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Inhaled corticosteroid (ICS) therapy is central to the long-term management of asthma and is extensively used in the management of chronic obstructive pulmonary disease (COPD). While administration via inhalation limits systemic exposure compared with oral or injected corticosteroids and, therefore, the risk of systemic corticosteroid-related adverse effects, concerns over the long-term safety of
BACKGROUND: Because hemodilution decreases the oxygen-carrying capacity of blood, it was hypothesized that severe hemodilution would decrease the tolerance to alveolar hypoxia. METHODS: Hemodynamics, oxygen transport, and blood lactate concentrations were compared in ten pigs with normal hematocrit (33 +/- 4%), and ten hemodiluted pigs (hematocrit 11 +/- 1%; mean +/- SD) anesthetized with ketamine
IMPORTANCE In age-related macular degeneration (AMD), rare variants in the complement system have been described, but their functional consequences remain largely unexplored. OBJECTIVES To identify new rare variants in complement genes and determine the functional effect of identified variants on complement levels and complement regulation in serum samples from carriers and noncarriers. DESIGN, SE
Popular Science SummaryPolymers are giant molecules consisting of a repetition of many small units (monomers) that are linked together by chemical bonds. If we consider a long necklace as a polymer chain, the beads are the monomers and the part of the thread which connects the beads together is the chemical bond. Polymers are important materials in our everyday life and they can be found e.g., in This thesis incorporates studies on the aqueous systems of two types of thermoresponsive amphiphilic block copolymers; a series of nonionic triblock copolymers comprising blocks of poly(ethylene oxide) (PEO) and poly(propylene oxide) (PPO) denoted as PEO-PPO-PEO block copolymers, and a series of ionic diblock copolymers consisting of one charged block and one block of poly(N-isopropylacrylamide) (
Ambient fine particulate matter PM2.5 (particles with a diameter smaller than 2.5 μm) has been associated with cardiovascular and respiratory morbidity and mortality. It has been shown that biomass burning for heat production purposes can generate large amounts of fine particles. Thus characteristics of particle emissions from biofuel combustion may be important in the assessment of health effects
BACKGROUND: Neurological disorders are increasingly recognised as major causes of death and disability worldwide. The aim of this analysis from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2016 is to provide the most comprehensive and up-to-date estimates of the global, regional, and national burden from neurological disorders.METHODS: We estimated prevalence, incidence, d
There is increasing evidence that short-chain fatty acids (SCFA) formed by colonic fermentation of indigestible carbohydrates have beneficial physiological effects. Butyric acid is the main energy substrate for the colonic mucosa and has been implicated as important in the prevention and treatment of diseases of the colonic mucosa, such as distal ulcerative colitis and cancer. Propionic acid, on t
Objective: To evaluate under- and overreporting and their determinants in the EPIC :24-hour diet recall (24-HDR) measurements collected in the European Prospective Investigation into Cancer and Nutrition (EPIC). Design: Cross-sectional analysis. 24-HDR measurements were obtained by means of a standardised computerised interview program (EPIC-SOFT). The ratio of reported energy intake (EI) to estim
The thesis concerns glycosyl transfer with use of b-glycosidases, most of them from hyperthermophilic organisms. Both optimisation of the reaction conditions and protein engineering in terms of site-directed mutagenesis were used to improve b-glycosidase-catalysed reactions. The first part of the work deals with conversion of lactose into valuable products such as galacto-oligosaccharides (GOS) an
Context. Parallaxes for 331 classical Cepheids, 31 Type II Cepheids, and 364 RR Lyrae stars in common between Gaia and the Hipparcos and Tycho-2 catalogues are published in Gaia Data Release 1 (DR1) as part of the Tycho-Gaia Astrometric Solution (TGAS). Aims. In order to test these first parallax measurements of the primary standard candles of the cosmological distance ladder, which involve astrom
