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Modulation of the sodium-chloride cotransporter by insulin in auditory cells : A potential link to diabetes-related hearing complications

Aim: While diabetes mellitus (types 1 and 2) is known to negatively impact vestibular and auditory function, the precise mechanisms underlying this effect are not fully understood. Building on our previous findings, which demonstrated the presence of insulin signaling components within the human saccule and identified the sodium transporter ENaC as a target for insulin signaling in HEI-OC1 auditor

The International Classification of Vestibular Disorders : Achievements, challenges, and future directions

In 2007, the Bárány Society embarked on a project to establish definitions of vestibular syndromes and disorders based on best available evidence, referred to as the International Classification of Vestibular Disorders (ICVD). Since then, numerous publications providing consensus-driven diagnostic criteria for vestibular symptoms, syndromes, and disorders have been published. Here, we reflect on t

A lung function threshold for survival? - FEV1Q and mortality in patients with COPD and chronic respiratory failure

INTRODUCTION: The FEV1 quotient (FEV1Q), calculated as the index between FEV1 and a theoretical lower survivable FEV1 threshold of 0.4L for females and 0.5L for males, has been investigated as a novel method of interpreting results from lung function testing. The applicability of the FEV1Q in populations with chronic respiratory failure has not been studied, and the continuous association between

Employee diversity and environmental innovation : the roles of gender, nationality, and education

This paper investigates the roles of employee diversity for environmental innovations in firms. Utilizing firm-level survey data on environmental innovations and employer–employee register data, we construct measures of employee diversity across education, nationality, and gender for over 6500 Swedish firms. We argue, grounded in the Lundvall–Johnson conceptualization of knowledge, that the positi

Evolutionary unpredictability in cancer model systems

Despite the advent of advanced molecular prognostic tools, it is still difficult to predict the course of disease for cancer patients at the individual level. This lack of predictability is also reflected in many experimental cancer model systems, begging the question of whether certain biological aspects of cancer (eg. growth, evolution etc.) can ever be anticipated or if there remains an inheren

Bladder cancer subtypes exhibit limited plasticity across different microenvironments and in metastases

BackgroundTranscriptomic and genomic analyses of bladder cancer (BC) reveal a highly diverse disease stratified into molecular subtypes with distinct molecular features and biological behaviors. Intratumor heterogeneity (ITH) and plasticity can significantly impact diagnosis and patient management, yet their extent in BC remains highly debated. Here, we investigated whether the three main bladder

Digital platforms for circular shopping: slowing down and speeding up second-hand clothing consumption

This paper aims to empirically explore and conceptualise how circular fashion platforms enable and shape the practice of secondhand clothes shopping. Taking a shopping-as-practice approach and drawing on an ethnographically inspired study, this paper explores how a Swedish digital second-hand commerce platform enables different modes of shopping. The analysis shows that this platform and its socio

Tilt-induced changes in f-wave characteristics during atrial fibrillation : an experimental and computational investigation

INTRODUCTION: This study explores transient and stationary effects of sympathetic and parasympathetic stimulation on f-wave characteristics in atrial fibrillation (AF) patients undergoing a tilt test. Transient phase is defined as the initial 2-minute interval following each postural change, reflecting immediate autonomic adaptation, whereas steady phase refers to the subsequent interval (from 3 m

Stakeholder Perspectives on Built Environmental Factors to Support Stroke Rehabilitation and Return to Everyday Life

BACKGROUND: The transition to undertaking rehabilitation in the home or local neighbourhood calls for an extensive understanding of which aspects of the built environment are important for people with stroke.OBJECTIVE: This qualitative study aims to explore how home and local neighbourhood environments support or hinder rehabilitation for people who have had a stroke from the perspectives of vario

Predictions, uncertainty, and collective epistemic work : How projected futures informed and misinformed enactments of Covid-19

By connecting an uncertain present to a potential future, predictions and other forms of projected futures construct meaningful contexts on which actors can lean when seeking to act in the face of uncertainty. This article outlines the background and careers of many, and often contradicting, futures that informed the collective work to define and represent Covid-19 in Sweden during the first half

Complement factors as biomarkers in ANCA-associated vasculitis in remission

Background Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a group of rare, autoimmune diseases causing inflammation in the vessel wall. Many organs can be affected, and kidney involvement is a common and serious manifestation. Complement activation is important in disease development and has also been detected in patients in remission. The reason for increased complemen

The plasma proteome reveals distinct signaling pathways associated with PR3-ANCA positive and MPO-ANCA positive vasculitis

OBJECTIVE: Despite recent advances, the pathophysiological mechanisms underlying anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV) remain incompletely understood, and comparative proteomic analyses of AAV subtypes are lacking. This study aimed to identify key molecular signaling pathways activated in AAV and to elucidate molecular distinctions between AAV with proteinase 3

Assessing symptom improvement in patients with postural orthostatic tachycardia syndrome (POTS) following a 16-week structured exercise programme : a protocol for a randomised cross-over trial in a clinical outpatient setting

INTRODUCTION: Exercise training is recommended as a complementary treatment in postural orthostatic tachycardia syndrome (POTS) according to international guidelines. However, less is known regarding how exercise training could successfully be implemented in clinical practice in patients with POTS. Thus, in the current study, we aim to assess the effect of a 16-week tailored exercise training prog

Rock Inscriptions above the Speos at Gebel el-Silsila

The present paper aims to serve as an initial publication focusing on a collection of rock inscriptions situated in the north-eastern cliff, positioned above and to the right of the façade of the renowned Speos at Gebel el-Silsila. Its purpose is to offer a preliminary glimpse into a comprehensive compilation of rock inscriptions from the area, presently being prepared for publication. Within this