pathology and most progress to dementia. Despite having few systemic vascular risk factors, individuals with Down syndrome have elevated cerebrovascular disease markers that track with the clinical progression of Alzheimer's disease, suggesting a role of cerebrovascular disease that is hypothesized to be mediated by in