Utbildningsplan för masterprogrammet i miljöstrategisk styrning/Master of Science in Environmental Management and Policy Programkod: XAMIS Omfattning: 120 högskolepoäng Tillträdesnivå: Avancerad nivå Beslutsfattare: Programledning W Utbildningsplanens giltighet: 2023/2022 Utbildningsplanen fastställd: 13 februari 2023 Undervisningsspråk: Engelska 2 1 SYFTE OCH MÅL 1.1 SYFTE Det internationella mas
https://www.iiiee.lu.se/sites/iiiee.lu.se/files/2023-02/EMP%20svensk%20programplan_2023_2024.pdf - 2026-07-09
Utbildningsplan för masterprogrammet i miljöstrategisk styrning/Master of Science in Environmental Management and Policy Programkod: XAMIS Omfattning: 120 högskolepoäng Tillträdesnivå: Avancerad nivå Beslutsfattare: Programledning W Utbildningsplanens giltighet: 2024/2025 Utbildningsplanen fastställd: 12 februari 2024 Undervisningsspråk: Engelska 2 1 SYFTE OCH MÅL 1.1 SYFTE Det internationella mas
https://www.iiiee.lu.se/sites/iiiee.lu.se/files/2024-03/EMP%20svensk%20programplan_2024_2025.pdf - 2026-07-09
Utbildningsplan för masterprogrammet i miljöstrategisk styrning/Master of Science in Environmental Management and Policy Programkod: XAMIS Omfattning: 120 HP Cykel: Andra Godkänd av: Godkänd av: programstyrelsen W Giltighet: 2025/2026 Datum för godkännande: 2025-02-10 Språk för undervisning: Engelska MÅL OCH RESULTAT 1.1 Syfte Det internationella masterprogrammet i miljöstrategisk styrning är utfo
Importance: Novel plasma biomarkers, especially phosphorylated tau (p-tau), can detect brain tau aggregates in Alzheimer disease. Objective: To determine which plasma biomarker combinations can accurately detect tau pathological brain changes in Down syndrome (DS). Design, Setting, and Participants: The cross-sectional, multicenter Alzheimer's Biomarker Consortium-Down Syndrome study included adul
On February 23, 2022, The EU Commission published its Proposal for a Directive of the European Parliament and of the Council on Corporate Sustainability Due Diligence and amending Directive (EU) 2019/1937 (“CSDDD” or “the Proposal”). The purpose of the Proposal, to further the “Union’s transition to a climate-neutral and green economy in line with the European Green Deal and in delivering on the U
Non-traditional stable isotope systems are increasingly used to study micronutrient cycling and acquisition in terrestrial ecosystems. We previously proposed for zinc (Zn) a conceptual model linking observed isotope signatures and fractionations to biogeochemical processes occurring in the rice soil environment and we suggested that 2’deoxymugineic acid (DMA) could play an important role for rice
BACKGROUND: Alzheimer's disease is characterized by an abnormal increase of phosphorylated tau (pTau) species in the CSF. It has been suggested that emergence of different pTau forms may parallel disease progression. Therefore, targeting multiple specific pTau forms may allow for a deeper understanding of disease evolution and underlying pathophysiology. Current immunoassays measure pTau epitopes
To cite this article: Cai G-H, Hashim JH, Hashim Z, Ali F, Bloom E, Larsson L, Lampa E, Norbäck D. Fungal DNA, allergens, mycotoxins and associations with asthmatic symptoms among pupils in schools from Johor Bahru, Malaysia. Pediatr Allergy Immunol 2011; 22: 290-297. ABSTRACT: While there is a large variation of prevalence of asthma symptoms worldwide, what we do know is that it is on the rise in
BACKGROUND: Mean diffusivity (MD) and fractional anisotropy (FA) from diffusion MRI (dMRI) have been associated with cell density and tissue anisotropy across tumors, but it is unknown whether these associations persist at the microscopic level.PURPOSE: To quantify the degree to which cell density and anisotropy, as determined from histology, account for the intra-tumor variability of MD and FA in
BACKGROUND. The reported prevalence of serious bacterial infections (SBI: urinary tract infection (UTI), bacteremia, and meningitis) among febrile infants ≤60 days of age varies from 8% to 23%. There are indications that the prevalence of infections differs between the sexes. Infants with fever at home but afebrile at the pediatric emergency department (PED) might have a lower risk of SBIs. Furthe
