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AIMS: The interleukin-1 receptor accessory protein (IL1RAP) is a co-receptor required for signalling through the IL-1, IL-33, and IL-36 receptors. Using a novel anti-IL1RAP-blocking antibody, we investigated the role of IL1RAP in atherosclerosis.METHODS AND RESULTS: Single-cell RNA sequencing data from human atherosclerotic plaques revealed the expression of IL1RAP and several IL1RAP-related cytok

An amplitude analysis of the B0→K∗0μ+μ- decay is presented. The analysis is based on data collected by the LHCb experiment from proton-proton collisions at s=7, 8 and 13 TeV, corresponding to an integrated luminosity of 4.7 fb-1. For the first time, Wilson coefficients and nonlocal hadronic contributions are accessed directly from the unbinned data, where the latter are parametrized as a function

An amplitude analysis of the B0→K∗0μ+μ- decay is presented using a dataset corresponding to an integrated luminosity of 4.7 fb-1 of pp collision data collected with the LHCb experiment. For the first time, the coefficients associated to short-distance physics effects, sensitive to processes beyond the standard model, are extracted directly from the data through a q2-unbinned amplitude analysis, wh

The concept of prefiguration has gained attention within environmental politics as a way to describe how everyday activism can enable transformation of unsustainable consumption practices, particularly around material necessities. Drawing on the case of Sweden’s flight-free movement, this article extends the research on prefigurative environmentalism to activism aimed at changing non-essential, ye

BACKGROUND: Elevated heart rate (HR) predicts cardiovascular disease and mortality, but there are no established normal limits for ambulatory HR. We used data from the Swedish CArdioPulmonary Imaging Study to determine reference ranges for ambulatory HR in a middle-aged population. We also studied clinical correlates of ambulatory HR.METHODS: A 24-hour ECG was registered in 5809 atrial fibrillatio

Abstract Purpose The purpose of the study was to analyse the surgical management and outcome regarding axial length in the population affected by pseudophakic retinal detachment (PRD) 2015?2020. Method The patients included were from an observational cohort study of patients undergoing cataract surgery in the region of Skåne during 2015?2017. Data were retrieved from the Swedish National Cataract Purpose The purpose of the study was to analyse the surgical management and outcome regarding axial length in the population affected by pseudophakic retinal detachment (PRD) 2015-2020. Method The patients included were from an observational cohort study of patients undergoing cataract surgery in the region of Skåne during 2015-2017. Data were retrieved from the Swedish National Cataract Register

We tested the chondrogenic potential of demineralized allogeneic bone matrix (DABM) in the repair of osteochondral defects. In 42 adult rabbits, a 5-mm2 or 15-mm2 defect was created bilaterally in the intercondylar groove of distal femur. DABM was inserted directly in 37 defects, whereas in 35 it was inserted after previous placement in muscle for 4, 16, or 19 days. Another 12 defects were left em

In developing heterotopic bone in the rat, induced by allogeneic bone matrix, we immunohistochemically detected nerves containing substance P (SP), calcitonin gene-related peptide (CGRP), neuropeptide Y (NPY), vasoactive intestinal polypeptide (VIP) and tyrosine hydroxylase (TH). After 10 days they were dicernible amidst differentiating chondroblastoid cells in fibrous tissue around and within the

The surface coating of biopores plays a pivotal role in mediating mass exchange between the biopore and the soil matrix, ultimately governing preferential flow in structured soils. However, quantitative experiments of the flow exchange dynamics in the soil around an earthworm burrow (drilosphere) are limited. Here, we developed an experimental setup to mimic preferential flow within a biopore whil

Field bio-remediation techniques (FBRT) can be a low cost method to avoid the removal of top layers of soil which are rich in organic matter and bio diversity. The use of native microorganisms in FBRT is preferable because non-indigenous species can transfer their genetic material to the environment with negative impacts on the local ecological equilibrium. Petroleum Produced Water (PPW) is an imp

Civic integration is an essential part of contemporary migration control regimes. This thesis examines what happens when civic integration policy enters domestic courts, by focusing on how Sweden’s migration courts (which are part of the administrative courts) apply the income and housing requirements for family reunification.The thesis revolves around a common discussion in the legal literature,

Phase field crystal (PFC) modeling has proved to be a versatile numerical tool in the analysis of crystalline microstructures. Most often, however, the focus is put on bulk crystal behavior, while crystal defects such as grain boundaries (GBs) are less explored. This is, in particular, the case for crystal structures beyond fcc and bcc. In this work, the possibilities and challenges in adopting PF